Author(s): Asriullah Jabbar, Halik, Fadhliyah Malik, Muhammad Ilyas Y, Jamal Qadar, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi

Email(s): sylvia_pratiwi@ugm.ac.id

DOI: 10.52711/0974-360X.2024.00257   

Address: Asriullah Jabbar1,2,8, Halik2, Fadhliyah Malik2, Muhammad Ilyas Y2,3, Jamal Qadar4, Hasyrul Hamzah5,8, Sylvia Utami Tunjung Pratiwi6,7,8*
1Post Doctoral Program, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, Indonesia, 55281.
2Faculty of Pharmacy, Universitas Halu Oleo, Jl. H.E.A Mokodompit, Kendari, Indonesia, 93232.
3Politeknik Bina Husada Kendari, 93117, Indonesia.
4Puangrimaggalatung University, Sengkang, 90911, Indonesia.
5Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Kalimantan Timur 75124, Indonesia.
6Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281 Indonesia.
7Medical Plants and Natural Products Research Center Faculty of Pharmacy, Universitas Gadjah Mada Jl. Farmako Sekip Utara, Yogyakarta, Indonesia, 55281.
8Indonesia Biofilm Research Collaboration Center (IBRCC), Jl. Farmako Sekip Utara, Yogyakarta, Indonesia, 55281.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Etlingera rubroloba A.D Poulsen (E. rubroloba) plants from the genus Etlingera, empirically used as traditional medicine by several ethnicities in Southeast Sulawesi, namely to increase endurance and relieve joint pain. The purpose of this study was to determine the antihyperuricemia activity on uric acid levels and cyclooxygenase-2 (COX-2) levels in vivo in mice. This study used six groups of test animals consisting of normal, negative (Na-CMC) 0.5%, positive control (allopurinol) and dose groups of ethanol extract of E. rubroloba fruit 100, 200 and 300 mg/g bw. Modeling of hyperuricemia test animals is done by inducing potassium oxonate. Measurement of uric acid levels by lateral chromatography method and COX-2 levels by ELISA method. The results showed that ethanol extract of E. rubroloba fruit can reduce uric acid and COX-2 levels (p<0.05). The results of the correlation statistical test showed a positive correlation between uric acid levels and COX-2 levels, where the decrease in uric acid levels was directly proportional to the decrease in COX-2 levels. This research can be a reference in the development of traditional medicine, especially anti-hyperuricemia.


Cite this article:
Asriullah Jabbar, Halik, Fadhliyah Malik, Muhammad Ilyas Y, Jamal Qadar, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi. Antihyperurisemia Activity of Etanol Extract of Etlingera rubroloba A.D Poulsen Fruits on Uric Acid and Cyclooxygenase-2 Levels In Vivo. Research Journal of Pharmacy and Technology.2024; 17(4):1627-1. doi: 10.52711/0974-360X.2024.00257

Cite(Electronic):
Asriullah Jabbar, Halik, Fadhliyah Malik, Muhammad Ilyas Y, Jamal Qadar, Hasyrul Hamzah, Sylvia Utami Tunjung Pratiwi. Antihyperurisemia Activity of Etanol Extract of Etlingera rubroloba A.D Poulsen Fruits on Uric Acid and Cyclooxygenase-2 Levels In Vivo. Research Journal of Pharmacy and Technology.2024; 17(4):1627-1. doi: 10.52711/0974-360X.2024.00257   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-31


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