Author(s): Surajit Maity, Gopal Krishna Padhy, Lakshmi Kanta Kanthal, Suman pattanayak

Email(s): pharma.chemistry12@gmail.com

DOI: 10.52711/0974-360X.2024.00247   

Address: Surajit Maity1*, Gopal Krishna Padhy1, Lakshmi Kanta Kanthal2, Suman pattanayak2
1Centurion University and Technology and Management, Odisha, India.
2Haldia Institute of Pharmacy, Hatiberia, Haldia, West Bengal-721657, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Aims: The plant Gyrocarpus asiaticus Willd mainly found in south India comes under the family Hernandiaceae. Present phytochemical analysis by GC-MS is to identify compounds and their structural determination and examine antioxidant properties of the plant. Methodology: GC-MS analysis of a hydroalcoholic extract of Gyrocarpus asiaticus Willd was done on Shimadzu QP 2010 Ultra, and carrier gas was used as Helium and Nitrogen. In-vitro antioxidant activity of hydroalcoholic extract carried out by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method, Ascorbic acid used as a standard drug and analyzed by UV-Visible spectrophotometer (Analytical 2008). Result: The GC-MS analysis of the hydroalcoholic extract shows there are several phytochemical constituents present. From the library of the GC-MS, there are a total of 105 compounds are identified like Alpha -toluenephosphoric acid, 1,2-Benzenedicarboxylic acid, diethyl ester, n-Tetradecanoic acid, Eicosen-1-ol, N -Tridecoic acid, Phytyl eicosanoate, Pentadecane carboxylic acid, Heptadecanoic acid, 9-Octadecenoic acid, Octadecanoic acid, Doxepin, Rotenone, Vitamin D3, Vitamin D2, Beta carotene, Calcifediol, Vitamin E, Amoxapine, Cholesteone. The in-vitro antioxidant study of 20,40,60,80,100 µg/ml concentration of the hydroalcoholic extract of the plant shows % of free radical scavenging activity like 46.07, 56.27, 68.35, 73.89, and 73.55 and shows IC50 value 44.63. Conclusion: The hydroalcoholic extract of Gyrocarpus asiaticus WILLD shows various biologically active compounds and significant antioxidant activity.


Cite this article:
Surajit Maity, Gopal Krishna Padhy, Lakshmi Kanta Kanthal, Suman pattanayak. GC-MS analysis and antioxidant activity of Gyrocarpus asiaticus Willd. Research Journal of Pharmacy and Technology.2024; 17(4):1565-0 doi: 10.52711/0974-360X.2024.00247

Cite(Electronic):
Surajit Maity, Gopal Krishna Padhy, Lakshmi Kanta Kanthal, Suman pattanayak. GC-MS analysis and antioxidant activity of Gyrocarpus asiaticus Willd. Research Journal of Pharmacy and Technology.2024; 17(4):1565-0 doi: 10.52711/0974-360X.2024.00247   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-21


REFERENCES:
1.    Keawsaard S. Kongtaweelert S. Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves. Chiang Mai J. Sci. 2012;39(3):455-63.
2.    Kanthal LK, Sreekanth N, Madhuri PL, Bhar K and Mandal P. Antibacterial Potential of Aqueous Extract of Gyrocarpus asiaticus WILLD. International Journal of Pharmaceutical Letters and Reviews. 2015; 1(1): 1-3.
3.    Kanthal LK. Dey A. Satyavathi K. Bhojaraju P. GC-MS Analysis of Methanolic Extract of Gyrocarpus asiaticus Willd. Asian Journal of Chemistry 2015; 27(2):511-3.
4.    Kanthal LK. Dey A. Satyavathi K. Bhojaraju P. Antibacterial potential of methanolic extract of Gyrocarpus asiaticus Willd. Asian Journal of Clinical Research 2014; 7(1):192-4.
5.    Kanthal LK. Dey A. Satyavathi K. Bhojaraju P. Evaluation of antihelmintic activity of Gyrocarpus asiaticus Willd and Lactuca runcinata DC on the Pheritima posthuma model. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5: 273-5.
6.    Yelchuri P. Yajaman S. Assessment of antidiabetic activity of ethanolic extracts of Gyrocarpus asiaticus Willd bark against Streptozotocin induced diabetes in rats. International Journal of Advances in Pharmacy Biology and Chemistry 2014; 3(1):6-71.
7.    Kavitha S ,  Kannan MVR , Mani P, Identification of Bioactive Compounds in the leaves extract of Piper longum using GCMS, Research Journal of Pharmacy and Technology,  2020; 13(7): 3169-3170. Doi.org/ 10.5958/0974-360X.2020.00560.0.
8.    Devi JAI. Muthu AK. Hypolipidemic effect of ethanolic extract from whole plant of Lactuca runcinata (DC.) in atherogenic diet induced hyperlipidemic rats. African Journal of Pharmacy and Pharmacology 2015; 9(47): 1080-7.
9.    Akbari A, Nasiri K, Heydari M, Mosavat SH, Iraji A. The Protective Effect of Hydroalcoholic Extract of Zingiber Officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats. Journal of Evidence-Based complementary & Alternative Medicine. 2017; 22(4):609-617.
10.    Pandey A, Tripathi S. Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. Journal of Pharmacognosy and Phytochemistry. 2014; 2(5):115-119.
11.    Saraswathi  K , Sivaraj C, Jenifer A , Dhivya M , Arumugam P. Antioxidant, Antibacterial activities, GCMS and FTIR Analysis of Ethanol bark extract of Capparis sepiaria L. Research Journal of Pharmacy and Technology,  2020; 13(5): 2144-2150. Doi.org/ 10.5958/0974-360X.2020.00385.6.
12.    Kanthal LK, Sreekanth N,Madhuri PL, Bhar K and Mandal P. Antibacterial Potential of Aqueous Extract of Gyrocarpus asiaticus Willd. International Journal of Pharmaceutical Letters and Reviews. 2015; 1(1): 1-3.
13.    MahejabeenS and Nirmala P. GC-MS Analysis of Isolated Ethyl Acetate Extract of Citrus Sinuses Peel. International Journal of Innovative Research and Advanced Studies 2018; 5(4):45-48.
14.    Mathi P, Nikhil K, Das S, Roy P, Bokka VR, Botlagunta M. Evaluation of In vitro Anticancer Activity and GC-MS analysis from leaf Sophora interruptaBeed. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7(5):303-308.
15.    Pandian RS, Noora AT, GC-MS Analysis of Phytochemical Compounds Present in the Leaves of Citrus medica. L, Research Journal of Pharmacy and Technology. 2019; 12(4):1823-1826. Doi.org/10.5958/0974-360X.2019.00304.4.
16.    Asgarpanah J, Motamed SM, Farzaneh A, Ghanizadesh B, Tomraee S. Antioxidant activity and total phenolic and flavonoid content of Astragalussquarrosus Bunge. African Journal of Biotechnology. 2011; 10(82):19176-19180.
17.    Patan A, Saranya M, Vignesh S, Bharathi A, Vikram G, Yuvaraj P, Vijeyaanandhi M, Qualitative Phytochemical Analysis in Determination of Antioxidant Activity of Methanolic Extract of Oenothera biennis by GCMS – A Preliminary Research Study, Research Journal of Pharmacy and Technology, 2021; 14(7):3744-3750. Doi.org/10.52711/0974-360X.2021.00648.
18.    Marref SE, Benkiki  N, Melakhessou MA, In vitro antioxidant activity, Total phenolic and Flavonoids Contents of Gladiolus segetum Extracts. Research Journal pf pharmacy and Technology.2018: 11(11): 5017-5023.Doi.org/360X.2018.00915.0.
19.    Manikandan R, Anand V. A Review on Antioxidant activity of Psidium guajava. Research Journal pf pharmacy and Technology. 2015: 8(3): 339-342.Doi.org/0974-360X.2015.00056.6.
20.    Aya Alabdali A, Kzar M, Chinnappan S, Mogana R, Khalivull SI, Rahman H, Basma M.  Razi ABD. Antioxidant activity of Curcumin, Research Journal of Pharmacy and Technology. 2021; 14(12):6741-6. Doi.org/ 10.52711/0974-360X.2021.01164.
21.    Despande R, Chandrasekhar KS, Vasudev RP, Venkatesh K, Aswatha RHN. In vitro Antioxidant potential and Anti-Bacterial Activities of of Rajanyadi Chuma Extracts Against Eschechia coli. Research Journal pf pharmacy and Technology. 2022: 15(11): 5120-5125.Doi.org/10.52711/0974-360X.2022.00861.
22.    Gangadhara MM, Dinesha R, Satish ,Murari SK. A non-cytotoxic pseudo peptide KL1 with potent antioxidant activity. Asian Journal of Research in Chemistry. 2017; 10(2):127-130. Doi.org/ 10.5958/0974-4150.2017.00020.7.
23.    Amina BB, Roukia H, Amahammed H Mahfoud, TA, Sabrina B, Chahrazed B, Houria B. Optimization of Extraction conditions of the Polyphenols, Flavonoids and the Antioxidant activity of the plant Ammosperma cinereum (Brassicaceae) through the Response Surface Methodology (RSM). Asian Journal of Research in Chemistry. 2020; 13(1):01-06.Doi.org/ 10.5958/0974-4150.2020.00001.2.

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