Author(s): Tinni Trihartini Maskoen, Riska W Kuntari, Muhammad Andy Prihartono, Hardisiswo Soedjana, Ani Melani Maskoen, Basri A. Gani


DOI: 10.52711/0974-360X.2024.00228   

Address: Tinni Trihartini Maskoen1*, Riska W Kuntari1, Muhammad Andy Prihartono1, Hardisiswo Soedjana2, Ani Melani Maskoen3, Basri A. Gani4
1Department of Anaesthesiology and Intensive Therapy, Medical Faculty, Universitas Padjajaran, Bandung, Jawa Barat, Indonesia.
2Department of Plastic Surgery, Medical Faculty, Universitas Padjajaran, Bandung, Jawa Barat, Indonesia.
3Department of Oral Biology, Denstristry Faculty, Universitas Padjajaran, Bandung, Jawa Barat, Indonesia.
4Department of Oral Biology, Denstristry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indoenesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024

Labioplasty discomfort can be prevented by inhibiting the infraorbital nerve. Ketamine can be utilized as an adjuvant to lengthen the duration of analgesia in the infraorbital block when bupivacaine is used for infraorbital blocks within a relatively short period. This study aimed to assess the analgesic duration of bupivacaine and bupivacaine-ketamine on the infraorbital block in patients undergoing labioplasty, using the FLACC pain score.The research is a prospective approach, randomized, controlled clinical experiment with double-blinding. Thirty subjects, 3-12month-old children with ASA I and II status, received labioplasty surgery. Subjects were administered 1mL of each infraorbital block with 0.25% Bupivacaine and 0.25% Bupivacaine with Ketamine 0.5mg/kg BW to each group. The Paired T-test was used to compare subject characteristics, while the Independent T-test was used to compare heart rate. Chi-square (Fisher's exact) analysis revealed a significance level of p 0.005 for the FLACC value comparison. All statistical test results were examined with SPSS version 25.0. In the Bupivacaine group, there was an increase in mild pain within 4-5hours (7:46.7%); by 6 hours, there was an increase in mild pain in all 15 participants. At eight hours, it progressed to moderate pain (7:46.7%) with 496 minutes of analgesia and light pain (8:53.7%). The individuals in the Bupivacaine-Ketamine group had pain between 5-8 hours. Six patients (40%) with a pain-free analgesia duration of 1.440 minutes and nine (60%) with a minor pain status had FLACC values 4 during 24-hour observations.Bupivacaine and Bupivacaine-Ketamine have no side effects and no change in heart rate. Combining Bupivacaine with Ketamine has a more prolonged postoperative analgesic effect (24 hours) than the bupivacaine group in the infraorbital block in labioplasty patients (8 hours).

Cite this article:
Tinni Trihartini Maskoen, Riska W Kuntari, Muhammad Andy Prihartono, Hardisiswo Soedjana, Ani Melani Maskoen, Basri A. Gani. Effect of Infraorbital Block by Bupivacaine and Bupivacaine-Ketamine against Analgesics duration in Labioplasty patients. Research Journal of Pharmacy and Technology.2024; 17(4):1441-8. doi: 10.52711/0974-360X.2024.00228

Tinni Trihartini Maskoen, Riska W Kuntari, Muhammad Andy Prihartono, Hardisiswo Soedjana, Ani Melani Maskoen, Basri A. Gani. Effect of Infraorbital Block by Bupivacaine and Bupivacaine-Ketamine against Analgesics duration in Labioplasty patients. Research Journal of Pharmacy and Technology.2024; 17(4):1441-8. doi: 10.52711/0974-360X.2024.00228   Available on:

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