Author(s): Lin Mosbah Katramiz, Doaa Kamal Alkhlaidi, Muneeb Ahsan, Dujana Mostafa Hamed

Email(s): dr.doaakamal@dpc.edu

DOI: 10.52711/0974-360X.2024.00245   

Address: Lin Mosbah Katramiz1, Doaa Kamal Alkhlaidi1*, Muneeb Ahsan2, Dujana Mostafa Hamed3
1Dubai Pharmacy College for Girls, Pharmacy Practice Department, Dubai, United Arab Emirates.
2Rashid Hospital, Dubai, United Arab Emirates.
3Rashid Hospital, Infectious Disease Department, Dubai, United Arab Emirates.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Purpose: COVID-19 outbreak has created a public health crisis starting from December 2019. Vitamin D has raised as a protective factor that can take part in reducing risk of infection. It has an immunomodulatory wide spectrum action. This study aims to ascertain the physicians’ perceptions regarding Vitamin D role as adjuvant therapy in COVID-19 infection. Methods: A descriptive qualitative design was approached. Data collection took place in a governmental tertiary hospital in Dubai, United Arab Emirates. A semi-structured interview guide was developed and validated for this purpose. In-depth individual interviews with physicians (n=20) from different departments were conducted. The participants were enrolled until reaching the saturation level. The interviews were recorded and transcribed. A thematic content analysis was performed. Results: After analysis, three elemental themes with subthemes emerged that described physicians’ experience and perceptions: general protocol followed for prescribing Vitamin D in COVID-19 patients, Clinical effect of Vitamin D in COVID-19 disease, Vitamin D deficiency and COVID-19 mortality. Different responses were obtained from physicians reflecting their experience with COVID-19 patients. Conclusion: The findings revealed physicians’ experience of Vitamin D clinical effect in COVID-19. Physicians stated the different regimen of Vitamin D used in COVID-19 patients and declared the association of Vitamin D in different COVID-19 cases but, no relation of Vitamin D deficiency and COVID-19 mortality as per physicians’ experience.


Cite this article:
Lin Mosbah Katramiz, Doaa Kamal Alkhlaidi, Muneeb Ahsan, Dujana Mostafa Hamed. Physicians’ Perceptions regarding the Role of Vitamin D in COVID-19 Management: A Qualitative Study. Research Journal of Pharmacy and Technology.2024; 17(4):1551-8. doi: 10.52711/0974-360X.2024.00245

Cite(Electronic):
Lin Mosbah Katramiz, Doaa Kamal Alkhlaidi, Muneeb Ahsan, Dujana Mostafa Hamed. Physicians’ Perceptions regarding the Role of Vitamin D in COVID-19 Management: A Qualitative Study. Research Journal of Pharmacy and Technology.2024; 17(4):1551-8. doi: 10.52711/0974-360X.2024.00245   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-19


REFERENCES:
1.    Ritika Gupta. The Management of Coronavius Pandemic 2019-2020. Asian J. Pharm. Res. 2020; 10(4):327-330.
2.    Vaishnavi. K. Patil, Azam. Z. Shaikh. Corona (Covid - 19). Asian J. Pharm. Res. 2020; 10(4): 275-285.
3.    Subhashis Debnath, Runa Chakravorty, Donita Devi. COVID 19 and its management. Asian Journal of Pharmaceutical Research. 2021; 11(2): 117-1.
4.    Subhashis Debnath, Jaya Saha. Coronavirus disease (COVID-19): A global threat. Asian Journal of Pharmacy and Technology. 2022; 12(1): 63-9.
5.    Archana B. Chavhan, Pavan S. Jadhav, Satish Shelke. COVID 19: Outbreak, Structure and Current therapeutic strategies. Asian J. Pharm. Tech. 2021; 11(1): 76-83.
6.    Kandra Naga Vishnu, Praveen Kumar Uppala, Yakaiah Vangoori, Siva Naga Koteswara Rao Gudhanti. A Review on Covid 19 Pandemic and its Global Effects. Asian Journal of Pharmaceutical Research. 2021; 11(4): 242-6.
7.    Bassatne, A., Basbous, M., Chakhtoura, M., El Zein, O., Rahme, M., and El-Hajj Fuleihan, G. (2021). The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis. Metabolism: Clinical and Experimental, 119, 154753. https://doi.org/10.1016/j.metabol.2021.154753
8.    Shakoor, H., Feehan, J., Al Dhaheri, A. S., Ali, H. I., Platat, C., Ismail, L. C., Apostolopoulos, V., and Stojanovska, L. (2021). Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas, 143(June 2020), 1–9. https://doi.org/10.1016/j.maturitas.2020.08.003
9.    Hopkins J. COVID-19 Map - Johns Hopkins Coronavirus Resource Center. Johns Hopkins Coronavirus Resource Center. Published 2020. https://coronavirus.jhu.edu/map.html. Accessed September 22, 2021.
10.    Alexander, J., Tinkov, A., Strand, T. A., Alehagen, U., Skalny, A., Aaseth, J., and No, J. A. (n.d.). Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. https://doi.org/10.3390/nu12082358
11.    Hacışevki, A., and Baba, B. The Impact of ACE2 Gene Polymorphism in the Development of COVID-19 Disease. In Gazi Medical Journal. 2020; 31(3A): 523–527. https://doi.org/10.12996/gmj.2020.122
12.    COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. Disponible en: https://covid19treatmentguidelines.nih.gov/. Natl Inst Heal. 2020;2019:130. https://www.covid19treatmentguidelines.nih.gov/
13.    Ebadi M, Montano-Loza AJ. Perspective: improving Vitamin D status in the management of COVID-19. Eur J Clin Nutr. 2020; 74: 856-859.
14.    Arboleda JF, Urcuqui-Inchima S. Vitamin D Supplementation: A Potential Approach for Coronavirus/COVID-19 Therapeutics? Front Immunol. 2020; 11:1523.
15.    AlSafar, H., Grant, W. B., Hijazi, R., Uddin, M., Alkaabi, N., Tay, G., Mahboub, B., and Al Anouti, F. COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents. Nutrients. 2021; 13(5): 1714. https://doi.org/10.3390/nu13051714
16.    Benskin LL. A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency. Front Public Heal. 2020;8.
17.    Searby A, Burr D. The impact of COVID-19 on alcohol and other drug nurses’ provision of care: A qualitative descriptive study. J Clin Nurs. 2021; 30(11-12): 1730-1741.
18.    Roberts, D. M., Sevastos, J., Carland, J. E., Stocker, S. L., and Lea-Henry, T. N. (2018). Clinical Pharmacokinetics in Kidney Disease: Application to Rational Design of Dosing Regimens. Clinical Journal of the American Society of Nephrology : CJASN, 13(8): 1254. https://doi.org/10.2215/CJN.05150418
19.    D’avolio, A., Avataneo, V., Manca, A., Cusato, J., De Nicolò, A., Lucchini, R., Keller, F., and Cantù, M.  25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020; 12(5): 1359. https://doi.org/10.3390/nu12051359
20.    Hindustan Abdul Ahad, Haranath Chinthaginjala, Bhavani Haribabu Sai Dharani, Momin Umaira Ayisha, Chukkaluri Anu Reddy, Gandhodi Chandra Manasa, Nandini Nandini. Country Wise Measures in Contrast to The Spread of SARS-COV2/COVID-19. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1): 62-4.
21.    Dhanashri Aware, Sachin Rohane. A Role of Herbal Drug as an Immunity Booster during Covid-19 Pandemic. Asian Journal of Pharmaceutical Research. 2021; 11(3): 206-1.
22.    Ashwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. PatelAshwini P. Dhruv, Nilesh K. Patel, Ashok B. Patel, Amit Kumar J. Vyas, Ajay I. Patel. A Review on Prophylactic Regimen by Evaluation of Asymptomatic SARS CoV-II Carriers. Asian Journal of Pharmaceutical Research. 2022; 12(3): 217-4.
23.    Ajay I. Patel, Pooja R. Maru, Ashok B. Patel, Amitkumar J. Vyas, Nilesh K. Patel. Role of Vitamins, Minerals and Herbs in Strengthening immune system against the newly Emerging Viral Disease SARS-CoV-2. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(4): 309-5.
24.    Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutr.  2020; 12(1): 236.
25.    Rossetti, M., Martucci, G., Starchl, C., and Amrein, K. Micronutrients in Sepsis and COVID-19: A Narrative Review on What We Have Learned and What We Want to Know in Future Trials. Medicina. 2021; 57(5): 419. https://doi.org/10.3390/MEDICINA57050419
26.    Gröber U, Holick MF. The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients. https://doi.org/101024/0300-9831/a000693. Published online January 25, 2021.
27.    Sunil J. Wimalawansa, MD, PhD, MBA, FACP, FRCP, FRCPath DsP. Global Epidemic of Coronavirus—Covid-19: What Can We Do To Minimize Risks. Eur J Biomed Pharm Sci. 2020; 7(3): 432-438.
28.    Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., Dubnov-Raz, G., Esposito, S., Ganmaa, D., et al. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ (Online). 2017: 356. https://doi.org/10.1136/bmj.i6583.
29.    Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R., and Quesada Gomez, J. M.. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. Journal of Steroid Biochemistry and Molecular Biology. 2020; 203. https://doi.org/10.1016/j.jsbmb.2020.105751
30.    Gois, P. H. F., Ferreira, D., Olenski, S., and Seguro, A. C. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients, 2017; 9(7). https://doi.org/10.3390/NU9070651
31.    Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013; 5(1): 51.
32.    Charoenngam, N., Shirvani, A., Reddy, N., Vodopivec, D. M., Apovian, C. M., and Holick, M. F. Association of Vitamin D Status With Hospital Morbidity and Mortality in Adult Hospitalized Patients With COVID-19. Endocrine Practice. 2021; 27(4): 271–278. https://doi.org/10.1016/J.EPRAC.2021.02.013
33.    Brenner, H., Schöttker, B., Mohan, M., Cherian, J. J., Sharma, A., Yisak, H., Ewunetei, A., Kefale, B., Mamuye, M., Teshome, F., et al. Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of Infection and Public Health. 2020; 14: 1373–1380. https://doi.org/10.1016/j.jiph.2020.06.021
34.    Li Y, Li Q, Zhang N, Liu Z. Sunlight and vitamin D in the prevention of coronavirus disease (COVID-19) infection and mortality in the United States (preprint, in review); 2020. doi:10.21203/rs.3.rs-32499/v1
35.    Fasano, A., Cereda, E., Barichella, M., Cassani, E., Ferri, V., Zecchinelli, A. L., and Pezzoli, G. COVID-19 in Parkinson’s Disease Patients Living in Lombardy, Italy. Movement Disorders. 2020; 35(7): 1089–1093. https://doi.org/10.1002/mds.28176
36.    D’avolio, A., Avataneo, V., Manca, A., Cusato, J., De Nicolò, A., Lucchini, R., Keller, F., and Cantù, M. 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020; 12(5): 1359. https://doi.org/10.3390/nu12051359
37.    Meltzer, D. O., Best, T. J., Zhang, H., Vokes, T., Arora, V., and Solway, J. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results Key Points + Supplemental content. JAMA Network Open. 2020; 3(9): 2019722. https://doi.org/10.1001/jamanetworkopen.2020.19722.
38.    Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. 2020;(January).
39.    Braiman MS. Latitude dependence of the COVID-19 mortality rate-a possible relationship to vitamin D deficiency? https://ssrn.com/abstract=3561958 Accessed July 21, 2021.
40.    Anouti, F. Al, Thomas, J., Abdel-Wareth, L., Rajah, J., Grant, W. B., and Haq, A. Vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates. Dermato-Endocrinology. 2011; 3(4): 235. https://doi.org/10.4161/DERM.3.4.16881
41.    Haq, A., Svobodová, J., Imran, S., Stanford, C., and Razzaque, M. S. Vitamin D deficiency: A single centre analysis of patients from 136 countries. Journal of Steroid Biochemistry and Molecular Biology. 2016; 164: 209–213. https://doi.org/10.1016/j.jsbmb.2016.02.007.
42.    Alguwaihes, A. M., Sabico, S., Hasanato, R., Al-Sofiani, M. E., Megdad, M., Albader, S. S., Alsari, M. H., Alelayan, A., Alyusuf, E. Y., Alzahrani, S. H., et al. Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective case–control study in an Arab Gulf country. Aging Clinical and Experimental Research. 2021; 33(5): 1. https://doi.org/10.1007/S40520-021-01831-0
43.    Kazemi, A., Mohammadi, V., Aghababaee, S. K., Golzarand, M., Clark, C. C. T., and Babajafari, S. Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis. Advances in Nutrition. 2021. https://doi.org/10.1093/ADVANCES/NMAB012.
44.    Abdollahi, A., Kamali Sarvestani, H., Rafat, Z., Ghaderkhani, S., Mahmoudi-Aliabadi, M., Jafarzadeh, B., and Mehrtash, V. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID-19 infection: A case–control study of hospitalized patients in Tehran, Iran. Journal of Medical Virology. 2021; 93(4): 2359–2364. https://doi.org/10.1002/jmv.26726
45.    Radujkovic, A., Hippchen, T., Tiwari-Heckler, S., Dreher, S., Boxberger, M., and Merle, U. Vitamin D Deficiency and Outcome of COVID-19 Patients. 2020. https://doi.org/10.3390/nu12092757.
46.    Karahan S, Katkat F. Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey. J Nutr Heal Aging. 2021; 25(2): 189-196.
47.    Hernández, J. L., Nan, D., Fernandez-Ayala, M., Garciá-Unzueta, M., Hernández-Hernández, M. A., López-Hoyos, M., Muñoz-Cacho, P., Olmos, J. M., Gutiérrez-Cuadra, M., et al. Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. Journal of Clinical Endocrinology and Metabolism. 2021; 106(3): E1343–E1353. https://doi.org/10.1210/clinem/dgaa733.
48.    CW Y. COVID-19 and African Americans. JAMA. 2020; 323(19): 1891-1892.
49.    BR, Y., A, W., R, F., M, F., A, O., C, et al. Association of Race With Mortality Among Patients Hospitalized With Coronavirus Disease 2019 (COVID-19) at 92 US Hospitals. JAMA Network Open. 2020; 3(8). https://doi.org/10.1001/JAMANETWORKOPEN.2020.18039
50.    Kenneth Weir, E., Thenappan, A. T., Bhargava, M., Chen, Y., Thenappan, T., Bhargava, M., Chen, Y., Thenappan, A. T., Bhargava, M., and Chen, Y. Does vitamin D deficiency increase the severity of COVID-19? Clinical Medicine. 2020; 20(4): 107–115. https://doi.org/10.7861/clinmed.2020-0301
51.    Cook TM. Personal protective equipment during the coronavirus disease (COVID) 2019 pandemic – a narrative review. Anaesthesia. 2020; 75(7): 920-927.
52.    Jain SK, Parsanathan R. Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? J Am Coll Nutr. Published online. 2020: 694-699.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available