Author(s): Pradeep Kumar Samal, Namrata Kurre, Bharti Ahirwar, Kedar Prasad Meena, Bharti Vaishnaw, Aarti Tiwari, Kamdev Sen, Dipendra Nirmalkar, Pameshwar Sahu, Geetanjali Darsena

Email(s): samalpharmacology@rediffmail.com

DOI: 10.52711/0974-360X.2024.00241   

Address: Pradeep Kumar Samal*, Namrata Kurre*, Bharti Ahirwar, Kedar Prasad Meena, Bharti Vaishnaw, Aarti Tiwari, Kamdev Sen, Dipendra Nirmalkar, Pameshwar Sahu, Geetanjali Darsena Pharmacy Department, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2024


ABSTRACT:
Introduction: Apigenin is a flavonoid found in many fruits and vegetables as well as in Chinese medicinal herbs. This study aimed to assess the anti-inflammatory and analgesic effects of Apigenin. Materials and Methods: Carrageenan-induced mouse paw edema was used to assess anti-inflammatory activityand Eddy's hot plate analgesiometer was used to assess analgesic activity. Results and Discussion: Apigenin at dosages of 25 mg/kg and 50mg/kg body weight significantly reduced Carrageenan-induced paw edema by 41.21% (3–9 h) and 61.4% (3–9 h), respectively. Apigenin 25mg/kg and 50mg/kg body weight produced significant dose-response analgesic activity in the hot plate test. Conclusion: The findings in this study suggest that Apigenin possesses anti-inflammatory and analgesic activities in a dose dependent manner.


Cite this article:
Pradeep Kumar Samal, Namrata Kurre, Bharti Ahirwar, Kedar Prasad Meena, Bharti Vaishnaw, Aarti Tiwari, Kamdev Sen, Dipendra Nirmalkar, Pameshwar Sahu, Geetanjali Darsena. Pharmacological screening of Anti-inflammatory and Analgesic activity of Apigenin in Mice Model. Research Journal of Pharmacy and Technology.2024; 17(4):1527-0. doi: 10.52711/0974-360X.2024.00241

Cite(Electronic):
Pradeep Kumar Samal, Namrata Kurre, Bharti Ahirwar, Kedar Prasad Meena, Bharti Vaishnaw, Aarti Tiwari, Kamdev Sen, Dipendra Nirmalkar, Pameshwar Sahu, Geetanjali Darsena. Pharmacological screening of Anti-inflammatory and Analgesic activity of Apigenin in Mice Model. Research Journal of Pharmacy and Technology.2024; 17(4):1527-0. doi: 10.52711/0974-360X.2024.00241   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-4-15


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