Author(s): Satutya Wicaksono, Jola Rahmahani, Diah Savitri Ernawati, Fedik Abdul Rantam, Theresia Indah Budhy, Alexander Patera Nugraha, Reyhan Mahendra Nur, Nuraini Indrastie, Nastiti Faradilla Ramadhani, Tengku Natasha Eleenabinti Tengku Ahmad Noor

Email(s): alexander.patera.nugraha@fkg.unair.ac.id

DOI: 10.52711/0974-360X.2024.00223   

Address: Satutya Wicaksono1, Jola Rahmahani2, Diah Savitri Ernawati3, Fedik Abdul Rantam3, Theresia Indah Budhy4,5, Alexander Patera Nugraha6,7, Reyhan Mahendra Nur6, Nuraini Indrastie, Nastiti Faradilla Ramadhani7,8, Tengku Natasha Eleenabinti Tengku Ahmad Noor9,10
1Graduate Student of Immunology, Postgraduate School, Universitas Airlangga, Surabaya, Indonesia.
2Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
3Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
4Immunology Study Program, Postgraduate School, Universitas Airlangga, Surabaya, Indonesia.
5Department of Oral and Maxillofacial Pathology, Universitas Airlangga, Surabaya, Indonesia.
6Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
7Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
8Departm

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
Introduction: Paracrine effects exerted by trophic factors secreted by the mesenchymal stem cell (MSCs) are now considered the primary mechanism of regenerative abilities. These trophic factors, comprised of various growth factors, cytokines, microvesicles, and exosomes, are collectively called MSC secretome (MSC-S). MCS-S is thought to be a promising means of regenerative therapy. Architectural and functional oral epithelial loss in oral ulcerative lesions (OUL) may become the proper target for MSC-S regenerative therapy. Several pre-clinical studies have been conducted to assess the potential of MSC-S to facilitate OUL healing. Aim: Thus, this article attempts to review current relevant studies regarding the applicability of MSC-S for OUL management. Method: This review was based on a literature search on several sites (PubMed, Scopus, ScienceDirect) with specific keywords "MSC secretome", “regenerative therapy”, "oral ulcer", and "regenerative therapy", "wound healing". Results: A total of 37 articles were included in this review. Conclusion: Based on the results, we concluded that MSC-S could improve oral mucosa regeneration and repair. Thus MSC-S would be a promising therapy for OUL therapy.


Cite this article:
Satutya Wicaksono, Jola Rahmahani, Diah Savitri Ernawati, Fedik Abdul Rantam, Theresia Indah Budhy, Alexander Patera Nugraha, Reyhan Mahendra Nur, Nuraini Indrastie, Nastiti Faradilla Ramadhani, Tengku Natasha Eleenabinti Tengku Ahmad Noor. Mesenchymal Stem Cell Secretome as Novel Regenerative Approach in Oral Ulcerative Lesions Management: A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1408-3. doi: 10.52711/0974-360X.2024.00223

Cite(Electronic):
Satutya Wicaksono, Jola Rahmahani, Diah Savitri Ernawati, Fedik Abdul Rantam, Theresia Indah Budhy, Alexander Patera Nugraha, Reyhan Mahendra Nur, Nuraini Indrastie, Nastiti Faradilla Ramadhani, Tengku Natasha Eleenabinti Tengku Ahmad Noor. Mesenchymal Stem Cell Secretome as Novel Regenerative Approach in Oral Ulcerative Lesions Management: A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1408-3. doi: 10.52711/0974-360X.2024.00223   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-3-74


REFERENCES:
1.    Farah CS, Balasubramaniam R, McCullough MJ, editors. Contemporary oral medicine: A comprehensive approach to clinical practice. Springer International Publishing; 2019.
2.    Gottrup F, Apelqvist J, Bjarnsholt T, Cooper R, Moore Z, Peters EJ, Probst S. Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions—key messages. J Wound Care. 2014; 23(10): 477-482. https://doi.org/10.12968/jowc.2014.23.10.477.
3.    Karavana SY, Sezer B, Güneri P, Veral A, Boyacioğlu H, Ertan G, Epstein JB. Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. Inter J OralMax Sur. 2011; 40(9): 973-978. https://doi.org/10.1016/j.ijom.2011.02.034.
4.    Kumar A, Abbas AK, Jon C. Aster, Robbins SL,Cotran RS. Robbins and Cotran pathologic basis of disease 10th ed. USA: Philadelphia Elseviers Saunders., 2005. pp. 71-110.
5.    Rantam FA, Nugraha AP, Ferdiansyah, Purwati, Bumi C, Susilowati H, Hendrianto E, Utomo DN, Suroto H, Sumartono C, Seiawati R, Prakoeswa CR, Indramaya DM. A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin. Research J. Pharm. and Tech. 2020; 13(1): 275-281
6.    Nugraha AP, Rantam FA, Narmada IB, Ernawati DS, Ihsan IS. Gingival-Derived Mesenchymal Stem Cell from Rabbit (Oryctolaguscuniculus): Isolation, Culture, and Characterization. Eur J Dent. 2021; 15(2): 332-339.
7.    Ahangar P, Mills SJ, Cowin AJ. Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Inter J Mol Sci. 2020; 21(19): 7038. https://doi.org/10.3390/ijms21197038.
8.    Dabrowski FA, Burdzinska A, Kulesza A, Sladowska A, Zolocinska A, Gala K, Paczek L, Wielgos M. Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue. J ObsGyn Res. 2017; 43(11): 1758-68. https://doi.org/10.1111/jog.13432.
9.    Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marbán E. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res. 2010; 106(5): 971-80. https://doi.org/10.1161/CIRCRESAHA.109.210682.
10.    Sagaradze G, Grigorieva O, Nimiritsky P, Basalova N, Kalinina N, Akopyan Z, Efimenko A. Conditioned medium from human mesenchymal stromal cells: towards the clinical translation. Inter JMol Sci. 2019;20(7):1656. https://doi.org/10.3390/ijms20071656.
11.    Bunnell BA. Adipose Tissue-Derived Mesenchymal Stem Cells. Cells. 2021;10(12): 3433. https://doi.org/10.3390/cells10123433.
12.    Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Inter JMol Sci. 2017; 18(9): 1852. https://doi.org/10.3390/ijms18091852.
13.    Hsu PJ, Liu KJ, Chao YY, Sytwu HK, Yen BL. Assessment of the immunomodulatory properties of human mesenchymal stem cells (MSCs). JoVE (Journal of Visualized Experiments). 2015; (106): e53265. doi: 10.3791/53265
14.    Soleymaninejadian E, Pramanik K, Samadian E. Immunomodulatory properties of mesenchymal stem cells: cytokines and factors. Am JRepro Immunol. 2012; 67(1): 1-8. https://doi.org/10.1111/j.1600-0897.2011.01069.x
15.    Anjo SI, Lourenço AS, Melo MN, Santa C, Manadas B. Unraveling mesenchymal stem cells’ dynamic secretome through nontargeted proteomics profiling. InMesenchymal Stem Cells 2016 (pp. 521-549). Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3584-0_32.
16.    Shields AM, Panayi GS, Corrigall VM. Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?.ClinExperImmunol. 2011; 165(3): 292-300. https://doi.org/10.1111/j.1365-2249.2011.04433.x.
17.    Wenzel TJ, Kwong E, Bajwa E, Klegeris A. Resolution-associated molecular patterns (RAMPs) as endogenous regulators of glia functions in neuroinflammatory disease. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 2020; 19(7): 483-94. https://doi.org/10.2174/1871527319666200702143719.
18.    Lee WJ, Tateya S, Cheng AM, Rizzo-DeLeon N, Wang NF, Handa P, Wilson CL, Clowes AW, Sweet IR, Bomsztyk K, Schwartz MW. M2 macrophage polarization mediates anti-inflammatory effects of endothelial nitric oxide signaling. Diabetes. 2015; 64(8): 2836-46.  https://doi.org/10.2337/db14-1668.
19.    Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nature Immunol. 2011; 12(11): 1035-44. https://doi.org/10.1038/ni.2109.
20.    Li M, Hou Q, Zhong L, Zhao Y, Fu X. Macrophage related chronic inflammation in non-healing wounds. FrontImmunol. 2021; 12: 2289. https://doi.org/10.3389/fimmu.2021.681710.
21.    Mortazavi H, Safi Y, Baharvand M, Rahmani S. Diagnostic features of common oral ulcerative lesions: an updated decision tree. Inter J Dent. 2016; 2016. https://doi.org/10.1155/2016/7278925
22.    Hanum F, Ernawati DS, Jusri M. Effectiveness of Probolinggo blue grape (Vitis vinifera) extract on fibroblasts proliferation in traumatic ulcer of Rattusnovergicus albino. Oral Med Dent J. 2013; 4(2): 103-12.
23.    Larasati AR, Soesilawati P, Arundina I. Effect of Stichopushermanii extract to increase re-epithelization in healing process of traumatic ulcer in wistar rat’s oral mucous. Or Bio Jour. 2013; 5(2): 41-46.
24.    Ernawati DS, Puspa A. Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Apismellifera Lawangpropolis extract gel-treated traumatic ulcers in diabetic rats. Vet World. 2018; 11(3): 304. https://dx.doi.org/10.14202%2Fvetworld.2018.304-309
25.    Ganesha R, Hernawan I, Hendarti HT, Radithia D, Hadi P, Ayuningtyas NF, Ernawati DS. Expression of FGF-2 and fibronectin in citrus limon fruit peel malang essential oil gel treated traumatic ulcer in diabetic wistar rats (Rattusnovergicus). Res J Pharm Tech. 2019; 12(7): 3350-4.
26.    Nugraha AP, Rezkita F, Puspitaningrum MS, Luthfimaidah S, Narmada IB, Prahasanti C, Ernawati DS, Rantam FA. Gingival Mesenchymal Stem Cells and Chitosan Scaffold to Accelerate Alveolar Bone Remodelling in Periodontitis: A Narrative Review. Research J. Pharm. and Tech 2020; 13(5):2502-2506.
27.    Suciadi SP, Nugraha AP, Ernawati DS, Ayuningtyas NF, Narmada IB, Prahasanti C, Dinaryanti A, Ihsan IS, Hendrianto E, Susilowati H, Rantam FA.The Efficacy of Human Dental Pulp Stem Cells in regenerating Submandibular Gland Defects in Diabetic Wistar Rats (Rattusnovergicus). Research J. Pharm. and Tech. 2019; 12(4): 1573-1579.
28.    Saputra G, Nugraha AP, Budhy TI, Rosari FS, Lestari NAI, Sari AA, Gheasani A, Valensia T, Ramadhani NF, Noor TNEBTA, Nugraha AP, Nugraha AP, Sosiawan A. Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A Narrative Review. Research Journal of Pharmacy and Technology. 2022; 15(12):5903-8.
29.    Yahya C, Rohman MS, Hidayat M, Nugraha AP, Rantam F. Resveratrol maintain Human Iliac Bone Marrow Mesenchymal Stem Cells Stemness through Sirtuin 1 Mediated Regulation of SRY-Box Transcription Factor 2: an in vitro and in silico study. Research Journal of Pharmacy and Technology. 2022; 15(5):2313-9.
30.    Rezkita F, Wibawa KGP, Nugraha AP. Curcumin loaded Chitosan Nanoparticle for Accelerating the Post Extraction Wound Healing in Diabetes Mellitus Patient: A Review. Research Journal of Pharmacy and Technology, 2020, 13(2): 1039–1042.
31.    Inayati F, Narmada IB, Ardani IGAW, Nugraha AP, Rahmawati D. Post Oral Administration of Epigallocatechin Gallate from Camelia sinensis Extract Enhances Vascular Endothelial Growth Factor and Fibroblast Growth Factor Expression during Orthodontic Tooth Movement in Wistar Rats. JKIMSU 2020; 9(1): 58-65.
32.    Nareswari RAAR, Narmada IB, Djaharu’ddin I, Rahmawati D, Putranti NAR, Nugraha AP. Effect of vitamin D administration on vascular endothelial growth factor expression and angiogenesis number in orthodontic tooth movement of pregnant Wistar rats. 2019; 33(3): 182-8.
33.    Nugraha AP, Susilowati H, Hendrianto E, Karsari D, Ertanti N, Dinaryanti A, Ihsan IS, Narmada IB, Ernawati DS, Rantam FA. Medicinal signaling cells metabolite oral based as a potential biocompatible biomaterial accelerating oral ulcer healing (in vitro study). Eur J Dent. 2019; 13(3): 432-6. doi:10.1055/s-0039-1693923.
34.    Walter MN, Wright KT, Fuller HR, MacNeil S, Johnson WE. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exper Cell Res. 2010; 316(7): 1271-81. https://doi.org/10.1016/j.yexcr.2010.02.026.
35.    Ahangar P, Mills SJ, Smith LE, Strudwick XL, Ting AE, Vaes B, Cowin AJ. Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice. Stem Cell Res Ther. 2020; 11(1): 1-6. https://doi.org/10.1186/s13287-020-01819-z.
36.    Saheli M, Bayat M, Ganji R, Hendudari F, Kheirjou R, Pakzad M, Najar B, Piryaei A. Human mesenchymal stem cells-conditioned medium improves diabetic wound healing mainly through modulating fibroblast behaviors. Arch Dermatol Res. 2020; 312(5): 325-36. https://doi.org/10.1007/s00403-019-02016-6.
37.    Park SR, Kim JW, Jun HS, Roh JY, Lee HY, Hong IS. Stem cell secretome and its effect on cellular mechanisms relevant to wound healing. Mol Ther. 2018; 26(2): 606-17. https://doi.org/10.1016/j.ymthe.2017.09.023.

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