Author(s): Vidhya Rekha Umapathy, Prabhu MN, Bhuminathan. S, Aesa Alzaroug Jaber

Email(s): drvidhyarekha@gmail.com

DOI: 10.52711/0974-360X.2024.00220   

Address: Vidhya Rekha Umapathy1, Prabhu MN2, Bhuminathan. S3, Aesa Alzaroug Jaber4
1Reader, Department of Public Health Dentistry, Thai Moogambigai Dental College and Hospital Dr MGR Educational and Research Institute, Chennai .India
2Assistant Professor in Periodontics, College of Dentistry, Ajman University, Ajman, UAE.
3Department of Prosthodontics, Sree Balaji Dental College and Hospital, BIHER, Pallikaranai, Chennai - 600100, India
4Assistant Professor in Oral Surgery, College of Dentistry, Ajman University, Ajman, UAE
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
According to epidemiological statistics, eating a diet rich in fruits and vegetables can help prevent oral cancer in a variety of ways. Lycopene is a reddish-colored carotenoid found in abundance in tomatoes and other fruits and vegetables. It is reported to be beneficial in the treatment of chronic disorders such as cancer and cardiovascular disease. Hence, the objective of this study is to summarise the lycopene's features and analyse its potential function in the development and treatment of oral precancerous lesions and mouth cancer. Lycopene has been proven to be useful in the treatment of various precancerous lesions in the oral cavity, including oral submucous fibrosis and oral leukoplakia, and could be used in concert with other medications to prevent and treat oral cancer. Lycopene's role in preventing and treating a variety of diseases is still in its infancy, and further study and large-scale clinical trials are needed to substantiate the findings. We explored the effect of Lycopene in oral illness in this review.


Cite this article:
Vidhya Rekha Umapathy, Prabhu MN, Bhuminathan. S, Aesa Alzaroug Jaber. Therapeutic application of Lycopene in preventing Oral diseases- A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1393-7. doi: 10.52711/0974-360X.2024.00220

Cite(Electronic):
Vidhya Rekha Umapathy, Prabhu MN, Bhuminathan. S, Aesa Alzaroug Jaber. Therapeutic application of Lycopene in preventing Oral diseases- A Review. Research Journal of Pharmacy and Technology. 2024; 17(3):1393-7. doi: 10.52711/0974-360X.2024.00220   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-3-71


REFERENCE:
1.    Borse V, Konwar AN, Buragohain P Oral cancer diagnosis and perspectives in India. Sens Int. 2020;1:100046.
2.    Sharma S, Satyanarayana L, Asthana S, Shivalingesh KK, Goutham BS, Ramachandra S. Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries. J. Oral Maxillofac Pathol. 2018;22:18–26.
3.    Melhotra R, Pandya S, Chaudary AK, Kumar M, Singh M. Prevalence of Oral Pre-malignant and Malignant Lesions at a Tertiary Level Hospital in Allahabad, India. Asian Pacific J Cancer Prev. 2008; 9: 263-266.
4.    Kadashetti V, Shivakumar K, Chaudhary M, Patil S, Gawande M, Hande A Influence of risk factors on patients suffering from potentially malignant disorders and oral cancer: a case-control study. J. Oral Maxillofac. Pathol. 2017;21:455–456.
5.    M. A. Fazeelath Banu, Karthikeyan Murthykumar, Dr. Dhanraj. Effect of Lycopene on Oral Lesions : A Short  Review. Research J. Pharm. and Tech. 2016; 9(7):964-966.
6.    Aghel N, Ramezani Z, Amirfakhrian S Isolation and quantification of lycopene from tomato cultivated in Dezfoul, Iran. Jundisha J Nat Pharm Prod. 2011;6:9–15.
7.    Gupta S Jawanda MK Arora V Mehta N Yadav V Role of lycopene in preventing oral diseases as a nonsurgical aid of treatment. Int J Prev Med. 2015;6:70.
8.    Mehta DN Lycopene: Structure, pharmacokinetics and role in oral cancer precancerous lesions. J Res Adv Dent. 2012;1:44–49.
9.    Giovannucci E RESPONSE: Re: Tomatoes, tomato-based products, lycopene, and prostate cancer: Review of the epidemiologic literature. J Natl Cancer Inst. 1999;91:1331A.
10.    Sundus Hameed Ahmed. Bioactivity of Fortified Honey with lycopene extracted from tomatoes Solanum lycopersicum. Research Journal of Pharmacy and Technology. 2021; 14(10):5115-0.
11.    Rao AV, Ray MR, Rao LG. Lycopene. Adv Food Nutr Res 2006; 51: 99–164.
12.    Trumbo PR. Are there adverse effects of lycopene exposure? J Nutr 2005; 135: 2060S–1S.
13.    Stahl W, Sies H Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys 1996; 336: 1–9.
14.    D. A. Bhagwat, N. D. Patil, G. S. Patel, S. G. Killedar, H. N. More. Formulation and Evaluation of Herbal Lipstick using Lycopene Extracted from Solanum lycopersicum L. Research J. Pharm. and Tech. 2017; 10(4): 1060-1064.
15.    Sahana. K. Lycopene as an antioxidant and its medicinal uses. Research J. Pharm. and Tech. 2015; 8(8): 1043-1047.
16.    Woodall AA, Britton G, Jackson MJ Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability. Biochim Biophys Acta 1997; 1336: 575–86.
17.    Heber D, Lu QY Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood). 2002; 227: 920–923.
18.    Matsushima NR, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids. 1995; 30: 1029–1034.
19.    Brienholt V, Lauridsen ST, Daneehvar B, Jakobeen J. Dose-responses effects of lycopene on selected drug metabolizing and antioxidant enzymes in rat. Cancer Lett. 2004; 154: 201–210
20.    Kobayashi T, Iijima K, Mitamura T, Toriizuka K, Cyong JC, Nagasawa H. Effects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4 ⁄ CD8 ratio in a high mammary tumor strain of SHN retired mice. Anticancer Drugs. 1996; 7: 195–198
21.    Gowda BB, Yathish TR, Sankappa PS, Naik HK, Somayaji P, Anand D. The response of oral submucous fibrosis to lycopene – A carotenoid antioxidant: A clinicopathological study. J Clin Diagn Res. 2011; 5: 882–886
22.    Antioxidants and Oral Cancer - A Review. Research J. Pharm. and Tech. 2016; 9(8): 1287-1290.
23.    D’Ambriosio SM, D’Ambriosio RG, Milo GE, Casto B, Kelloff GJ, Steele VE. Differential response of normal, premalignant human oral epithelia cells to growth inhibition by chemopreventive agents. Anticancer Res. 2000; 20: 2273–2280.
24.    Bansal M, Vashisth S, Gupta N, Singh S. Antioxidants – Its preventive role in oral cancer. Indian J Dent Sci. 2012;4:103–105
25.    Palozza P, Simone RE, Catalano A, Mele MC. Tomato lycopene and lung cancer prevention: From experimental to human studies. Cancers (Basel). 2011; 3:2333–2357.
26.    Livny O, Kaplan L, Reifen R, Polak-Charcon S, Madarand Z, Schwartz B. Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells. J Nutr. 2002; 132: 3754–379.
27.    Singh M, Krishanappa R, Bagewadi A, Keluskar V. Efficacy of oral lycopene in the treatment of oral leukoplakia. Oral Oncol. 2004; 40: 591–596.
28.    Rekha UV, Anita M, Bhuminathan S, Sadhana K. Molecular docking analysis of human JAK2 with compounds from tomatoes. Bioinformation. 2020; 16(10): 742-747.
29.    Ribeiro AS, Salles PR, da Silva TA, Mesquita RA. A review of the nonsurgical treatment of oral leukoplakia. Int J Dent. 2010; 2010: 186018.
30.    Reibel J. Prognosis of oral pre-malignant lesions: Significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med. 2003;14:47–62
31.    van der Waal I, Schepman KP, van der Meij EH, Smeele LE. Oral leukoplakia: A clinicopathological review. Oral Oncol. 1997;33:291–301
32.    Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002; 52:195–215.
33.    Ishii J, Fujita K, Komori T. Laser surgery as a treatment for oral leukoplakia. Oral Oncol. 2003;39:759–69.
34.    Monica Chopra, Asish Bhaumik, A. Gopi Reddy, P. Sravan Kumar, B. Srikant. Extraction and Isolation of Bioactive Molecule Lycopene from Water Melon and Evaluation of Anti Diabetic Activity against STZ Induced Rats.Research J. Pharm. and Tech. 2018; 11(1):101-106.
35.    Anup A. Patil, Rajendra Doijad, Akshada Koparde. Renoprotective effect of Lycopene on Renal Functional and Histopathological changes in Gentamycin Induced Nephrotoxicity in Rats. Research J. Pharm. and Tech. 2020; 13(7): 3237-3240.
36.    Nagao T, Ikeda N, Warnakulasuriya S, Fukano H, Yuasa H, Yano M, et al. Serum antioxidant micronutrients and the risk of oral leukoplakia among Japanese. Oral Oncol. 2000; 36: 466–70.
37.    Gupta PC, Hebert JR, Bhonsle RB, Sinor PN, Mehta H, Mehta FS. Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. Oral Dis. 1998; 4: 200–206.
38.    Aung WP. The use of lycopene in oral potentially malignant disorders. Myan Dent J. 2013; 20: 58–63.
39.    Zakrzewska JM. Oral lycopene – An efficacious treatment for oral leukoplakia? Evid Based Dent. 2005; 6: 17–8
40.    Vidhya Rekha U, Prabhu MN, Bhuminathan. S. Review on Anticancer properties of Piperine in Oral cancer: Therapeutic Perspectives. Research Journal of Pharmacy and Technology. 2022; 15(7): 3338-2.
41.    Koshti SS, Barpande S Quantification of plasma fibrinogen degradation products in oral submucous fibrosis: A clinicopathological study. J Oral Maxillofac Pathol. 2007; 11: 48–50.
42.    Nirisha Sriram, Gheena. S, Samrithi Yuvaraj. Effects of turmeric on oral submucous fibrosis: A Systematic Review. Research J. Pharm. and Tech. 2015; 8(8): 1051-1055.
43.    Kuo MY, Chen HM, Hahn LJ, Hsieh CC, Chiang CP Collagen biosynthesis in human oral submucous fibrosis fibroblast cultures. J Dent Res. 1995; 74: 1783–8
44.    Trivedy C, Meghji S, Warnakulasuriya KA, Johnson NW, Harris M Copper stimulates human oral fibroblasts in vitro: A role in the pathogenesis of oral submucous fibrosis. J Oral Pathol Med. 2001; 30: 465–70.
45.    Borle RM, Borle SR Management of oral submucous fibrosis: A conservative approach. J Oral Maxillofac Surg. 1991; 49: 788–91.
46.    Kumar A, Bagewadi A, Keluskar V, Singh M Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103: 207–13.
47.    Gorsky M, Raviv M Efficacy of etretinate (Tigason) in symptomatic oral lichen planus. Oral Surg Oral Med Oral Pathol. 1992; 73: 52–5.
48.    Sander CS, Ali I, Dean D, Thiele JJ, Wojnarowska F. Oxidative stress is implicated in the pathogenesis of lichen sclerosus. Br J Dermatol. 2004; 151: 627–35.
49.    Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, et al. Update on oral lichen planus: Etiopathogenesis and management. Crit Rev Oral Biol Med. 1998; 9: 86–122.
50.    Levy J, Sharoni Y. The functions of tomato lycopene and its role in human health. Herbalgram. 2004; 62: 49–56
51.    Sheik Abdulazeez Sheriff, Thiruvengadam Devaki. Effect of Lycopene on General Clinical Parameters During D-galactosamine/ Lipopolysaccharide (D-GalN/LPS) Induced Hepatitis in Rats. Research J. Pharm. and Tech. 2012; 5(3): 398-403.
52.    Chapple IL. Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseases. Clin Mol Pathol. 1996; 49: M247–455.
53.    Dahan K, Fennal M, Kumar NB. Lycopene in the prevention of prostate cancer. J Soc Integr Oncol. 2008; 6: 29–36.
54.    Sung WS, Lee IS, Lee DG. Damage to the cytoplasmic membrane and cell death caused by lycopene in Candida albicans. J Microbiol Biotechnol. 2007; 17: 1797–804.
55.    Chandra RV, Prabhuji ML, Roopa DA, Ravirajan S, Kishore HC. Efficacy of lycopene in the treatment of gingivitis: A randomised, placebo-controlled clinical trial. OralHealth Prev Dent.2007;5:327–36.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available