Author(s): Abarnadevika A, Mathuraveendran T, Ariharasivakumar G, Srinidhi R

Email(s): abarnadevika@gmail.com

DOI: 10.52711/0974-360X.2024.00217   

Address: Abarnadevika A, Mathuraveendran T, Ariharasivakumar G, Srinidhi R
A. Abarnadevika, Department of Pharmacology, KMCH College of Pharmacy, Coimbatore, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
Leaves of Nephelium lappaceum L. Family Sapindaceae has been traditionally used in many Asian countries for several therapeutic purposes. However, the antidiabetic activity of leaf has not been scientifically investigated so far. The aim of this study therefore, was to evaluate the antidiabetic activity of methanolic leaf extract of Nephelium lappaceum (MLEN) against streptozotocin (STZ) - nicotinamide (NIC) induced type II diabetes in albino rats. Non-insulin dependent diabetes mellitus was induced in overnight fasted rats by a single intraperitoneal injection of 60mg/kg streptozotocin 15min after the i.p administration of 120mg/kg of nicotinamide. The diabetic rats were treated with 28 days by the oral administration of methanolic leaf extract of Nephelium lappaceum L. (400 and 800mg/kg/b.w). In glucose to tolerance test, MLEN markedly reduced the external glucose load. Fasting blood glucose level, body weight were monitored every 7 days during the treatment. At the end of the study fasting blood glucose level, haemoglobin, HbA1c, kidney (urea, creatinine) functional test, liver (SGOT, SGPT) functional test and in vivo antioxidant markers (GSH, CAT, SOD, Vitamin C and LPO) were estimated. Histopathology of pancreas was carried out to assess antidiabetic effect of MLEN. After treatment with MLEN fasting blood glucose, HbA1c levels, SGOT, SGPT and LPO were significantly decreased in diabetic rats. However, haemoglobin, CAT and GSH levels were significantly increased in MLEN treated diabetic rats. The histopathological study of the pancreas in extract treated diabetic group’s revealed regeneration of beta cells. The methanolic leaf extract of Nephelium lappaceum L. was evaluated for its effect on blood sugar, against the STZ –NIC induced diabetic rats and compared it with standard drug metformin. The result of this experimental study concluded that MLEN of Nephelium lappaceum L. leaves possess safe and strong antidiabetic activity against STZ-NIC induced diabetic rats.


Cite this article:
Abarnadevika A, Mathuraveendran T, Ariharasivakumar G, Srinidhi R. Evaluation of Antidiabetic Activity of Methanolic Leaf Extract of Nephelium lappaceum L. against Streptozotocin-Nicotinamide Induced Type-II Diabetes in Wistar Albino Rats. Research Journal of Pharmacy and Technology. 2024; 17(3):1376-1. doi: 10.52711/0974-360X.2024.00217

Cite(Electronic):
Abarnadevika A, Mathuraveendran T, Ariharasivakumar G, Srinidhi R. Evaluation of Antidiabetic Activity of Methanolic Leaf Extract of Nephelium lappaceum L. against Streptozotocin-Nicotinamide Induced Type-II Diabetes in Wistar Albino Rats. Research Journal of Pharmacy and Technology. 2024; 17(3):1376-1. doi: 10.52711/0974-360X.2024.00217   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-3-68


REFERENCES:
1.    Undale VR, Kurkute SS, Jadhav SS. Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats. Research Journal of Pharmacy and Technology. 2020; 13(6): 2591-6.
2.    Das U, Kaur J, Vyas M, Verma S, Khatik G. Identification of Glucagon-Like Peptide-1 (GLP-1) receptor agonists as a potential antidiabetic agent through molecular docking. Research Journal of Pharmacy and Technology. 2020; 13(10): 4770-6.
3.    Annapurna MM, Naik RR, Pratyusha SM. Simultaneous spectrophotometric determination of compounds: Applic ation to an anti-diabetic formulation of Teneligliptin and Metformin. Research Journal of Pharmacy and Technology. 2020; 13(4): 1938-42.
4.    Ramu Singh D, Gupta PP, Roy A, Chandrakar S. Evaluation of In vivo Antidiabetic activity of extract of herbal formulation obtained from Hathbandh dist. Baloda Bazaar on streptozotozcin-induced diabetic rats.
5.    Dubey SK, Batra A. Anti diabetic activity of Thuja occidentalis Linn. Research Journal of Pharmacy and Technology. 2008; 1(4): 362-5.
6.    Jain A, Chaudhary J, Saini A, Mehan N. Quality Assessment and Comparative Study of different Marketed Brands of Metformin. Research Journal of Pharmacy and Technology. 2019; 12(3): 1357-60.
7.    Kulkarni SV, Patel N. Formulation and Evaluation of Locust Bean Gum Based Matrix Tablets for Oral Controlled Delivery of Metformin Hydrochloride and Its Comparison with Marketed Product. Research Journal of Pharmacy and Technology. 2010; 3(4): 1082-7.
8.    Cetin M, Sahin S. Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride. Drug delivery. 2016; 23(8): 2796-805.
9.    Ahmed D, Makhous R. Evaluation of the effect of Metformin therapy on TSH serum levels in Diabetic patients. Research Journal of Pharmacy and Technology. 2020; 13(8): 3801-6.
10.    Jain AK, Sharma N, Upadhyay A, Dixit A. Hypoglycemic activity of Curculigo orchioides Gaertn in normal and streptozotocin induced diabetic rats. Research Journal of Pharmacy and Technology. 2010; 3(1): 133-5.
11.    Beckmann R: Biguanide (ExperimentellerTeil). Handbook of Experimental Pharniacology. 1971; 29: 439-596.
12.    Mehnert H, Haese EG: Biguanide (KlinischerTeil). Handbook of Experimental Pharnmcology. 1971; 29:  597- 657.
13.    Williams RH, Palmer JP: Farewell to phenformin for treating diabetes mcllitus. Ann Intern Med. 1975; 83:567-68.
14.    Nattrass M, Alberti KGMM: Biguanides. Diabetologia. 1978;  14: 71-74.
15.    Raptis AE, Tountas N, Yalouris AG, Hadjidakis D, Zaharis A, Miras K, Raptis SA: Comparative study of the therapeutic effects of glibenclamide or the fixed combination glibenclamide-phenformin with those of gliclazide or chlorpropamide. ActaDiahctolIxit.  1990; 27:11- 22.
16.    Sruthi DR, Indira G. A comparative evaluation of maceration, soxhlation and ultra sound assisted extraction for the phytochemical screening of the leaves of Nephelium lappaceum. L.(Sapindaceae). Journal of Pharmacognosy and Phytochemistry. 2016; 5(5): 386.
17.    Chigurupati S, Vijayabalan S, Selvarajan KK, Hashish NE, Mani V, Ahmed ES, Das S. Identification of Nephelium lappaceum leaves phenolic and flavonoid component with radical scavenging, antidiabetic and antibacterial potential.
18.    D.L.Coleman, K.P Hummel: Studies with the mutation diabetes in the mouse. Diabetologia 1967; 3: 238-248.  
19.    Prashant Singh Chauhan, Naresh Kumar Satti, Vijay Kumar Sharma, PrabhuDutt, Krishan Avtar Suri and SarangBani. Amelioration of inflammatory responses by Chlorogenic acid via suppression of pro-inflammatory mediators. Journal of Applied Pharmaceutical Science. 2011; 1(4): 67-75
20.    Reaven G, Abbasi F, and McLaughlin T. Obesity, insulin resistance, and cardiovascular disease. Recent Progress in Hormone Research. 2004;  59: 207–223, 2004.
21.    Humphrey P. Rang, M. Maureen Dale, J. M. Ritter, R. J. Flower, Pharmacology, Churchill Livingstone, Philadelphia, Pa, USA, 2007.
22.    Jia J, Zhang X, Hu Y, Wu Y, Wang Q, Li N, et al. Evaluation of invivo antioxidant activities of Ganodermalucidum polysaccharide in STZ-diabetic rats. Food Chem.  2009; 115: 32-6.


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