Author(s):
Soumaya El Baraka, Ali Cherif Chefchaouni, Ismail Bennani, Aicha Fahry, Abdelkader Laatiris, Naoual Cherkaoui, Yasser El Alaoui, Younes Rahali
Email(s):
soumayaelbaraka23@gmail.com
DOI:
10.52711/0974-360X.2024.00188 
Address:
Soumaya El Baraka1, Ali Cherif Chefchaouni1, Ismail Bennani2, Aicha Fahry1, Abdelkader Laatiris1, Naoual Cherkaoui1, Yasser El Alaoui1, Younes Rahali1
1Team of Formulation and Quality Control of Health Products, Laboratory of Pharmaceutics, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco.
2Galenic laboratory of Faculty of Medicine and Pharmacy of Fez, Mohammed Sidi Benabdellah University of Fez.
*Corresponding Author
Published In:
Volume - 17,
Issue - 3,
Year - 2024
ABSTRACT:
Objective: Drugs classified as Class II and IV on the Biopharmaceutical Classification System are commonly associated with solubility challenges. This research aims to investigate the impact of cyclodextrin combined with both PEG 4000 and SLS, individually and in combination, on the enhancement of solubility and dissolution rate of three drugs belonging to BCS Class II (celecoxib and Valsartan) and Class IV (Furosemide). Methods: A series of 23 factorial experiments were conducted to assess drug solubility in eight selected fluids containing Beta Cyclodextrin, Poly Ethylene Glycol 4000, Sodium Lauryl Sulphate, both separately and in binary and ternary combinations. Solid inclusion complexes of each drug with beta Cyclodextrin, PEG 4000 and SLS were prepared using the kneading method. The impact of each excipient on dissolution rates was evaluated through a23 factorial design. Results: The presence of the studied excipients significantly improved the solubility of the three drugs under investigation. Celecoxib solubility was highly enhanced by Cyclodextrin combined toPEG 4000 and SLS(2,77 ratio). Furosemide solubility was highly enhanced by Cyclodextrin combinedto SLS (ac) (2,96 ratio). And valsartan solubility by beta cyclodextrin combined to PEG 4000 and SLS(2,43 ratio). Among dissolution rates, the addition of PEG 4000 and SLS alongside Cyclodextrin led to even more substantial improvements: 14.96-ratio and 7.34-ratio enhancements, respectively on celecoxib dissolution rates, and 9,22-ratio and 11,73-ratio increases, respectively, for furosemide dissolution rates, then.2,09-ratio and 1,88-ratio, respectively on valsartan dissolution rates. Conclusion: Sodium Lauryl Sulphate demonstrates efficacy as a solubilizer both independently and in conjunction with ßCD and PEG 4000, effectively enhancing the solubility and dissolution rate of the selected BCS Class II and IV drugs.
Cite this article:
Soumaya El Baraka, Ali Cherif Chefchaouni, Ismail Bennani, Aicha Fahry, Abdelkader Laatiris, Naoual Cherkaoui, Yasser El Alaoui, Younes Rahali. The use of Cyclodextrin-SLS-PEG 4000 Complex to Solubilize Three BCS Class II and IV Drug´S through A Factorial Study Design. Research Journal of Pharmacy and Technology.. 2024; 17(3):1207-1. doi: 10.52711/0974-360X.2024.00188
Cite(Electronic):
Soumaya El Baraka, Ali Cherif Chefchaouni, Ismail Bennani, Aicha Fahry, Abdelkader Laatiris, Naoual Cherkaoui, Yasser El Alaoui, Younes Rahali. The use of Cyclodextrin-SLS-PEG 4000 Complex to Solubilize Three BCS Class II and IV Drug´S through A Factorial Study Design. Research Journal of Pharmacy and Technology.. 2024; 17(3):1207-1. doi: 10.52711/0974-360X.2024.00188 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-3-39
REFERENCES:
1. Karajgi S, Hajeri S, Potadar S. Utilization of Hydrotropic Solubilisation Technique for Quantitative Studies of Dexamethasone in Pharmaceutical preparations. Res J Pharm Technol. 2022;15(12):5785–5788. doi.org/ 10.52711/0974-360X.2022.00976
2. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12(23–24):1068–1075. doi.org/10.1016/j.drudis.2007.09.005
3. Serajuddin AT. Salt formation to improve drug solubility. Adv Drug Deliv Rev. 2007; 59(7): 603–616. doi.org/10.1016/j.addr.2007.05.010
4. Jouyban A. Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures. J Pharm Pharm Sci. 2008; 11(1): 32–58. 10. doi.org/18433/j3pp4k
5. Shaikh FI, Patel MB, Surti NI, Patel VB. Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution. Res J Pharm Technol. 2017; 10(4): 1041–1048. doi.org/10.5958/0974-360X.2017.00189.5
6. Sharma A, Rastogi V, Kumar P, Prasad N. Formulation approaches for solubility enhancement by using polar or non-polar lipid components of bcs class ii drugs through lbdds. Res J Pharm Technol. 2020; 13(8): 3918–3928. doi.org/10.5958/0974-360X.2020.00694.0
7. Kishore G, Shyale S, Srikanth K, Gupta VRM. Development and Evaluation of Colon Targeted Tablets of Praziquantel and its β-Cyclodextrin Complex for the Treatment of Schistosomiasis. Res J Pharm Technol. 2010; 3(4): 1270–1274. Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-4-171
8. Cavalli R, Trotta F, Tumiatti W. Cyclodextrin-based nanosponges for drug delivery. J Incl Phenom Macrocycl Chem. 2006; 56: 209–213. doi.org/ 10.1007/s10847-006-9085-2
9. Kumar AY, Setty CM. Preparation and Evaluation of Nateglinide-Cyclodextrin Inclusion Complex. Res J Pharm Technol. 2018; 11(3): 1017–1022. doi.org/10.5958/0974-360X.2018.00190.7
10. Rathi S, Patel D, Shah S. Physicochemical characterization and in-vitro dissolution behavior of artemether and lumefantrine: hydroxypropyl-β-cyclodextrin inclusion complex. Res J Pharm Technol. 2020; 13(3): 1137–1141. doi.org/10.5958/0974-360X.2020.00209.7
11. Alizadeh MN, Shayanfar A, Jouyban A. Solubilization of drugs using sodium lauryl sulfate: Experimental data and modeling. J Mol Liq. 2018;268:410–414.doi.org/10.1016/j.molliq.2018.07.065
12. Alrouhayyah R, Sheshko TF, Suslina SN. Improving the Dissolution rate of Mefenamic acid by preparing Solid Dispersions with Polyethylene glycol 4000. Res J Pharm Technol. Research Journal of Pharmacy and Technology; 2023; 16(7):3115–3119. doi.org/10.52711/0974-360X.2023.00512
13. Kumar AP, Satyanaryana J, Kishore VS, Murthy TE. Formulation and Evaluation of Valsartan Fast Dissolving Tablets. Res J Pharm Technol. 2011; 4(3): 454–456.
14. Chaulang G, Patil K, Ghodke D, Khan S, Yeole P. Preparation and characterization of solid dispersion tablet of furosemide with crospovidone. Res J Pharm Technol. 2008; 1(4): 386–389. Available on: https://rjptonline.org/AbstractView.aspx?PID=2008-1-4-73
15. Madoria N, Maheshwari Y. Formulation, Optimization and Characterization of Fast Dissolving Tablet of Celecoxib. Res J Pharm Technol. 2012; 5(8): 1085–1088.
16. Lee JH, Kim MJ, Yoon H, Shim CR, Ko HA, Cho SA, Lee D, Khang G. Enhanced dissolution rate of celecoxib using PVP and/or HPMC-based solid dispersions prepared by spray drying method. J Pharm Investig. 2013; 43: 205–213. doi.org/10.1007/s40005-013-0067-2
17. Jagtap VA, Talele AN, Bendale AR, Narkhede S, Jadhav A, Vidyasagar G. Solubility Enhancement of Pioglitazone by Using Poloxamer (188 and 407) with the Help of Kneading Method. Res J Pharm Technol. 2010; 3(4): 1152–1157. Available on: https://rjptonline.org/AbstractView.aspx?PID=2010-3-4-146