Author(s):
Job Herman Berkhout, Aswatha Ram H.N.
Email(s):
aswatharam@gmail.com
DOI:
10.52711/0974-360X.2024.00159 
Address:
Job Herman Berkhout1, Aswatha Ram H.N.2*
1Faculty of Science, Radboud University, Nijmegen, the Netherlands.
2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 3,
Year - 2024
ABSTRACT:
The ionization state (pKa) of a compound influences its absorption, distribution, metabolism and excretion. Therefore, proper knowledge of the pKa is crucial in understanding the behavior of a compound behavior inside the body. In this research paper, we validate the pKa of muscarinic acetylcholine receptor antagonist atropine sulfate using Uv-Vis spectroscopy, to validate the use of this method and to re-evaluate the of atropine sulfate. The pKa value from absorption measurements is first estimated using 3rd degree polynomial and then precisely calculated according to the Albert-Sergeant method. We established that the pKa value of Atropine sulfate is 9.94±0.050 which is comparable to the values present in the literature.
Cite this article:
Job Herman Berkhout, Aswatha Ram H.N.. Research Journal of Pharmacy and Technology. 2024; 17(3):1029-2. doi: 10.52711/0974-360X.2024.00159
Cite(Electronic):
Job Herman Berkhout, Aswatha Ram H.N.. Research Journal of Pharmacy and Technology. 2024; 17(3):1029-2. doi: 10.52711/0974-360X.2024.00159 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-3-10
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