Author(s): Tridiganita Intan Solikhah, Gahastanira Permata Solikhah

Email(s): tridiganita-intan-s@fkh.unair.ac.id

DOI: 10.52711/0974-360X.2024.00112   

Address: Tridiganita Intan Solikhah1,2*, Gahastanira Permata Solikhah3
1Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia.
2Faculty of Health, Medicine, and Life Science, Universitas Airlangga, Indonesia.
3Cahaya Petclinic, Veterinarian, Mojokerto, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
Hyperlipidemia is a risk factor of cardiovascular disorder in diabetes mellitus. Lack of insulin in diabetes mellitus can increase lipolysis which leads to an increased free fatty acid that also increases total cholesterol level and LDL (Low-Density Lipoprotein). This study aims to determine the effect of Muntingia calabura leaf extract on the level of total cholesterol (TC), triglycerides (TG), LDL, and High Density Lipoproteins (HDL) of alloxan-induced male white mice. Thirty male mice were separated into five groups: negative control (NC) without alloxan and extract, diabetes control (DC) with only alloxan, treatment 1 (T1) with alloxan and 100mg/kgBW of M. calabura leaf extract, treatment 2 (T2) with alloxan and 300 mg/kgBW of M. calabura leaves extract, and positive control (PC) with alloxan and 600 µg/kgBW of glibenclamide. One-Way Anova demonstrated that the administration of glibenclamide and M. calabura effectively reduce TC, TG, LDL and increase HDL compared to the diabetes control group (P<0.05) and the most effective dose M. calabura to decrease TC, TG, LDL, and to increase HDL were 300 mg/kgBW. Extraction using 96% ethanol of M. calabura leaf affects the reduction of TC, TG, LDL, and the increase of HDL in the blood and it can be developed as alternative of antihyperlipidemia drugs.


Cite this article:
Tridiganita Intan Solikhah, Gahastanira Permata Solikhah. Effect of Ethanol Extract from Kersen Leaves (Muntingia calabura L.) on Changes in Blood Factors Total Cholesterol, Triglycerides, LDL and HDL in Hyperlipidemia Mice. Research Journal of Pharmacy and Technology. 2024; 17(2):723-6. doi: 10.52711/0974-360X.2024.00112

Cite(Electronic):
Tridiganita Intan Solikhah, Gahastanira Permata Solikhah. Effect of Ethanol Extract from Kersen Leaves (Muntingia calabura L.) on Changes in Blood Factors Total Cholesterol, Triglycerides, LDL and HDL in Hyperlipidemia Mice. Research Journal of Pharmacy and Technology. 2024; 17(2):723-6. doi: 10.52711/0974-360X.2024.00112   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-2-40


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