Author(s):
Shankar S. Khandare, Rajesh B. Jadhav, Kavita A. Pimpre, Anirudha V. Munde, Shivkanya S Chandrawanshi, Mahavir H Ghante
Email(s):
sskhandare77@gmail.com
DOI:
10.52711/0974-360X.2024.00109 
Address:
Shankar S. Khandare1*, Rajesh B. Jadhav2, Kavita A. Pimpre3, Anirudha V. Munde4, Shivkanya S Chandrawanshi5, Mahavir H Ghante6
1SCES,s Indira College of Pharmacy, Pune.
2Raosaheb Patil Danve College of Pharmacy, Badnapur.
3National Institute of Pharmaceutical Education and Research, Hyderabad.
4SCES,s Indira College of Pharmacy, Pune.
5SCES,s Indira College of Pharmacy, Pune.
6Nanded Pharmacy College, Nanded.
*Corresponding Author
Published In:
Volume - 17,
Issue - 2,
Year - 2024
ABSTRACT:
Pithecellobium dulce (PD), commonly known as Jangli-jilebi, is a Manila tamarind belonging to the family Leguminosae. P. dulce (PD) is used to treat various diseases like diarrhea, asthma, leprosy, paralysis, inflammatory, anti-bacterial, spermicidal, anti-convulsant, etc. In this paper, we studied the activity of P. Dulce for depression, which is a debilitating, life-threatening, and common disease affecting different sections of the community. Chemical and synthetic medications used to treat this disease have significant negative side effects, and only 50–60% of patients fully recover. At the same time, the available scientific information about this species is scarce, and there are no reports related to its possible effects on the central nervous system. In this work, the effects of acetone and methanolic extracts of the stem bark of P. dulce (PD) were evaluated in mice and rats utilizing behavioral assays sensitive to clinically effective anti-depressant compounds. In both the forced swim test and the tail suspension test, the extracts (100 and 200 mg/kg) administered orally were able to shorten the immobility duration of mice and rats in a dose-dependent manner. According to the current study's findings, PD extract may have antidepressant potential and be useful in treating those who suffer from depressive disorders. These findings proved that PD has specifically anti-depressive in vivo effects.
Cite this article:
Shankar S. Khandare, Rajesh B. Jadhav, Kavita A. Pimpre, Anirudha V. Munde, Shivkanya S Chandrawanshi, Mahavir H Ghante. Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats. Research Journal of Pharmacy and Technology. 2024; 17(2):703-6. doi: 10.52711/0974-360X.2024.00109
Cite(Electronic):
Shankar S. Khandare, Rajesh B. Jadhav, Kavita A. Pimpre, Anirudha V. Munde, Shivkanya S Chandrawanshi, Mahavir H Ghante. Pharmacological Investigation of Pithecellobium dulce Stem Bark extract for Anti-Depressant Activity on Mice and Rats. Research Journal of Pharmacy and Technology. 2024; 17(2):703-6. doi: 10.52711/0974-360X.2024.00109 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-2-37
REFERENCE:
1. Reynolds EH. Brain and mind: a challenge for WHO. Lancet 2003; 361: 1924‐1925.
2. V. H. Pushpa et al. Antidepressant activity of methanolic extract of Acorus calamus leaves in Albino mice. Int. J. Pharm. Technol. 2013; 5(2): 5458–5465,.
3. Thase ME, Howland RH. Biological processes in depression: an update and integration. In: Beckham EE, Leber WR, editors. Handbook of Depression, 2nd ed., New York, Guilford, 1995; 213–279.
4. Yu ZF, Kong LD and Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. Ethnopharmocol. 2002; 83: 161.
5. V. S. K. Sneha, Dontharaboina, Singarapu Prashanth and N. Boggula. Systematic Review of Pithecellobium Dulce (Roxb.) Benth.: a Traditional Medicinal Herb. J. Innov. Dev. Pharm. Tech. Sci. 2020; 3(5): 1–9 Available: https://jidps.com/wpcontent/uploads/2020/05/Systematic-Review-of-Pithecellobiumdulce-ROXB.-Benth-A-TRADITIONAL-Medicinal-HERB.pdf.
6. N. Road. J. Glob. Trends Pharm. Sci. 2014; 5(1):1399–1404.
7. D. A. Slattery and J. F. Cryan. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat. Protoc. 2012; 7(6): 1009–1014 doi: 10.1038/nprot.2012.044.
8. A. Kaltenboeck and C. Harmer. The neuroscience of depressive disorders: A brief review of the past and some considerations about the future. Brain Neurosci. Adv. 2018; 2: 239821281879926 doi: 10.1177/2398212818799269.
9. M. Aslam. Tail suspension test to evaluate the antidepressant activity of experimental drugs. Bangladesh J. Pharmacol. 2016; 11(2): 292–294 doi: 10.3329/bjp.v11i2.26517.
10. G. Gupta, T. Jia Jia, L. Yee Woon, D. Kumar Chellappan, M. Candasamy, and K. Dua. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Adv. Pharmacol. Sci. 2015 doi: 10.1155/2015/164943.
11. V. S. K. Sneha, Dontharaboina, Singarapu Prashanth and N. Boggula. Systematic Review of Pithecellobium Dulce (Roxb.) Benth.: a Traditional Medicinal Herb. J. Innov. Dev. Pharm. Tech. Sci. 2020;3(5): 1–9 Available: https://jidps.com/wp-content/uploads/2020/05/Systematic-Review-Of-Pithecellobium-Dulce-Roxb.-Benth-A-Traditional-Medicinal-HERB.pdf
12. D. M. Nagmoti and A. R. Juvekar. In vitro inhibitory effects of Pithecellobium dulce (Roxb.) Benth. seeds on intestinal α-glucosidase and pancreatic α-amylase. 2013;4: 616–621.
13. Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl.). 1988; 94: 147–60.
14. Brunello N, Mendlewicz J, Kasper S, Leonard B, Montgomery S, et al. The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. European Neuropsychopharmacology. 2002; 12: 461–75.