Author(s):
Biswajit Banerjee, Tripti Sharma, Ipsa Padhy, Arijit Mondal, Anup Choudhury
Email(s):
anupchoudhury113@gmail.com
DOI:
10.52711/0974-360X.2024.00107 
Address:
Biswajit Banerjee1, Tripti Sharma1, Ipsa Padhy1, Arijit Mondal2, Anup Choudhury3*
1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), BBSR, Odisha – 751003.
2Department of Pharmaceutical Chemistry, M.R. College of Pharmaceutical Sciences and Research, Balisha, West Bengal – 743234.
3Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal -713212.
*Corresponding Author
Published In:
Volume - 17,
Issue - 2,
Year - 2024
ABSTRACT:
The novel imidazole topical drug luliconazole (LCZ) has potent antifungal efficacy against a wide variety of fungi. When applied to the skin, LCZ has tremendous promise as an antifungal agent, however, constrained by its poor skin permeability and limited solubility, requiring protracted therapy and repeated dosage to achieve full recovery. The current work explains the formulation and characterization of a cationic gel prepared by using Guar Gum (GG) and pH was adjusted by using NaOH solution. The created formulation was white in color. The FTIR spectroscopy analysis shows that the medication and polymer did not react with one another. The cumulative percentage drug release suggested that LCZ was released from the formulations. All the release kinetics show that drug release from the formulation was in Fickian transport nature. The correlation value was found to be more than 0.90 in all the fitted release models. The pH of each formulation fell within the predetermined range.The prepared LCZ gel shows a viscosity between 13000 to 28000 cps, which is a very good topical application.
Cite this article:
Biswajit Banerjee, Tripti Sharma, Ipsa Padhy, Arijit Mondal, Anup Choudhury. Fabrication and Evaluation of Luliconazole contains Cationic Guar Gum intended to use for Topical application. Research Journal of Pharmacy and Technology. 2024; 17(2):693-8. doi: 10.52711/0974-360X.2024.00107
Cite(Electronic):
Biswajit Banerjee, Tripti Sharma, Ipsa Padhy, Arijit Mondal, Anup Choudhury. Fabrication and Evaluation of Luliconazole contains Cationic Guar Gum intended to use for Topical application. Research Journal of Pharmacy and Technology. 2024; 17(2):693-8. doi: 10.52711/0974-360X.2024.00107 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-2-35
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