Author(s): Ulfa Elfiah, David Sontani Perdanakusuma, Iswinarno Doso Saputro, Misnawi

Email(s): ulfa.elfiah-2019@fk.unair.ac.id , dperdanakusuma@fk.unair.ac.id

DOI: 10.52711/0974-360X.2024.00099   

Address: Ulfa Elfiah1,2, David Sontani Perdanakusuma3, Iswinarno Doso Saputro3, Misnawi4
1Faculty of Medicine, Universitas Jember, Jalan Kalimantan No. 37, Jember, East Java, Indonesia.
2Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen. Prof. Dr. Moestopo 47 Surabaya, East Java, Indonesia.
3Reconstructive And Aesthetic Plastic Surgery, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen. Prof. Dr. Moestopo 47 Surabaya, East Java, Indonesia.
4Indonesian Coffee and Cocoa Research Institute, Jl. PB. Sudirman 90, Jember, East Java, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
This study compares the anti-hyperpigmentation activity of kojic acid and Robusta BP-42 coffee bean extract on skin-grafted rats. Kojic acid is one of the standards for reducing pigmentation on the skin. But, kojic acid usage presents side effects for some patients, such as skin irritation, redness, and itching. Robusta BP-42 is one of the best robusta coffee strains found in Indonesia. The Indonesian Coffee and Cocoa Research Institute, Jember Regency, East Java, provides this coffee. BP-42 coffee has the highest quality grain and organoleptic score compared to other strains. Three groups of grafted skin on long Evans rats were treated with 2% kojic acid gel (positive control), 5% robusta BP-42 coffee extract gel, and placebo gel (negative control). Observation occurred for 21 days. The photos of grafted skin were taken on days 0, 4, 7, 11, 18 and 21. Skin pigmentation was measured using ImageJ software. Histological examination was performed on days 7, 14, and 21 for all treatment groups. These histological preparations were stained with Masson Fontana. The result showed that Robusta BP-42 coffee extract gel showed a similar clinical and histological measurement to positive control. Robusta BP-42 coffee can be a new candidate to treat hyperpigmentation after skin graft surgery


Cite this article:
Ulfa Elfiah, David Sontani Perdanakusuma, Iswinarno Doso Saputro, Misnawi. Anti-inflammation and Anti-tyrosinase effect of Robusta coffee BP-42 extract gel on clinical appearance after skin grafting in long evans rats. Research Journal of Pharmacy and Technology. 2024; 17(2):636-2. doi: 10.52711/0974-360X.2024.00099

Cite(Electronic):
Ulfa Elfiah, David Sontani Perdanakusuma, Iswinarno Doso Saputro, Misnawi. Anti-inflammation and Anti-tyrosinase effect of Robusta coffee BP-42 extract gel on clinical appearance after skin grafting in long evans rats. Research Journal of Pharmacy and Technology. 2024; 17(2):636-2. doi: 10.52711/0974-360X.2024.00099   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-2-27


REFERENCES:
1.    Qian W, Liu W, Zhu D, et al. Natural skin‑whitening compounds for the treatment of melanogenesis (Review). Exp Ther Med.2020; 20: 173–185.
2.    D’Mello SAN, Finlay GJ, Baguley BC, et al. Signaling pathways in melanogenesis. Int J Mol Sci. 2016; 17: 1–18.
3.    Goswami-Giri A. Qualitative and Quantitative analysis of Dopa from Solanum melangena. Asian J Res Chem. 2014; 7: 954–963.
4.    Hossain MR, Ansary TM, Komine M, et al. Diversified stimuli‐induced inflammatory pathways cause skin pigmentation. Int J Mol Sci. 2021; 22.. DOI: 10.3390/ijms22083970.
5.    Videira IF dos S, Moura DFL, Magina S. Mechanisms regulating melanogenesis. An Bras Dermatol. 2013; 88: 76–83.
6.    Ozbey R, Okur MI. The use of 4% hydroquinone, 0.1% tretinoin, and 0.1% betamethasone creams to prevent hyperpigmentation of split-thickness skin grafts in Long-Evans rats. J Cosmet Dermatol. 2020; 19: 2663–2668.
7.    Nijhawan RI, Alexis AF. Practical approaches to medical and cosmetic dermatology in skin of color patients. Expert Rev Dermatol. 2011; 6: 175–187.
8.    Tan LF, Mogana R, Chinnappan S, et al. Various Plants and Bioactive Constituents for Pigmentation Control: A Review. Res J Pharm Technol. 2021; 14: 6106–6112.
9.    Goswami-Giri AS. Immobilized onion leaves tyrosinase on agar- Abelmoschus esculentus. Asian J Res Chem 2012; 5: 664–668.
10.    Duraisamy A, Narayanaswamy N, Balakrishnan K. Antioxidant and Anti-Tyrosinase Activity of Some Medicinal Plants. Res J Pharmacogn Phytochem. 2011; 3: 86–90.
11.    Muchtaridi M, Luthfika Dewi M. The recent update of deoxyarbutin: A skin depigmentation agent with tyrosinase inhibition targeting. Int J Appl Pharm. 2020; 12: 1–7.
12.    Phasha V, Senabe J, Ndzotoyi P, et al. Review on the Use of Kojic Acid—A Skin-Lightening Ingredient. Cosmetics. 2022; 9: 1–11.
13.    Gurale V V, D PM. Evaluation of Antioxidant and Tyrosinase Inhibitory Activity of Punica granatum Flower Extract. Res J Pharmacogn Phytochem. 2012; 4: 267–270.
14.    Kiattisin K, Nantarat T, Leelapornpisid P. Evaluation of antioxidant and anti-tyrosinase activities as well as stability of green and roasted coffee bean extracts from Coffea arabica and Coffea canephora grown in Thailand. J Pharmacogn Phyther. 2016; 8: 182–192.
15.    Migas P, Krauze-Baranowska M. The significance of arbutin and its derivatives in therapy and cosmetics. Phytochem Lett. 2015; 13: 35–40.
16.    Burnett CL, Bergfeld WF, Belsito D V., et al. Final report of the safety assessment of kojic acid as used in cosmetics. Int J Toxicol; 29. Epub ahead of print 2010. DOI: 10.1177/1091581810385956.
17.    Patel A. Postinflammatory hyperpigmentation: Review of pathogenesis, prevention, and treatment. Pigment Int 2014; 1: 59.
18.    Purwanto EH, Rubiyo, Towaha J. Karakteristik Mutu dan Citarasa Kopi Robusta Klon BP 42, BP 358 dan BP 308 Asal Bali dan Lampung. Sirinov, Balai Penelit Tanam Ind dan Penyegar. 2015; 3: 67–74.
19.    Elfiah U, Perdanakusuma DS, Saputro ID, et al. Robusta BP-42 coffee bean extract is a new anti-tyrosinase candidate to reduce melanogenesis activity. Bali Med J. 2022; 11: 2022–2026.
20.    Sari DS, Sakinah N, Nuri, et al. Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering. Res J Pharm Technol. 2022; 15: 5005–5010.
21.    Deepthi BVP, Muthuprasanna P. Effect of Surfactant on Extraction of Caffeine from Coffee Powder. Res J Pharmacogn Phytochem. 2012; 4: 271–276.
22.    Roy A, Das B. Effects of caffeine on health: A review. Res J Pharm Technol 2015; 8: 1312–1319.
23.    Herman A, Herman AP. Caffeine’s Mechanisms of Action and Its Cosmetic Use. Skin Pharmacol Physiol. 2013; 26: 8–14.
24.    Ribeiro AS, Estanqueiro M, Oliveira MB, et al. Main benefits and applicability of plant extracts in skin care products. Cosmetics. 2015; 2: 48–65.
25.    Oakley A. Topical formulations, https://dermnetnz.org/topics/topical-formulations# (2016, accessed 4 March 2023).
26.    Buhse L, Kolinski R, Westenberger B, et al. Topical drug classification. Int J Pharm. 2005; 295: 101–112.
27.    Prabowo WH, Awal Prasetyo, Neni Susilaningsih. The Effect of Multilevel Doses of Caffeine on Tissue Macrophage and Blood Lymphocyte Count in Autologous Full Thickness Skin Graft Healing in Sprague Dawley Rats. Biosci Med  J Biomed Transl Res; 6. Epub ahead of print 9 March 2022. DOI: 10.37275/bsm.v6i5.498.
28.    Charles-Bernard M, Kraehenbuehl K, Rytz A, et al. Interactions between volatile and nonvolatile coffee components. 1. Screening of nonvolatile components. J Agric Food Chem. 2005; 53: 4417–4425.
29.    Dong W, Tan L, Zhao J, et al. Characterization of fatty acid, amino acid and volatile compound compositions and bioactive components of seven coffee (Coffea robusta) cultivars grown in Hainan Province, China. Molecules 2015; 20: 16687–16708.
30.    Shivhare SC, Malviya KG, Malviya KKS, et al. A Review : Natural Skin Lighting and Nourishing Agents. Res J Top Cosmet Sci. 2012; 3: 11–15.
31.    Yudantara IMA, Cahyani NKN, Saputra MAW, et al. Chlorogenic acid and kojic acid as anti-hyperpigmentation: in silico study. Pharm Reports. 2022; 1: 23.
32.    Vijayakumar V, Radhakrishnan N, Vasantha-Srinivasan P. Molecular docking analysis of triazole analogues as inhibitors of human neutrophil elastase (HNE), matrix metalloproteinase (MMP 2 and MMP 9) and tyrosinase. Res J Pharm Technol. 2020; 13: 2777–2783.
33.    Xu J-G, Hu Q-P, Liu Y. Antioxidant and DNA-Protective Activities of Chlorogenic Acid Isomers. J Agric Food Chem. 2012; 60: 11625–11630.
34.    Lin YL, Chang YY, Yang DJ, et al. Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters. Food Chem. 2013; 140: 31–38.
35.    Stamatas GN, Zmudzka BZ, Kollias N, et al. Non-invasive measurements of skin pigmentation in situ. Pigment Cell Res. 2004; 17: 618–626.
36.    Yamate Y, Hiramoto K, Sato EF. The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice. Skin Pharmacol Physiol. 2017; 30: 24–35.
37.    Huang HC, Wei CM, Siao JH, et al. Supercritical Fluid Extract of Spent Coffee Grounds Attenuates Melanogenesis through Downregulation of the PKA, PI3K/Akt, and MAPK Signaling Pathways. Evidence-based Complement Altern Med. 2016; 2016: 1–11.
38.    Ky CL, Louarn J, Dussert S, et al. Caffeine, trigonelline, chlorogenic acids and sucrose diversity in wild Coffea arabica L. and C. canephora P. accessions. Food Chem. 2001; 75: 223–230.
39.    Eun Lee K, Bharadwaj S, Yadava U, et al. Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach. J Enzyme Inhib Med Chem. 2019; 34: 927–936.
40.    Ren Y, Wang C, Xu J, et al. Cafestol and kahweol: A review on their bioactivities and pharmacological properties. Int J Mol Sci. 20. Epub ahead of print 2019. DOI: 10.3390/ijms20174238.
41.    Mohamadi N, Sharififar F, Pournamdari M, et al. A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid. J Diet Suppl. 2018; 15: 207–222.
42.    Fu C, Chen J, Lu J, et al. Roles of inflammation factors in melanogenesis (Review). Mol Med Rep. 2020; 21: 1421–1430.
43.    Funakoshi-Tago M, Matsutaka M, Hokimoto S, et al. Coffee ingredients, hydroquinone, pyrocatechol, and 4-ethylcatechol exhibit anti-inflammatory activity through inhibiting NF-κB and activating Nrf2. J Funct Foods. 2022; 90: 104980.

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