Author(s): Nurul Aqmar Mohamad Nor Hazalin, Hasseri Halim, Izzah Firzana Rosli, Nur Aqilah Nazri, Hannis Fadzillah Mohsin, Rozaini Mohd Zohdi, Donna Maretta Ariestanti, Richard Johari James

Email(s): richard@uitm.edu.my

DOI: 10.52711/0974-360X.2024.00091   

Address: Nurul Aqmar Mohamad Nor Hazalin1,2, Hasseri Halim1,2, Izzah Firzana Rosli2, Nur Aqilah Nazri2, Hannis Fadzillah Mohsin2, Rozaini Mohd Zohdi2,3, Donna Maretta Ariestanti4, Richard Johari James1,2*
1Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
2Faculty of Pharmacy, Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
3Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA Selangor Branch, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
4Faculty of Pharmacy, University of Indonesia, Depok 16424, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
Phaleria macrocarpais one of the commonly usedplants in East Asia as herbal medicines. The extract of Phaleria macrocarpa can exhibit a variety of beneficial pharmacological activities, including anti-diabetic, and antioxidant activities which are primarily contributed by the constituents isolated from different parts of Phaleria macrocarpa. However, there have been only limited attempts to explore the antioxidant properties of this plant in relation to its medicinal use. Therefore, this study was conducted to determine the antioxidant activity and protective effect of P. macrocarpa methanolic fruit (PMFM) extract against oxidative stress in brine shrimp (Artemia salina). The antioxidant activity of PMFM extractwas evaluated using 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) assays.In vitro brine shrimp toxicity assay was performed on nauplii of Artemia salina to determine the toxicity and the protective effects of the PMFM extract. The DPPH and FRAP assays results showed that PMFM extracthas good antioxidant activity.Additionally, treatment with PMFM extract (concentration ranging from 0.05 to 0.2 mg/ml) was able to protect Artemia salinanauplii from the toxic effects of hydrogen peroxide.Thus, the present findings demonstrate that PMFM extractpossesses good antioxidant and protective activity against oxidative stress.


Cite this article:
Nurul Aqmar Mohamad Nor Hazalin, Hasseri Halim, Izzah Firzana Rosli, Nur Aqilah Nazri, Hannis Fadzillah Mohsin, Rozaini Mohd Zohdi, Donna Maretta Ariestanti, Richard Johari James. Protective effect of Phaleria macrocarpa Methanolic Fruit Extract against Oxidative Stress in Brine Shrimps. Research Journal of Pharmacy and Technology. 2024; 17(2):585-0. doi: 10.52711/0974-360X.2024.00091

Cite(Electronic):
Nurul Aqmar Mohamad Nor Hazalin, Hasseri Halim, Izzah Firzana Rosli, Nur Aqilah Nazri, Hannis Fadzillah Mohsin, Rozaini Mohd Zohdi, Donna Maretta Ariestanti, Richard Johari James. Protective effect of Phaleria macrocarpa Methanolic Fruit Extract against Oxidative Stress in Brine Shrimps. Research Journal of Pharmacy and Technology. 2024; 17(2):585-0. doi: 10.52711/0974-360X.2024.00091   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-2-19


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