Author(s):
Baby Prabowo, Ani Melani Maskoen, Arief Budiarto, EM Setiawatie, Komara Ira, Yazid Harmaz, Eriska Riyanti, Irmaleny Irmaleny, Sumantri suryana, Arif Rachman
Email(s):
arif.rachman@idu.ac.id
DOI:
10.52711/0974-360X.2024.00872 
Address:
Baby Prabowo1, Ani Melani Maskoen2,3, Arief Budiarto4, EM Setiawatie5, Komara Ira6,Yazid Harmaz7, Eriska Riyanti8, Irmaleny Irmaleny9, Sumantri suryana10, Arif Rachman11,12*
1Doctoral Degree Study Program in Military Dentistry Science, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
2Department of Oral Biology, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
3Molecular Genetic Laboratory, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
4Faculty of Psychology, Jenderal Achmad Yani University, Cimahi, Indonesia.
5Department of Periodontia, Faculty of Dentistry, Airlangga University, Surabaya, Indonesia.
6Department of Periodontia, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
7Oral Surgery Study Program, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
8Department of Pediatric Dentistry, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
9Department of Conservative, F
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Periodontitis disorders can result in disease Periodontitis is a chronic, destructive, and irreversible inflammatory disease. Stress is a direct cause of periodontal problems which is connected through neuro-immunoendocrinological mechanisms. It can be caused by many things, the discrepancy between expectations and reality, physical pressure, psychological pressure, and others. Stress can cause changes in interleukin expression, hormone expression, protein expression, and the number of PMNs and macrophages. This study used Wistar rats with two treatment groups and one control group with the following conditions: male type, weight 300grams, age 5 months. Each treatment group was exhausted (treadmill) for 15 minutes and rested for 45 minutes and the treatment group was afraid (cats as predators of mice). Statistically, the role of IL-1ß, IL-6, IL-10, Ig G, Ig A, PMN, Macrophage, and Cortisol has an effect on periodontitis Overall examination showed that the description of the effect of psychological stress on periodontal disorders in Wistar rats. The highest IL-1ß expression on the first day of running (L1) and the predator treatment (P1) on the first day also showed a high value, the role of IL-1ß as the main biomarker of the effects of chronic stress. is by increasing IL-1ß converting these inflammatory signals into nerve signals and with the endocrine system (melatonin and cortisol) to compensate. In conclusion, the Widening of the periodontal tissue under stress conditions as a marker of periodontal disorders in Wistar rats shows the main role of all variables in the mechanism of psychological stress in periodontal disorders.
Cite this article:
Baby Prabowo, Ani Melani Maskoen, Arief Budiarto, EM Setiawatie, Komara Ira,Yazid Harmaz, Eriska Riyanti, Irmaleny Irmaleny, Sumantri suryana, Arif Rachman. Role of IL-1β, IL-6, IL-10, IgG, IgA, PMN, Macrophage, and Cortisol on Psychological Stress Mechanisms in Periodontal Disorders. Research Journal Pharmacy and Technology. 2024;17(12):5729-7. doi: 10.52711/0974-360X.2024.00872
Cite(Electronic):
Baby Prabowo, Ani Melani Maskoen, Arief Budiarto, EM Setiawatie, Komara Ira,Yazid Harmaz, Eriska Riyanti, Irmaleny Irmaleny, Sumantri suryana, Arif Rachman. Role of IL-1β, IL-6, IL-10, IgG, IgA, PMN, Macrophage, and Cortisol on Psychological Stress Mechanisms in Periodontal Disorders. Research Journal Pharmacy and Technology. 2024;17(12):5729-7. doi: 10.52711/0974-360X.2024.00872 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-9
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