Author(s): Sabeerali Ansarali, Ganapathy Murugan Alagu Lakshmanan, Selvarasuvasuki Manikandan, Shagufta Rashid

Email(s): gmalakshmanan@gmail.com

DOI: 10.52711/0974-360X.2024.00871   

Address: Sabeerali Ansarali1, Ganapathy Murugan Alagu Lakshmanan2*, Selvarasuvasuki Manikandan3, Shagufta Rashid4
1Assistant Professor, PG Department of Botany, Sri Vidya Mandir Arts and Science College, Uthangarai 636 902, Krishnagiri, Tamil Nadu, India.
2Department of Botany, Thiru Kolanjiappar Government Arts College, Vridhachalam - 606001, Tamil Nadu, India.
3Guest Lecturer in Botany, Government Arts and Science College, Thittakudi - 606106, Tamil Nadu, India.
4Department of Botany, Annamalai University, Annamalai Nagar - 608002, Chidambaram, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 12,     Year - 2024


ABSTRACT:
Bone fractures are a prevalent orthopaedic issue that many people experience. While the body can naturally repair a broken bone, the duration of the healing process can range from weeks to years, depending on the injury's severity and potential complications. Different techniques are used in the process of bone healing, including both experimental and computational modeling methods. Computational modeling and simulation have been used to address the limitations of experimental methods. This study focuses on screening and investigating bone healing compounds found in the leaves of Cissus rotundifolia and the stem of Cissus quadrangularis (round-stemmed variant) using molecular docking studies to identify potent compounds for bone healing treatment. GC-MS analysis revealed two active compounds: alpha-methylglucofuranoside and tetradecanoic acid. These compounds were tested against the bone healing protein ABMP2 (ID: 4MID) sourced from the Protein Data Bank (PDB) and showed good docking scores and reasonable stability. In vivo and in-vitro approaches are recommended to further elucidate the molecular mechanisms of these compounds and develop them into potent drugs for treating bone fractures. The present study clearly observed with the screened compounds could possibly develop into potent drugs for treating bone fractures.


Cite this article:
Sabeerali Ansarali, Ganapathy Murugan Alagu Lakshmanan, Selvarasuvasuki Manikandan, Shagufta Rashid. Virtual Screening Studies on Bone Healing Phytochemicals Isolated from Cissus quadrangularis (round variant) and Cissus rotundifolia. Research Journal Pharmacy and Technology. 2024;17(12):5724-8. doi: 10.52711/0974-360X.2024.00871

Cite(Electronic):
Sabeerali Ansarali, Ganapathy Murugan Alagu Lakshmanan, Selvarasuvasuki Manikandan, Shagufta Rashid. Virtual Screening Studies on Bone Healing Phytochemicals Isolated from Cissus quadrangularis (round variant) and Cissus rotundifolia. Research Journal Pharmacy and Technology. 2024;17(12):5724-8. doi: 10.52711/0974-360X.2024.00871   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-8


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