Author(s):
Sadia Afrin, Jai Shanker Pillai HP, Challaraj Emmanuel E S, Patrik Viktor, Md. Al Hafiz, Raed Fanoukh Aboqade Al-Aouadi, Rezwan Ahmed Mahedi, Mustafa mudhafar, H.S. Batra, Suresh Babu Kondaveeti, Nikolaos Syrmos, Mohammad Chand Jamali, Abdul Kareem J. Al-Azzawi, Calvin R. Wei, Mohammad Mahfuz Enam Elahi
Email(s):
pharmacist.rezwan@gmail.com , mjamali68@gmail.com
DOI:
10.52711/0974-360X.2024.00934 
Address:
Sadia Afrin1, Jai Shanker Pillai HP2, Challaraj Emmanuel E S3, Patrik Viktor4, Md. Al Hafiz5, Raed Fanoukh Aboqade Al-Aouadi6, Rezwan Ahmed Mahedi1,7*, Mustafa mudhafar8, H.S. Batra9, Suresh Babu Kondaveeti10, Nikolaos Syrmos11, Mohammad Chand Jamali12, Abdul Kareem J. Al-Azzawi13, Calvin R. Wei14, Mohammad Mahfuz Enam Elahi15
1Department of Pharmacy, Comilla university, Cumilla, Bangladesh.
2Department of Medical Laboratory Science, Komar University of Science and Technology, Sulaimaniyah, Kurdistan Region, Iraq.
3Department of Life Sciences, Kristu Jayanti College (Autonomous), Bengaluru, Karnataka, India.
4 Óbuda University, Keleti Károly Faculty of Business and Management, Óbuda University, Tavaszmezo u. 15-17, H-1084 Budapest, Hungary.
5Department of pharmacy, East West University, Aftabnagar Dhaka-1212, Bangladesh.
6College of Medicine, Al-Ayen Iraqi University, Thi-Qar, Iraq.
7Research Secretary, Bangladesh Pharmacists’ Forum (Comilla University), Bangladesh.
8De
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Drug development is both a task and a promise for fighting illnesses and improving health. Innovative treatments for cancer, infectious diseases, chronic illnesses, and uncommon genetic abnormalities have long been difficult and resource-intensive to develop. In the 21st century, bioinformatics has become a pioneering and essential technique for drug development. Bioinformatics uses computational algorithms, statistical analysis, and data-driven insights to understand life's core biological processes. Bioinformatics helps drug discovery researchers understand illness biological mechanisms, identify therapeutic targets, screen candidate molecules, and improve drug development pipelines. Drug development has been defined by fortuitous discoveries and tedious laboratory work, requiring years or decades to get a possible therapeutic agent to the patient bedside. Bioinformatics has transformed drug development in biomedicine today. This comprehensive study examines how bioinformatics has changed medication development. We want to study and analyse bioinformatics' many uses. We discover the complex network of genomes, proteomics, structural biology, and computational modelling that underscores bioinformatics' vital significance as we investigate this dynamic subject. This review illuminates the difficult balance between biological knowledge and computational capabilities to produce innovative treatments. The systematic review uses a thorough literature search, study selection criteria, and data extraction. Genomic target identification, virtual screening, pharmacophore modelling, pathway analysis, and toxicity prediction are among the bioinformatics applications in drug development we find and classify. These examples demonstrate bioinformatics' ability to accelerate medication development. The systematic review covers bioinformatics' drug discovery applications and shows how this diverse discipline is changing pharmaceutical research. It shows how to improve medication development, reduce side effects, and achieve precision medicine. The combination of bioinformatics and drug development offers optimism for easing human suffering, extending lifespans, and fighting a broad range of illnesses.
Cite this article:
Sadia Afrin, Jai Shanker Pillai HP, Challaraj Emmanuel E S, Patrik Viktor, Md. Al Hafiz, Raed Fanoukh Aboqade Al-Aouadi, Rezwan Ahmed Mahedi, Mustafa mudhafar, H.S. Batra, Suresh Babu Kondaveeti, Nikolaos Syrmos, Mohammad Chand Jamali, Abdul Kareem J. Al-Azzawi, Calvin R. Wei, Mohammad Mahfuz Enam Elahi. A Systematic Review of Bioinformatics' Influence on Drug Developments. Research Journal Pharmacy and Technology. 2024;17(12):6158-4. doi: 10.52711/0974-360X.2024.00934
Cite(Electronic):
Sadia Afrin, Jai Shanker Pillai HP, Challaraj Emmanuel E S, Patrik Viktor, Md. Al Hafiz, Raed Fanoukh Aboqade Al-Aouadi, Rezwan Ahmed Mahedi, Mustafa mudhafar, H.S. Batra, Suresh Babu Kondaveeti, Nikolaos Syrmos, Mohammad Chand Jamali, Abdul Kareem J. Al-Azzawi, Calvin R. Wei, Mohammad Mahfuz Enam Elahi. A Systematic Review of Bioinformatics' Influence on Drug Developments. Research Journal Pharmacy and Technology. 2024;17(12):6158-4. doi: 10.52711/0974-360X.2024.00934 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-71
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