ABSTRACT:
Background: Rheumatoid arthritis is disease of concern in today’s population, due to their lifestyle, smoking, stress, obesity. As herbal drugs have lesser side effects, and chilli and honey are being used by global population from generations. But as chilli alone could cause burning sensation, very hard to swallow, and excessive use could cause gastric ulceration, but in combination with honey, the burning sensation caused by chilli and honey have healing properties too. Methods: Anti-inflammatory activity of capsaicin was evaluated in Arthritis induced rat models. Result: The reduction in inflammation, Plethysmometer was used to measure inflammation every week, and it showed decline in inflammation, with declining in body weight too. The group of animals where administered dose was hydro-alcoholic extract at 60 mg/ kg with honey after 28 days show no symptoms of arthritis, whereas other groups showed low to mild arthritis but their level of inflammation was very low as compared to positive disease group. Conclusion: At last, it has been concluded that Capsaicin extract if given in combination with honey shows better anti-inflammatory results. But in combination with honey there is better reduction in inflammation due to cytoprotective and wound healing properties.