Author(s):
Dewi Sinta Megawati, Juni Ekowati, Siswandono Siswodihardjo, A. Ghanaim Fasya
Email(s):
juni-e@ff.unair.ac.id
DOI:
10.52711/0974-360X.2024.00919 
Address:
Dewi Sinta Megawati1,2, Juni Ekowati3,4*, Siswandono Siswodihardjo3,4,5, A. Ghanaim Fasya6
1Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya-60115, (East Java) Indonesia.
2Department of Pharmacy, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang-65144, (East Java) Indonesia.
3Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya-60115, (East Java) Indonesia.
4Drug Development Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya-60115, (East Java) Indonesia.
5Faculty of Pharmacy, Bhakti Wiyata Institute of Health Sciences, Kediri-64114, (East Java) Indonesia.
6Department of Chemistry, Faculty of Science and Technology, Maulana Malik Ibrahim State Islamic University, Malang-65144, (East Java) Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Oxidative stress occurs when the body accumulates reactive oxygen species (ROS), which can be generated through enzymatic reactions or when oxygen interacts with cellular molecules. Antioxidants are frequently employed to impede, postpone, or minimize oxidative stress within the human body. These antioxidants supply electrons to free radicals, thereby counterbalancing their harmful effects. Compounds containing thiourea groups have attracted attention due to their diverse pharmaceutical properties, including their roles as antioxidants. This study aims to determine the antioxidant potential of the N-benzoyl-N’-naphthylthiourea (BNTU) and its four derivatives. This research evaluates the antioxidant activity of BNTU and its derivatives using the scavenging method of DPPH radicals. A docking study revealed potential interactions between binding models (human ROS1 kinase, PDB ID 3ZBF) and the antioxidant properties of the target compounds. Based on the results of the DPPH test, it was found that the antioxidant activity (IC50) for 4CFBNTU was recorded at 189.6 ppm, whereas 3CFBNTU showed a measurement of 294.5 ppm. Conversely, BNTU, 4TBBNTU, and 4OCBNTU displayed IC50 values surpassing 400 ppm. As for the Antioxidant Activity Index (AAI), The BNTU and its derivatives have AAI values < 0.56. The docking results obtained are consistent with the conclusions drawn from the antioxidant investigation. The four derivatives of BNTU have better antioxidant activity than the lead compound. Among them, 4CFBNTU exhibits the best antioxidant activity, although its antioxidant properties are relatively weak.
Cite this article:
Dewi Sinta Megawati, Juni Ekowati, Siswandono Siswodihardjo, A. Ghanaim Fasya. Antioxidant Activities and Molecular Docking of N-benzoyl-N’-naphthylthiourea Derivatives. Research Journal Pharmacy and Technology. 2024;17(12):6063-9. doi: 10.52711/0974-360X.2024.00919
Cite(Electronic):
Dewi Sinta Megawati, Juni Ekowati, Siswandono Siswodihardjo, A. Ghanaim Fasya. Antioxidant Activities and Molecular Docking of N-benzoyl-N’-naphthylthiourea Derivatives. Research Journal Pharmacy and Technology. 2024;17(12):6063-9. doi: 10.52711/0974-360X.2024.00919 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-56
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