Author(s): Mukthinuthalapati Mathrusri Annapurna, Pappala Heshitha

Email(s): mmukthin@gitam.edu

DOI: 10.52711/0974-360X.2024.00908   

Address: Mukthinuthalapati Mathrusri Annapurna*, Pappala Heshitha
GITAM School of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India-530045.
*Corresponding Author

Published In:   Volume - 17,      Issue - 12,     Year - 2024


ABSTRACT:
Loratadine is a second-generation antihistamine that is used to treat allergic rhinitis and hives. New spectrophotometric techniques have been proposed for the estimation of Loratadine in pharmaceutical dosage forms. A double-beam SHIMADZU Model UV-1800UV-VIS spectrophotometer was used for the present study. Loratadine has shown linearity over the concentration range 0.5-50 µg/mL in borate buffer (pH 9.0), phosphate buffer (pH 5.8), phosphate buffer (pH 7.8), and distilled water, and the methods were validated as per ICH guidelines. The proposed methods are simple, and economical and can be successfully applied for the assay of Loratadine in pharmaceutical dosage forms.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Pappala Heshitha. New spectrophotometric methods for the determination of Loratadine. Research Journal Pharmacy and Technology. 2024;17(12):5984-0. doi: 10.52711/0974-360X.2024.00908

Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Pappala Heshitha. New spectrophotometric methods for the determination of Loratadine. Research Journal Pharmacy and Technology. 2024;17(12):5984-0. doi: 10.52711/0974-360X.2024.00908   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-45


REFERENCES:
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2.    Noor Jahan et al., Spectrophotometric determination of Loratadine in bulk and pharmaceutical dosage form. International Journal of Pharma Sciences and Research. 2018; 9(5): 65-73.
3.    Georgeta Pavalachea et al., Determination of Loratadine in pharmaceuticals by a spectrophotometric method. Ovidius University Annals of Chemistry. 2015; 26(1): 27-31.
4.    Prathap B et al., Analytical method development and validation for the estimation of Loratadine using UV spectrophotometer. World Journal of Pharmaceutical Research. 2023; 12(6): 701-714.
5.    Heshitha P and Mathrusri Annapurna M. A review on analytical techniques for the assay of Loratadine. Acta Scientific Pharmaceutical Sciences. 2023; 7(12): 59-62.
6.    International Conference on Harmonization, Q2A: Text on Validation of Analytical Procedures. 2005.


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