Author(s):
Anitha Roy, Preetha S
Email(s):
drpreeth.homeo@gmail.com
DOI:
10.52711/0974-360X.2024.00907 
Address:
Anitha Roy1, Preetha S2*
1Professor, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 77, Tamil Nadu, India.
2Assistant Professor, Department of Physiology, Sri Lalithambigai Medical College and Hospitals, Dr. M.G.R. Educational and Research Institute, Service Rd, Maduravoyal, Adayalampattu, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Herbal medications are used to treat diseases and conditions with fewer adverse effects, ease of availability and low cost. So many bioactive compounds were identified from the plant, Andrographis paniculata . The objective of this study was to determine the molecular interactions of selected compounds with diabetes mellitus (DM) target protein Glucokinase. In this work, the screening of the best molecules as bioactive compounds is accomplished by a molecular docking study with chosen DM target protein. In this study, five possible bioactive compounds such as Andrographolide, 3,14,19-triacetylandrographolide, 14-deoxyandrographolide, Andrograpanin and Neoandrographolide have been successfully identified by binding energy as the most effective ligands for the management of diabetes mellitus.
Cite this article:
Anitha Roy, Preetha S. Exploration of Potent Compounds with Glucokinase Activity for Diabetes Through Molecular Docking Analysis. Research Journal Pharmacy and Technology. 2024;17(12):5981-3. doi: 10.52711/0974-360X.2024.00907
Cite(Electronic):
Anitha Roy, Preetha S. Exploration of Potent Compounds with Glucokinase Activity for Diabetes Through Molecular Docking Analysis. Research Journal Pharmacy and Technology. 2024;17(12):5981-3. doi: 10.52711/0974-360X.2024.00907 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-44
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