Author(s):
Simran C. Chaudhary, Pallavi A. Patil, Hennu Dhar, Udaykumar S. Patil, Abhijit L. Patil4, Vaibhavi N. Garge
Email(s):
sbvp2023@gmail.com
DOI:
10.52711/0974-360X.2024.00905 
Address:
Simran C. Chaudhary1, Pallavi A. Patil1*, Hennu Dhar2, Udaykumar S. Patil3, Abhijit L. Patil4, Vaibhavi N. Garge1
1Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, C.B.D. Belapur, Navi Mumbai, 400614.
2Department of Pharmacology, FMHS Sgt University, Haryana, 122505.
3Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, Kolhapur, 416013.
4Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, 416112.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Objective: To understand the cardioprotective effect of Moringa oleifera (MO) seed powder using isoproterenol induced cardiotoxicity in albino rats of wistar strain. Materials and Methods: Hydroalcoholic extract of MO (HAMO) seeds was prepared by soxhlet method and used for the study. After phytochemical analysis, the extract was evaluated for in vivo study. Six rats were grouped. Group 1 as vehicle, group 2 as disease control, group 3 as standard, group 4 and 5 as low and high dose of hydroalcoholic extract of MO (200mg/kg, 400mg/kg) respectively. ECG parameters, cardiac markers and oxidative stress were assessed. Results: 4% yield was obtained. ST segment elevation and increased heart rate by Isoproterenol was treated by hydroalcoholic extract of MO seeds. CK-MB, LDH levels were also restored in treatment groups as compared to disease control. The endogenous antioxidant enzymes catalase and GSH activity increased in treatment groups whereas lipid peroxidation was decreased significantly. The HAMO (400mg/kg) showed better cardioprotective activity as equivalent to Terminalia arjuna tablets which was used as standard. In histology findings, HAMO (400mg/kg) showed decrease in necrosis as compared to disease control. Conclusion: The HAMO (400mg/kg) has proven to attenuate cardiotoxicity induced by Isoproterenol, confirmed by ECG, cardiac markers and histopathological findings.
Cite this article:
Simran C. Chaudhary, Pallavi A. Patil, Hennu Dhar, Udaykumar S. Patil, Abhijit L. Patil4, Vaibhavi N. Garge. Attenuation of Isoproterenol Induced Cardiotoxicity by Moringa oleifera Seeds. Research Journal Pharmacy and Technology. 2024;17(12):5967-3. doi: 10.52711/0974-360X.2024.00905
Cite(Electronic):
Simran C. Chaudhary, Pallavi A. Patil, Hennu Dhar, Udaykumar S. Patil, Abhijit L. Patil4, Vaibhavi N. Garge. Attenuation of Isoproterenol Induced Cardiotoxicity by Moringa oleifera Seeds. Research Journal Pharmacy and Technology. 2024;17(12):5967-3. doi: 10.52711/0974-360X.2024.00905 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-42
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