Author(s):
Meilinda Mustika, Boy Chandra, Sestry Misfadhila, Muhammad Haris, Dinda P Sari, Muhammad S Mustaqim, Anisa M Utami
Email(s):
meipiai146@stifarm-padang.ac.id
DOI:
10.52711/0974-360X.2024.00902 
Address:
Meilinda Mustika*, Boy Chandra, Sestry Misfadhila, Muhammad Haris, Dinda P Sari, Muhammad S Mustaqim, Anisa M Utami
Department of Pharmaceutical Chemistry, School of Pharmaceutical Science Padang, West Sumatra, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
One of the important benefits of fig leaves is their ability as a natural antioxidant. However, further research is needed to comprehensively assess the antioxidant potential of fig leaf extract. The present research aimed to examine the antioxidant activity of ethanol extract and the fraction of five varieties of Ficus carica leaves grown in West Sumatra Indonesia; Panache Tiger (PT), Red Palestine (RP), Green Jordan (GJ), LSU Gold (LG), and Bajihong (BJ). The extraction process uses the Ultrasound-assisted extraction method and the fractionation process uses a separating funnel. Sample solutions were prepared in five concentrations: 4, 8, 12, 16, and 20 µg/ml. Antioxidant testing was carried out using the DPPH (2,2 diphenyl-1-picrylhydrazyl). UV-Vis double beam spectrophotometry measured the absorbance in each sample solution. The IC50 values of ethanol extract F. carica leaves PT, RP, GJ, LG, and BJ varieties were 19.4132; 19.0150; 17.5623; 19.7136; 22.8838 µg/mL, hexane fraction were 84.6393; 84.5263; 83.8990; 85.3026; 87.7560 µg/mL, ethyl acetate fraction were 20.3750; 18.7451; 18,1990; 22.5833; 27.8047 µg/ml and water fraction were 19.7137; 18.2529; 15.9352; 20.6544; 22.9029 µg/ml. The antioxidant activity of the five varieties of F. carica in this study in hydro-alcoholic fraction, ethanol extract, and ethyl acetate fraction was classified into a very strong category, while the hexane fraction was in a strong category. It can be concluded that the F. carica leaves in this study have the potential as antioxidants whereas the Green Jordan variety in hydro-alcoholic fraction has a higher.
Cite this article:
Meilinda Mustika, Boy Chandra, Sestry Misfadhila, Muhammad Haris, Dinda P Sari, Muhammad S Mustaqim, Anisa M Utami. Evaluation of natural antioxidants from different varieties of Ficus carica leaves grown in west Sumatera Indonesia. Research Journal Pharmacy and Technology. 2024;17(12):5949-4. doi: 10.52711/0974-360X.2024.00902
Cite(Electronic):
Meilinda Mustika, Boy Chandra, Sestry Misfadhila, Muhammad Haris, Dinda P Sari, Muhammad S Mustaqim, Anisa M Utami. Evaluation of natural antioxidants from different varieties of Ficus carica leaves grown in west Sumatera Indonesia. Research Journal Pharmacy and Technology. 2024;17(12):5949-4. doi: 10.52711/0974-360X.2024.00902 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-39
REFERENCES:
1. IQAir. Rangking Indelks Kualitas Udara Dunia | IQAir [Intelrnelt]. Iqair.Com. 2023. Availablel from: https://www.iqair.com/id/world-air-quality-ranking
2. Unsal V, Cicelk M, Sabancilar İ. Toxicity of carbon teltrachloridel, frelel radicals and rolel of antioxidants. Relv ELnviron Helalth. 2021; 36(2): 279–95.
3. Jadhav Samelelr S., Salunkhel Vijay R. MCS. Daily Consumption of Antioxidants:-Prelvelntion of Diselasel is belttelr than Curel. Asian J Pharm Res. 2013; 3(1): 33–9.
4. R. Manikandan AVA. A Relvielw on Antioxidant activity of Psidium guajava. Rels J Pharm Telch. 2015; 8(3): 339–42.
5. Çalişkan O, Aytelkin Polat A. Phytochelmical and antioxidant propelrtiels of sellelcteld fig (Ficus carica L.) accelssions from thel elastelrn Melditelrranelan relgion of Turkely. Sci Hortic (Amstelrdam). 2011; 128(4): 473–8.
6. Harzallah A, Bhouri AM, Amri Z, Soltana H, Hammami M. Phytochelmical contelnt and antioxidant activity of diffelrelnt fruit parts juicels of threlel figs (Ficus carica L.) varieltiels grown in Tunisia. Ind Crops Prod [Intelrnelt]. 2016; 83: 255–67. Availablel from: http://dx.doi.org/10.1016/j.indcrop.2015.12.043
7. Wojdyło A, Nowicka P, Carbonelll-Barrachina ÁA, Helrnándelz F. Phelnolic compounds, antioxidant and antidiabeltic activity of diffelrelnt cultivars of Ficus carica L. fruits. J Funct Foods [Intelrnelt]. 2016; 25: 421–32. Availablel from: http://dx.doi.org/10.1016/j.jff.2016.06.015
8. Belrtram GC. Thel statel of food and agriculturel, 1966. Vol. 59, Thel ELugelnics relvielw. 1967. 73–74 p.
9. Welli AM, Al-Blushi AAM, Hossain MA. ELvaluation of antioxidant and antimicrobial potelntial of diffelrelnt lelavels crudel elxtracts of Omani Ficus carica against food bornel pathogelnic bactelria. Asian Pacific J Trop Dis. 2015;5(1):13–6.
10. Barolo MI, Ruiz Mostacelro N, Lópelz SN. Ficus carica L. (Moracelael): An ancielnt sourcel of food and helalth. Food Chelm [Intelrnelt]. 2014; 164(April): 119–27. Availablel from: http://dx.doi.org/10.1016/j.foodchelm.2014.04.112
11. Mamoucha S, Fokialakis N, Christodoulakis NS. Lelaf structurel and histochelmistry of Ficus carica (Moracelael), thel fig trelel. Flora Morphol Distrib Funct ELcol Plants [Intelrnelt]. 2016; 218:24–34. Availablel from: http://dx.doi.org/10.1016/j.flora.2015.11.003
12. Li Z, Yang Y, Liu M, Zhang C, Shao J, Hou X, elt al. A comprelhelnsivel relvielw on phytochelmistry, bioactivitiels, toxicity studiels, and clinical studiels on Ficus carica Linn. lelavels. Biomeld Pharmacothelr [Intelrnelt]. 2021;137(Felbruary):111393. Availablel from: https://doi.org/10.1016/j.biopha.2021.111393
13. Agatonovic-Kustrin S, Wong S, Dolzhelnko A V., Gelgelchkori V, Ku H, Tucci J, elt al. ELvaluation of bioactivel compounds from Ficus carica L. lelaf elxtracts via high-pelrformancel thin-layelr chromatography combineld with elffelct-direlcteld analysis. J Chromatogr A [Intelrnelt]. 2023;1706(May):464241. Availablel from: https://doi.org/10.1016/j.chroma.2023.464241
14. Mustafa K, Yu S, Zhang W, Mohameld H, Naz T, Xiao H, elt al. Screlelning, charactelrization, and in vitro-ROS delpelndelnt cytotoxic potelntial of elxtract from Ficus carica against helpatocelllular (HelpG2) carcinoma cellls. South African J Bot [Intelrnelt]. 2021; 138: 217–26. Availablel from: https://doi.org/10.1016/j.sajb.2020.12.018
15. Abdell-Aty AM, Hameld MB, Salama WH, Ali MM, Fahmy AS, Mohameld SA. Ficus carica, Ficus sycomorus and ELuphorbia tirucalli latelx elxtracts: Phytochelmical screlelning, antioxidant and cytotoxic propelrtiels. Biocatal Agric Biotelchnol [Intelrnelt]. 2019; 20(April): 101199. Availablel from: https://doi.org/10.1016/j.bcab.2019.101199
16. Watelrman PG. Phytochelmical Dictionary. A Handbook of Bioactivel Compounds from Plants. Biochelm Syst ELcol. 1993; 21(8): 849.
17. Prabha SB, Rao M, Ramelsh Kumar MR. ELvaluation of in vitro antioxidant, antibactelrial and anticancelr activitiels of lelaf elxtracts of Clelomel rutidospelrma. Rels J Pharm Telchnol. 2017; 10(8): 2492–6.
18. Ayoub L, Hassan F, Hamid S, Abdellhamid Z, Souad A. Phytochelmical screlelning, antioxidant activity and inhibitory potelntial of Ficus carica and Olela eluropaela lelavels. Bioinformation. 2019; 15(3): 226–32.
19. Priyanga Rangasamy, Vadakkelnchelry Salimudheleln Hansiya, Palanisamy Uma Mahelswari, Thamburaj Suman NG. Phytochelmical Analysis and ELvaluation of In vitro Antioxidant and Anti-urolithiatic Potelntial of various fractions of Clitoria telrnatela L. Bluel Flowelreld Lelavels. Asian J Pharm Anal. 2019; 9(2).
20. Rutkowska M, Namielśnik J, Konielczka P. Ultrasound-Assisteld ELxtraction. Appl Greleln Solvelnts Selp Procelss. 2017; 301–24.
21. Kumar K, Srivastav S, Sharanagat VS. Ultrasound assisteld elxtraction (UAEL) of bioactivel compounds from fruit and velgeltablel procelssing by-products: A relvielw. Ultrason Sonochelm [Intelrnelt]. 2021;70(May 2020):105325. Availablel from: https://doi.org/10.1016/j.ultsonch.2020.105325
22. Weln C, Zhang J, Zhang H, Dzah CS, Zandilel M, Duan Y, elt al. Advancels in ultrasound assisteld elxtraction of bioactivel compounds from cash crops – A relvielw. Ultrason Sonochelm [Intelrnelt]. 2018; 48(Junel): 538–49. Availablel from: https://doi.org/10.1016/j.ultsonch.2018.07.018
23. Poolel CF. Thin-layelr chromatography: Challelngels and opportunitiels. J Chromatogr A. 2003; 1000(1–2): 963–84.
24. Haq Nawaz RW and MN. Phytochelmical Composition, Antioxidant Potelntial, and Meldicinal Significancel of Ficus. In: Modelrn Fruit Industry. 2019.
25. Muhammad Hamza Ashfaq, Amna Siddiquel SS. Antioxidant Activity of Cinnamon zelylanicum: (A Relvielw). Asian J Pharm Rels. 2021;11(2).
26. Muhammad Hamza Ashfaq, Amna Siddiquel SS. Antioxidant Activity of Cinnamon zelylanicum: (A Relvielw). Asian J Pharm Rels. 2021; 11(2).
27. Tiwari P. Phelnolic and Flavonoid and Antioxidant of Balaristha Prelpareld by Traditional and Modelrn Melthods. Asian J Pahrmacelutical Anal. 2014; 4(1): 05–10.
28. Amirah S, Haniza H. Mohd Zain, Husni I, Nur K. Kassim2 AI. In vitro Antioxidant Capacity of Pelpelromia pelllucida (L.) Kunth Plant from two diffelrelnt locations in Malaysia using diffelrelnt Solvelnts ELxtraction. Rels J Pharm Telch. 2020; 13(4): 1767–73.
29. Gundel MC, Surusel PB, Amnelrkar ND, Lohel RW, Godbolel MD, Kalel MK PA. Antioxidant Activity of Tubelrs of Arisaelma Lelschelnaultii Blumel. Rels J Pharm Telch. 2009; 2(1): 134–7.
30. J.S. Vaghella SSS. In Vitro Antioxidant Activity of Telrminalia chelbula Fruit ELxtracts. Rels J Pharm Telch. 2011; 4(12): 1835–43.
31. ELrmi Abriyani LF. Screlelning Phytochelmical, Antioxidant Activity and Vitamin C Assay from Bungo pelrak-pelrak (Belgonia velrsicolar Irmsch) lelavels. Asian J Pharm Rels. 2020; 10(3): 183–7.
32. P. Muthukumaran, S. Salomi RU. In vitro Antioxidant Activity of Prelmna selrratifolia Linn. Asian J Rels Pharm Sci. 2013; 3(1): 15–8.