Author(s):
Vishal Gupta, Navneet Garud, Rajendra Chauhan, Hemant Mourya, Pawan Kushwah, Ramakant Joshi
Email(s):
joshiram78@gmail.com
DOI:
10.52711/0974-360X.2024.00901 
Address:
Vishal Gupta1, Navneet Garud1, Rajendra Chauhan1, Hemant Mourya1, Pawan Kushwah1, Ramakant Joshi2*
1School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, 474011, India.
2Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, 474005, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
The present investigation was aimed to prepare alginate-acacia microspheres by ionic cross-linking method or Ionotropic gelation method. Systematic preformulation study performed as per the standard procedure as described for the identification and authentication of drug sample. Calibration curve was prepared as spectrum of this solution was recorded in 200-400 nm range using U.V. spectrophotometer. FT-IR spectrum of standard drug was done by FT-IR from 400-4000cm-1 by using potassium bromide. Total 8 formulations (F1-F8) were prepared. The microsphere of Vildagliptin was preparedusing ionotropic gelation system also exhibited the smallest particle size of 176.65 micrometres. Formulation F4 exhibited the highest percentage entrapment efficiency of 78.85% with the highest percentage of mucoadhesion (70.23%). Formulation F4 has a zeta potential of -36.45 mV. A zeta potential with a magnitude above 30 mV (either positive or negative) typically indicates good stability in colloidal systems. The optimized formulation of the Vildagliptin loaded acacia-sodium alginate microspheres was tested after 3 months of storage at room temperature.
Cite this article:
Vishal Gupta, Navneet Garud, Rajendra Chauhan, Hemant Mourya, Pawan Kushwah, Ramakant Joshi. Formulation and evaluation of antidiabetic mucoadhesive microspheres. Research Journal Pharmacy and Technology. 2024;17(12):5944-8. doi: 10.52711/0974-360X.2024.00901
Cite(Electronic):
Vishal Gupta, Navneet Garud, Rajendra Chauhan, Hemant Mourya, Pawan Kushwah, Ramakant Joshi. Formulation and evaluation of antidiabetic mucoadhesive microspheres. Research Journal Pharmacy and Technology. 2024;17(12):5944-8. doi: 10.52711/0974-360X.2024.00901 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-38
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