Author(s):
Chandrappa Chinna Poojari, Sanjana, Levin Anbu Gomez, Saba Shirin, Ankit Kumar, Gangadahosahalli Krishnegowda Puneetha, Praveen Kumar Guttula, Rajkumar Sekar, Prathap Somu, Akhilesh Kumar Yadav
Email(s):
yadavbasti@gmail.com , prathaps1987@gmail.com
DOI:
10.52711/0974-360X.2024.00885 
Address:
Chandrappa Chinna Poojari1, Sanjana1, Levin Anbu Gomez2, Saba Shirin3,4, Ankit Kumar5, Gangadahosahalli Krishnegowda Puneetha6, Praveen Kumar Guttula7, Rajkumar Sekar8, Prathap Somu9*, Akhilesh Kumar Yadav10,11*
1Department of Microbiology, Shridevi Institute of Allied Health Sciences, Tumakuru, 572106, India.
2Division of Biotechnology, School of Agricultural Sciences, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, 641114, India.
3Department of Environmental Science, School of Vocational Studies and Applied Sciences, Gautam Buddha University, Greater Noida, 201312, India.
4Department of Mining Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
5Lohum Cleantech Pvt. Ltd., Kasna Industrial Area, D-184, Site V, Greater Noida, 201306, India.
6Department of Botany, Yuvaraja’s College, University of Mysore, Mysuru, 570005, India.
7Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ot
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
Neuroactive peptides derived from venomous species have proven to be used as a lead compound for treating neurological diseases. In the present study, the primary structure of the peptide toxins of snakes, scorpions, spiders, cone snails, honey bees, and sea anemones was recovered from different toxin databases. The 3-D structures of the peptide toxins were analyzed with respect to secondary structural elements such as cysteine patterns and disulfide connectivity’s using PYMOL. Their interaction with ion channels/receptors was studied because of its pharmacological importance. The toxins retrieved were found to have – C–Xn–C–Xn–CC–Xn–C–Xn–C-- cysteine pattern for n=1 that was the same --C---C---CC---C---C— cysteine pattern of ?-conotoxin and hanatoxin, but with a varying intervening non-cysteine residue between cysteines. Hence, these provide insight for structure-based drug design using these peptide toxin scaffolds. Given the optimal molecular weight and specificity of peptides compared to conventional small molecule drugs, peptides are considered future next-generation drug candidates.
Cite this article:
Chandrappa Chinna Poojari, Sanjana, Levin Anbu Gomez, Saba Shirin, Ankit Kumar, Gangadahosahalli Krishnegowda Puneetha, Praveen Kumar Guttula, Rajkumar Sekar, Prathap Somu, Akhilesh Kumar Yadav. Identification of Neuroactive Peptide from Venomous Species using Structural Analysis: A Possible Neuronal Therapeutic Candidate. Research Journal Pharmacy and Technology. 2024;17(12):5825-8. doi: 10.52711/0974-360X.2024.00885
Cite(Electronic):
Chandrappa Chinna Poojari, Sanjana, Levin Anbu Gomez, Saba Shirin, Ankit Kumar, Gangadahosahalli Krishnegowda Puneetha, Praveen Kumar Guttula, Rajkumar Sekar, Prathap Somu, Akhilesh Kumar Yadav. Identification of Neuroactive Peptide from Venomous Species using Structural Analysis: A Possible Neuronal Therapeutic Candidate. Research Journal Pharmacy and Technology. 2024;17(12):5825-8. doi: 10.52711/0974-360X.2024.00885 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-22
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