Author(s): Aasiya J. Dadel, Padma L. Ladda, Nilofar S. Naikwade, Tabassum Shikalgar

Email(s): aasiyadadel@gmail.com

DOI: 10.52711/0974-360X.2024.00883   

Address: Aasiya J. Dadel1,2, Padma L. Ladda1, Nilofar S. Naikwade1, Tabassum Shikalgar1
1Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli – 416416.
2Department of Pharmacology, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat 410201, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 12,     Year - 2024


ABSTRACT:
Breast cancer remains the leading cause of cancer-related deaths among women globally. The potential of various natural and dietary agents in reducing breast cancer risk is well recognized. Currently, chemotherapy serves as the primary treatment for breast cancer, yet its cytotoxic effects on normal cells and the development of drug resistance pose significant challenges. Hence, there is a pressing need to develop safer and more effective anticancer therapies. V. aconitifolia seeds are rich in phytochemicals such as alkaloids, phenols, flavonoids, phytic acids, trypsin, and chemotrypsin inhibitors. The acetone extract of V. aconitifolia has been noted for its anticancer and antioxidant properties, with abundant trypsin inhibitors and vicilins contributing to these activities. Despite the high presence of anticancer phytoconstituents in its seeds, scientific evaluation of V. aconitifolia for its anticancer potential remains limited. Therefore, this study aimed to investigate V. aconitifolia as a potential anticancer agent.In this research, the anticancer efficacy of acetone extract from V. aconitifolia seeds was evaluated using both in vitro and in vivo methods. Breast cancer was induced in Wistar rats through intragastric administration of 7,12-dimethylbenz[a]anthracene (DMBA) at 80 mg/kg body weight. Pretreatment with V. aconitifolia extract (200 mg/kg BW) demonstrated effectiveness against DMBA-induced mammary carcinoma. Administration of V. aconitifolia normalized elevated SGOT and SGPT levels, and restored antioxidant levels to within normal limits. Additionally, body weight and hematological parameters of animals in the pretreatment group remained within normal ranges. Histopathological studies further confirmed the efficacy of V. aconitifolia against DMBA-induced ductal and invasive carcinoma. These findings collectively underscore the preventive potential of V. aconitifolia against DMBA-induced mammary carcinoma in Wistar rats.


Cite this article:
Aasiya J. Dadel, Padma L. Ladda, Nilofar S. Naikwade, Tabassum Shikalgar. Effect of Vigna aconitifolia (Moth Bean) Seed Extract In 7,12 Dimethyl Benz[A] Anthracene Dmba-Induced Breast Cancer in Rats. Research Journal Pharmacy and Technology. 2024;17(12):5809-5. doi: 10.52711/0974-360X.2024.00883

Cite(Electronic):
Aasiya J. Dadel, Padma L. Ladda, Nilofar S. Naikwade, Tabassum Shikalgar. Effect of Vigna aconitifolia (Moth Bean) Seed Extract In 7,12 Dimethyl Benz[A] Anthracene Dmba-Induced Breast Cancer in Rats. Research Journal Pharmacy and Technology. 2024;17(12):5809-5. doi: 10.52711/0974-360X.2024.00883   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-20


REFERENCES:
1.    Cancer.gov. What Is Cancer? https://www.cancer.gov/about-cancer/understanding/what-is-cancer (accessed August 28, 2024).
2.    Sawant, V. J.; Bamane, S. R.; Shejwal, R. V.; Patil, S. B. Comparison of Drug Delivery Potentials of Surface Functionalized Cobalt and Zinc Ferrite Nanohybrids for Curcumin in MCF-7 Breast Cancer Cells. J. Magn. Magn. Mater. 2016; 417: 222-229.
3.    Das, M.; Kandimalla, R.; Gogoi, B.; Dutta, K. N.; Choudhary, P. P.; Talukdar, N. C. Mahanine, A Dietary Phytochemical, Represses Mammary Tumor Burden in Rat and Inhibits Subtype Regardless Breast Cancer Progression through Suppressing Self-Renewal of Breast Cancer Stem Cells. Pharmacol. Res. 2019; 146: 1043.
4.    Adefisa, A.; Owumi, S.; Adaramoye, O. Root Bark Extract of Calliandra portoricensis (Jacq.) Benth Chemoprevents N-Methyl-N-Nitrosourea-Induced Mammary Gland Toxicity in Rats. J. Ethnopharmacol. 2019; 233: 22-.
5.    Jose, B. E.; Muralidharan, P. Effect of Azima tetracantha Lam on Human Breast Cancer Cells MCF-7. Res. J. Sci. Technol. 2019; 11(2): 109-112.
6.    Sasikala, M.; Sundaraganapathy, R.; Mohan, S. MTT Assay on Anticancer Properties of Phytoconstituents from Ipomoea aquatica Forsskal Using MCF-7 Cell Lines for Breast Cancer in Women. Res. J. Pharm. Technol. 2020; 13(3): 1356-1360.
7.    Faustino-Rocha, A. I.; Ferreira, R.; Oliveira, P. A.; Gama, A.; Ginja, M. N-Methyl-N-Nitrosourea as a Mammary Carcinogenic Agent. Tumor Biol. 2015; 36(12): 9095-9117.
8.    Caputo, L.; Cornara, L.; Bazzicalupo, M.; De Francesco, C.; De Feo, V.; Trombetta, D.; Smeriglio, A. Chemical Composition and Biological Activities of Essential Oils from Peels of Three Citrus Species. Molecules. 2020: 25(8): 1890.
9.    Wang, Z.; Zhang, X. Chemopreventive Activity of Honokiol against 7,12-Dimethylbenz[a]anthracene-Induced Mammary Cancer in Female Sprague Dawley Rats. Front. Pharmacol. 2017; 8: 320.
10.    Kaleem, A.; Ahmad, S.; Hasan, M. Vigna aconitifolia (Jacq.) Marechal (Papilionaceae): A Review of Medicinal Uses, Phytochemistry and Pharmacology. J. Pharmacogn. Phytochem. 2020; 9(1): 1353-1355.
11.    Karnam, K. C.; Ellutla, M.; Bodduluru, L. N.; Kasala, E. R.; Uppulapu, S. K.; Kalyankumarraju, M.; Lahkar, M. Preventive Effect of Berberine against DMBA-Induced Breast Cancer in Female Sprague Dawley Rats. Biomed. Pharmacother. 2017; 92: 207-214.
12.    Das, M.; Kandimalla, R.; Gogoi, B.; Dutta, K. N.; Choudhary, P. P.; Talukdar, N. C. Mahanine, A Dietary Phytochemical, Represses Mammary Tumor Burden in Rat and Inhibits Subtype Regardless Breast Cancer Progression through Suppressing Self-Renewal of Breast Cancer Stem Cells. Pharmacol. Res. 2019; 146: 1043.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available