Author(s):
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen
Email(s):
priyanka2pp@gmail.com
DOI:
10.52711/0974-360X.2024.00880 
Address:
Priyanka Dubey1*, Prinsi Sahpuriya2, Savita Yadav3, Ritesh Kumar Gupta4, Ritu Deheriya5, Vivek Chourasia6, Sachin Kumar Yadav7, Supriya Gupta8, Neha Parveen9
1,2,3,4,5Department of Pharmaceutics, IES Institute of Pharmacy, Bhopal 462044, Madhya Pradesh, India.
6Department of Pharmaceutics, Globus College of Pharmacy, Bhopal 462045, Madhya Pradesh, India.
7,8RDS College of Pharmacy, Kushaw Bhaupur, Jaunpur 222136, India.
9 Prasad Institute of Technology, Jaunpur 222002, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
In this research, we developed a novel approach to formulate colon-specific matrix tablets containing Aceclofenac. Employing the wet granulation method, we integrated guar gum as the polymeric matrix and harnessed the potential of probiotics as targeting aids. Our investigation revealed a remarkable capability of this methodology to achieve colonic release of the drug, even in the absence of colonic microflora, while ensuring sustained drug release from the formulations. The outcomes underscore the promise of the probiotic-assisted procedure in yielding matrix tablets with exceptional release behavior, actively targeting drug delivery to the colon. Consequently, this innovative delivery system presents a unique and promising strategy for the treatment of stomach ulcers and other gastrointestinal ailments. This research represents a significant advancement in pharmaceutical science, offering a distinctive approach to address targeted drug delivery challenges in gastrointestinal therapeutics.
Cite this article:
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen. Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals. Research Journal Pharmacy and Technology. 2024;17(12):5790-8. doi: 10.52711/0974-360X.2024.00880
Cite(Electronic):
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen. Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals. Research Journal Pharmacy and Technology. 2024;17(12):5790-8. doi: 10.52711/0974-360X.2024.00880 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-17
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