Author(s):
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen
Email(s):
priyanka2pp@gmail.com
DOI:
10.52711/0974-360X.2024.00880
Address:
Priyanka Dubey1*, Prinsi Sahpuriya2, Savita Yadav3, Ritesh Kumar Gupta4, Ritu Deheriya5, Vivek Chourasia6, Sachin Kumar Yadav7, Supriya Gupta8, Neha Parveen9
1,2,3,4,5Department of Pharmaceutics, IES Institute of Pharmacy, Bhopal 462044, Madhya Pradesh, India.
6Department of Pharmaceutics, Globus College of Pharmacy, Bhopal 462045, Madhya Pradesh, India.
7,8RDS College of Pharmacy, Kushaw Bhaupur, Jaunpur 222136, India.
9 Prasad Institute of Technology, Jaunpur 222002, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 12,
Year - 2024
ABSTRACT:
In this research, we developed a novel approach to formulate colon-specific matrix tablets containing Aceclofenac. Employing the wet granulation method, we integrated guar gum as the polymeric matrix and harnessed the potential of probiotics as targeting aids. Our investigation revealed a remarkable capability of this methodology to achieve colonic release of the drug, even in the absence of colonic microflora, while ensuring sustained drug release from the formulations. The outcomes underscore the promise of the probiotic-assisted procedure in yielding matrix tablets with exceptional release behavior, actively targeting drug delivery to the colon. Consequently, this innovative delivery system presents a unique and promising strategy for the treatment of stomach ulcers and other gastrointestinal ailments. This research represents a significant advancement in pharmaceutical science, offering a distinctive approach to address targeted drug delivery challenges in gastrointestinal therapeutics.
Cite this article:
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen. Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals. Research Journal Pharmacy and Technology. 2024;17(12):5790-8. doi: 10.52711/0974-360X.2024.00880
Cite(Electronic):
Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritesh Kumar Gupta, Ritu Deheriya, Vivek Chourasia, Sachin Kumar Yadav, Supriya Gupta, Neha Parveen. Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals. Research Journal Pharmacy and Technology. 2024;17(12):5790-8. doi: 10.52711/0974-360X.2024.00880 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-17
REFERENCES:
1. Hirani JJ. Rathod DA. Vadalia KR. Orally disintegrating tablets: A review. Tropical Journal of Pharmaceutical Research. 2009; 8(2): 161-172.
2. Yadav VB. Yadav AV. Liquisolid granulation technique for tablet manufacturing: an overview. Journal of Pharmacy Research. 2009; 2(4): 670-674.
3. Chien YW. Controlled and modulated-release drug delivery systems. Encyclopedia of Pharmaceutical Technology. 1990; 280: 313.
4. Ohara T. Kitamura S. Kitagawa T. Terada K. Dissolution mechanism of poorly water-soluble drug from extended release solid dispersion system with ethylcellulose and hydroxypropylmethylcellulose. International Journal of Pharmaceutics. 2005; 302(1-2): 95-102.
5. Krishnaiah Y. Satyanarayana S. Prasad YR. Rao SN. Evaluation of guar gum as a compression coat for drug targeting to colon. International Journal of Pharmaceutics. 1998; 171(2): 137-146.
6. Yang L. Chu JS. Fix JA. Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. International Journal of Pharmaceutics. 2002; 235(1-2): 1-5.
7. Orlu M. Cevher E. Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. International Journal of Pharmaceutics. 2006; 318(1-2): 103-117.
8. Asghar LF. Chandran S. Multiparticulate formulation approach to colon specific drug delivery: current perspectives. Journal of Pharmacy and Pharmaceutical Sciences. 2006; 9(3): 327-338.
9. Brahma PG. Thakur N. Jain S. Patel P. Patel D. Jain N. Jain NP. A Comprhensive Review On: Colon Specific Drug Delivery System (CSDDS). Journal of Pharmacy Research. 2010; 3(7): 1625-1629.
10. Challa T. Vynala V. Allam KV. Colon specific drug delivery systems: A review on primary and novel approaches. International Journal of Pharmaceutical Sciences Review and Research. 2011; 7(2): 171-181.
11. Ahmed IS. Ayres JW. Comparison of in vitro and in vivo performance of a colonic delivery system. International Journal of Pharmaceutics. 2011; 409(1-2): 169-77.
12. Ahuja V. Tandon RK. Inflammatory bowel disease in the Asia–Pacific area: a comparison with developed countries and regional differences. Journal of Digestive Diseases. 2010; 11(3): 134-147.
13. Ashford M. Fell J. Attwood D. Sharma H. Woodhead P. An evaluation of pectin as a carrier for drug targeting to the colon. Journal of Controlled Release. 1993; 26(3): 213-220.
14. Patel MM. Amin A. Recent trends in microbially and/or enzymatically driven colon-specific drug delivery systems. Critical Review in Therapeutic Drug Carrier Systems. 2011; 28(6): 489-552.
15. Gupta BP. Thakur N. Jain S. Patel P. Patel D. Jain N. Jain NP. A Comprehensive review on: Colon specific drug delivery system. Journal of Pharmacy Research. 2010; 3(7): 1625-1629.
16. Chourasia MK. Jain SK. Pharmaceutical approaches to colon targeted drug delivery systems. Journal of Pharmacy and Pharmaceutical Sciences. 2003; 6(1): 33-66.
17. Luppi B. Bigucci F. Cerchiara T. Mandrioli R. Di Pietra AM.Zecchi V. New environmental sensitive system for colon-specific delivery of peptidic drugs. International Journal of Pharmaceutics. 2008; 358(1-2): 44-49.
18. Vyas SP. Khar RK. Controlled drug delivery concepts and advances. Vallabh Prakashan. 2002; 1: 411-417.
19. Krishnaiah YS. Raju PV. Kumar BD. Bhaskar P.Satyanarayana V. Development of colon targeted drug delivery systems for mebendazole. Journal of Controlled Release. 2001; 77(1-2): 87-95.
20. Lee VH. Mukherjee SK. Drug delivery-oral colon-specific. Encyclopedia of Pharmaceutical Technology. New York: Marcel Dekker. 2002: 871-875.
21. Mahajan PS. Vispute GS. Palhal AP. Sarode S. Barhate S. Colon targeted microbeads: A novel approach in NDDS. World Journal of Pharmaceutical Research. 2017; 6(11): 280-292.
22. Lee J. Rho J. Yang Y. Kong H. Jung Y. Kim Y. Synthesis and in vitro evaluation of N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)-D, L-glycine as a colon-specific prodrug of 5-fluorouracil. Journal of Drug Targeting. 2007; 15(3): 199-205.
23. Ghosh PK. Gupta VB.Gondoliya B. Rathore MS. Probiotic-assisted colon-specific delivery of diclofenac sodium from guar gum matrix tablets: In vitro evaluation. Asian Journal of Pharmaceutics. 2010;4(4).
24. Chauhan P. Mehta N. Rathore MS. Jain A. Jain AK. Probiotic assisted colon targeted drug delivery system: research scope. Asian Journal of Pharmaceutical and Clinical Research. 2011; 4(2): 12-15.
25. Amara AA. Shibl A. Role of Probiotics in health improvement, infection control and disease treatment and management. Saudi Pharmaceutical Journal. 2015; 23: 107-114.
26. Dodoo CC. Wang J. Basit AW. Stapleton P. Gaisford S. Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. International Journal of Pharmaceutics. 2017; 530(1-2): 224-229.
27. Prakash A. Lone KD. Shukla A. Mandloi R. Ghosh V. Spectrophotometric estimation of mesalazine in tablet dosage form. Asian Journal of Research in Chemistry. 2008; 1(2): 80-82.
28. Rowe RC. Sheskey PJ. Owen SC Eds. In: Handbook of Pharmaceutical Excipients. 5th ed. Pharmaceutical Press, London 2006; 315-317.
29. Rowe RC. Sheskey PJ. Owen SC Eds. In: Handbook of Pharmaceutical Excipients. 5th ed. Pharmaceutical Press, London 2006; 389-395.
30. Rowe RC. Sheskey PJ. Owen SC Eds. In: Handbook of Pharmaceutical Excipients. 5th ed. Pharmaceutical Press, London 2006; 430-433.
31. Rowe RC.Sheskey PJ. Owen SC Eds. In: Handbook of Pharmaceutical Excipients. 5th ed. Pharmaceutical Press, London 2006; 767-769.
32. Radhika PR. Pal TK. Sivakumar T. Formulation and evaluation of sustained release matrix tablets of glipizide. Iran Journal of Pharmarmaceutical Science. 2009; 5(4): 205-214.
33. Indian Pharmacopoiea.6thed, Vol II, The Indian Pharmacopoeial Commission, Ghaziabad 2010; 751-754.