Author(s): Anannya Bose, Subhabrota Majumdar, Asim Halder

Email(s): a.bose.midnapore@gmail.com

DOI: 10.52711/0974-360X.2024.00876   

Address: Anannya Bose1*, Subhabrota Majumdar2, Asim Halder3
1APC College of Pharmacy, Daluigacha, Singur, West Bengal 712409, India.
2Calcutta Institute of Pharmaceutical Technology & A.H.S, Uluberia, Howrah, West Bengal 711316, India.
3Department of Pharmaceutical Technology, Adamas University, Barasat, West Bengal 700126, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 12,     Year - 2024


ABSTRACT:
This study focuses on the development and characterization of a novel liposomal gel formulation intended for ocular drug delivery. The liposomal gel was prepared using the thin-film hydration method, with Tween-80 employed as a stabilizing agent to prevent aggregation. The encapsulation efficiency, particle size, zeta potential, and polydispersity index (PDI) of the liposomal formulation containing the active ingredient, timolol maleate, were evaluated. The encapsulation efficiency was found to be 57.47%, with a particle size of 340.8 nm and a zeta potential of -29.0 mV. The polydispersity index was determined to be 0.576, indicating a uniform distribution of liposome sizes and good stability of the formulation. The developed liposomal gel aims to enhance drug permeation, optimize therapeutic response, and minimize potential side effects associated with conventional forms of the drug. The incorporation of multilamellar vesicles into the gel matrix is expected to prolong drug residence time at the ocular surface, thereby improving drug absorption and reducing dosing frequency. Additionally, the mucoadhesive properties of the carbopol 940 gel base further enhance ocular residence time, leading to improved patient compliance and comfort. Overall, the prepared liposomal gel formulation shows promise as an effective ocular drug delivery system. Further in vitro and in vivo studies are warranted to evaluate its pharmacokinetic and pharmacodynamic profiles, as well as its safety and efficacy for clinical use.


Cite this article:
Anannya Bose, Subhabrota Majumdar, Asim Halder. Preparation, In-Vitro and Ex-Vivo Evaluation of Liposomal Gel Delivery system for Timolol Maleate. Research Journal Pharmacy and Technology. 2024;17(12):5761-7. doi: 10.52711/0974-360X.2024.00876

Cite(Electronic):
Anannya Bose, Subhabrota Majumdar, Asim Halder. Preparation, In-Vitro and Ex-Vivo Evaluation of Liposomal Gel Delivery system for Timolol Maleate. Research Journal Pharmacy and Technology. 2024;17(12):5761-7. doi: 10.52711/0974-360X.2024.00876   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-12-13


REFERENCES:
1.    Sankar C, Muthukumar S, Arulkumaran G, Shalini S , Sundaraganapathy R, Sandra joji samuel. Formulation and Characterization of Liposomes containing Clindamycin and Green tea for Anti Acne. Research J. Pharm. and Tech. 2019; 12(12): 5977-5984. doi: 10.5958/0974-360X.2019.01038.2
2.    Smita Nayak, Madhuri Jadhav, Vaidhun Bhaskar. Recent Advances in Ocular Drug Delivery Systems. Research J. Pharm. and Tech. 2016; 9(7): 995-1006. doi: 10.5958/0974-360X.2016.00189.X
3.    Revathy V. Nair, Sreeja C. Nair, Anoop K.R. Current Trends in Ocular drug Delivery Systems and its Applications. Research J. Pharm. and Tech. 2015; 8(5): 629-636. doi: 10.5958/0974-360X.2015.00101.8
4.    Raghad A. Dayoub, Antoun Laham. Preparation and In-vitro Evaluation of Timolol Maleate Loaded Ocular inserts by using various polymers. Research Journal of Pharmacy and Technology 2023; 16(3): 1259-1266. doi: 10.52711/0974-360X.2023.00208
5.    Shikha Baghel Chauhan, Vaishnavi Gupta. Recent Advances in Liposome. Research J. Pharm. and Tech. 2020; 13(4): 2051-2056. doi: 10.5958/0974-360X.2020.00369.8
6.    Chandan Yadav, Md. Asif, Juber Akhtar, Badruddeen, Mohammad Irfan Khan, Saquib, Tanweer, Mohammad Ahmad, Laiba Rind. An outline on Curcumin: Its pro-liposome and Liposome Formulations. Research J. Pharm. and Tech. 2020; 13(12): 6276-6283. doi: 10.5958/0974-360X.2020.01092.6
7.    M Padmasree, B A Vishwanath, Shankarrao Patil, Mythili S, Kirupakar B R. Formulation, Characterization and Stability Study of Encapsulated Anticancer drug in multilayered PEGylated Tumor targeting stealth Liposomes. Research J. Pharm. and Tech. 2019; 12(10): 4689-4695. doi: 10.5958/0974-360X.2019.00807.2
8.    Borshchevskiy G.I., Yarnykh T.G., Konovalenko V.A., Chabaniy V.N. Development of quality Indicators of liposomal Preparations "EFIAL". Research J. Pharm. and Tech. 2014; 7(8): 864-869.
9.    Hemanth A. R., G. B. Kiran Kumar, Prakash Goudanavar, Dhruva Sagar S. Formulation and Evaluation of Hydrogels containing Liposomes Entrapped with Antifungal Agent. Research Journal of Pharmacy and Technology. 2021; 14(9): 4947-0. doi: 10.52711/0974-360X.2021.00860
10.    Saumya Das, A.V Jithan, C. Raghunadha Guptha, Dharmajit Pattanayak. Proliposome Technique for Enhancement of Bioavailability of Metformin Hydrochloride. Research J. Pharm. and Tech. 2021; 14(2): 747-751. doi: 10.5958/0974-360X.2021.00130.X
11.    Stadnichenko A.V., Krasnopolsky Y.M., Yarnykh T.G. Standardization of Extrusion Parameters during Liposomal Oxaliplatin Creation. Research J. Pharm. and Tech. 2017; 10(3): 785-788. doi: 10.5958/0974-360X.2017.00147.0
12.    M. Yasmin Begum, Mahammed Rafi Shaik, K. Abbulu, M. Sudhakar. Ketorolac Tromethamine Loaded Liposomes: Development, Characterization and In Vitro Evaluation. Research J. Pharm. and Tech. 2011; 4(11): 1766-1771.
13.    Anju Elza Joseph, Shajan Abraham, Steffy P Raju, Haritha H Pillai, Feba Jose, Elessy Abraham. Formulation and Evaluation of Levofloxacin Stealth Liposome using different Polymers. Research J. Pharm. and Tech 2021; 14(3): 1493-1498. doi: 10.5958/0974-360X.2021.00265.1


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