Author(s):
Sumit Kumar, Sonakshi Antal, Dinesh Kumar, Rajni Tanwar, Imanshu, Amandeep Mor
Email(s):
drsumitkumar@cuh.ac.in , sonakshiantal@gmail.com , dineshpotlia123@gmail.com , amandeepmor55@gmail.com , rajnitanwar059@gmail.com , badhanimanshu@gmail.com
DOI:
10.52711/0974-360X.2024.00863
Address:
Sumit Kumar1, Sonakshi Antal2, Dinesh Kumar3*, Rajni Tanwar3, Imanshu3, Amandeep Mor4
1Department of Pharmaceutical Sciences, Central University of Haryana, Jant-Pali, Mahendargarh, India.
2SRM Institute of Science and Technology NCR campus, Uttar Pradesh, India.
3School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India.
4Research Scholar, Om Sterling Global University, Hisar, Haryana, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 11,
Year - 2024
ABSTRACT:
Cryptosomes are a promising medication delivery mechanism that improves stability, bioavailability, and targeted administration of pharmaceuticals. These lipid-based nanocarriers can encapsulate hydrophilic and hydrophobic medicines, making them useful for various therapeutic purposes. This review covers cryptosome features, preparation, and drug delivery applications, discussing lipid composition, surface modification, and encapsulation efficiency. Recent improvements have shown promise in improving medicinal efficacy and patient compliance. To accelerate bench-to-bedside translation, scale-up production, and regulatory issues are addressed. Cryptosomes are a promising drug delivery research frontier, with future research aiming to enhance treatment outcomes and eliminate side effects.
Cite this article:
Sumit Kumar, Sonakshi Antal, Dinesh Kumar, Rajni Tanwar, Imanshu, Amandeep Mor. Insights Into Novel Promising Drug Delivery System –Cryptosomes. Research Journal of Pharmacy and Technology. 2024; 17(11):5666-0. doi: 10.52711/0974-360X.2024.00863
Cite(Electronic):
Sumit Kumar, Sonakshi Antal, Dinesh Kumar, Rajni Tanwar, Imanshu, Amandeep Mor. Insights Into Novel Promising Drug Delivery System –Cryptosomes. Research Journal of Pharmacy and Technology. 2024; 17(11):5666-0. doi: 10.52711/0974-360X.2024.00863 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-11-71
REFERENCES:
1. Sharma Vijay K, Mishra D, Sharma A, Srivastava B. Liposomes: present prospective and future challenges. International Journal of Current Pharmaceutical Review and Research. 2010; Aug; 1(2): 6-16.
2. Selvaraju K, Prabhu KV, Karthick K, Preetha JP, Kumaran KS. Pharmacosomes-An Immense Potential Vesicular Constructs. Research Journal of Pharmaceutical Dosage Forms and Technology. 2011; 3(3): 84-6.
3. Weiner N, Martin F, Riaz M. Liposomes as a drug delivery system. Drug Development and Industrial Pharmacy. 1989; Jan 1; 15(10): 1523-54.
4. Kumar D, Sharma D, Singh G, Singh M, Rathore MS. Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery. International Scholarly Research Notices. 2012; 2012(1): 474830.
5. Laura Immordino M, Dosio F, Cattel L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. International Journal of Nanomedicine. 2006; Sep 15; 1(3): 297-315.
6. Saraf S, Paliwal S, Kaur CD, Saraf S. Sphingosomes a novel approach to vesicular drug delivery. Research Journal of Pharmacy and Technology. 2011; 4(5): 661-6.
7. Cevc GG. Drug-carrier and stability properties of the long-lived lipid vesicles.Cryptosomes, in vitro and in vivo. Journal of Liposome Research. 1992; Jan 1; 2(3): 355-68.
8. Blume G, Cevc G. Molecular mechanism of the lipid vesicle longevity in vivo. Biochimicaet Biophysica Acta (BBA)-Biomembranes. 1993; Mar 14; 1146(2): 157-68. https://doi.org/10.1016/0005-2736(93)90351-Y
9. Allen TM, Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS letters. 1987; Oct 19; 223(1): 42-6. https://doi.org/10.1016/0014-5793(87)80506-9
10. Mulla TS, Thorat MS, Rayate Y, Nitalikar M. Liposome as a drug carrier. Asian Journal of Research in Pharmaceutical Science. 2019; 9(2): 141-7. http://dx.doi.org/10.5958/2231-5659.2019.00021.3
11. Dadure KM, Haldar AG. Cryptosomes: A Novel Promising Drug Delivery System. Int J Med Phar Sci| Vol. 2017; Jan; 7(01): 1. http://dx.doi.org/10.31782/IJMPS.2017.7101
12. Blume G, Cevc G. Circulation time of cryptosomes. Bio Chem Bio PhysActa. 1993;1146: 157-68.
13. Kegade P, Gade A, Sawant R, Parkar S. Liposomal drug delivery in Cancer. Asian Journal of Pharmaceutical Research. 2020; 10(4): 293-8. http://dx.doi.org/10.5958/2231-5691.2020.00050.7
14. Hemalatha B, Kalpana M, Rekha BS, Varalakshmi A, Padmalatha K. An Overview on Nasal Drug Delivery System. Asian Journal of Pharmaceutical Research. 2022; 12(3): 249-58. http://dx.doi.org/10.52711/2231-5691.2022.00041
15. Ciobanu M, Heurtault B, Schultz P, Ruhlmann C, Muller CD, Frisch B. Layersome: development and optimization of stable liposomes as drug delivery system. International Journal of Pharmaceutics. 2007; Nov 1; 344(1-2): 154-7. https://doi.org/10.1016/j.ijpharm.2007.05.037
16. Kirby C, Clarke J, Gregoriadis G. Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochemical Journal. 1980; Feb 15; 186(2): 591-8. https://doi.org/10.1042/bj1860591
17. Nikam NR, Patil PR, Vakhariya RR, Magdum CS. Liposomes: A novel drug delivery system: An overview. Asian Journal of Pharmaceutical Research. 2020; 10(1): 23-8. http://dx.doi.org/10.5958/2231-5691.2020.00005.2
18. Gangwar M, Singh R, Goel RK, Nath G. Recent advances in various emerging vescicular systems: An overview. Asian Pacific Journal of Tropical Biomedicine. 2012; Feb 1; 2(2): S1176-88. https://doi.org/10.1016/S2221-1691(12)60381-5
19. Makeshwar KB, Wasankar SR. Niosome: a novel drug delivery system. Asian Journal of Pharmaceutical Research. 2013; 3(1): 16-20.
20. Dipali SR, Kulkarni SB, Betageri GV. Comparative study of separation of non-encapsulated drug from unilamellar liposomes by various methods. Journal of Pharmacy and Pharmacology. 1996; Nov; 48(11): 1112-5. https://doi.org/10.1111/j.2042-7158.1996.tb03904.x
21. Gidde ND, Raut ID, Nitalikar MM, Mohite SK, Magdum CS. Pharmacosomes as drug delivery system: An overview. Asian Journal of Pharmaceutical Research. 2021; 11(2): 122-7. 10.52711/2231-5691.2021.00023
22. Walker SA, Kennedy MT, Zasadzinski JA. Encapsulation of bilayer vesicles by self-assembly. Nature. 1997; May 1; 387(6628): 61-4. https://doi.org/10.1038/387061a0
23. More SB, Nandgude TD, Poddar SS. Vesicles as a tool for enhanced topical drug delivery. Asian J Pharm. 2016; Jul 1; 10(3): S196-208.
24. Allen TM, Hansen C, Rutledge J. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochimicaet Biophysica Acta (BBA)-Biomembranes. 1989; May 19; 981(1): 27-35. https://doi.org/10.1016/0005-2736(89)90078-3
25. Shinde NG, Aloorkar NH, Kulkarni AS. Recent advances in vesicular drug delivery system. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 6(2): 110-20.
26. Chavan MB, Tarade DP, Jain RS. A Short Review on Liposome. 2022: 49-51. 10.52711/2231-5659.2022.00009
27. Lokhande SS. Microemulsions as promising delivery systems: A review. Asian Journal of Pharmaceutical Research. 2019; 9(2): 90-6. 10.5958/2231-5691.2019.00015.7