Author(s):
Gautami Deepak Khalap, Prasad Desai, Suwarna Suresh Bobde
Email(s):
suwarnabobde@gmail.com
DOI:
10.52711/0974-360X.2024.00844 
Address:
Gautami Deepak Khalap1, Prasad Desai1, Suwarna Suresh Bobde2
1Department of Pharmaceutics P.E. S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa, India.
2Assistant Professor, Department of Pharmaceutics, P.E. S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 11,
Year - 2024
ABSTRACT:
The present study aims to formulatea gastroretentive drug delivery system of domperidone maleate using Methocel DC2 premium excipients for cost-effective manufacturing and desired release performance. An experimental design of nine formulations was developed using three factors at two levels with a centre point for the study. The effect of formulation variablesi.e., concentration of Methocel DC2 K100M, Methocel DC2 K4M and potassium bicarbonate on the floating lag time, drug release at the end of 2 hours, 8 hours, 10 hours and 15 hours were studied. The formulations were evaluated for weight variation, thickness, hardness, friability, total floating time, floating lag time and assay. All the formulated tablets were found to be floating with acceptable hardness. The concentration of Methocel DC2 K100M, Methocel DC2 K4M and Potassium bicarbonate was found to have an effect on floating lag time and drug release. Formulation FC5 was found to be optimised formulation. It was concluded from the study that gastroretentive floating tablet of domperidone maleate could serve as once-a-day formulation.
Cite this article:
Gautami Deepak Khalap, Prasad Desai, Suwarna Suresh Bobde. Design and Statistical Optimization of Gastroretentive Drug Delivery System of Domperidone Maleate. Research Journal of Pharmacy and Technology. 2024; 17(11):5525-0. doi: 10.52711/0974-360X.2024.00844
Cite(Electronic):
Gautami Deepak Khalap, Prasad Desai, Suwarna Suresh Bobde. Design and Statistical Optimization of Gastroretentive Drug Delivery System of Domperidone Maleate. Research Journal of Pharmacy and Technology. 2024; 17(11):5525-0. doi: 10.52711/0974-360X.2024.00844 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-11-52
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