Author(s):
Rory A. Hutagalung, Giovani, Kristina Simanjuntak, Cut Fauziah, Hany Yusmaini, Meiskha Bahar, Niniek Hardini, Siti Nurbaya, Vivitri D. Prasasty
Email(s):
rory.hutagalung@atmajaya.ac.id , vivitri.prasasty@unas.ac.id
DOI:
10.52711/0974-360X.2024.00842 
Address:
Rory A. Hutagalung1*, Giovani1, Kristina Simanjuntak2, Cut Fauziah3, Hany Yusmaini4, Meiskha Bahar5, Niniek Hardini6, Siti Nurbaya7, Vivitri D. Prasasty8*
1Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia.
2Department of Biochemistry, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia.
3Department of Biology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia.
4Department of Pharmacology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia.
5Department of Microbiology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia.
6Department of Histology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta 12450, Indonesia.
7Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia.
8Depa
Published In:
Volume - 17,
Issue - 11,
Year - 2024
ABSTRACT:
Nanoparticles have gained significant attention in various fields, including medicine and materials science, due to their unique properties and potential applications. In particular, the synthesis of nanoparticles using environmentally friendly methods, such as green synthesis involving plant extracts, has garnered interest for its sustainability and potential biomedical applications. This study aimed to synthesize gold nanoparticles in a green environment using Manilkara zapota leaf extract and evaluate their antibacterial properties. The nanoparticles exhibited antibacterial activity against Escherichia coli, Staphylococcus aureus, and Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Gold nanoparticles damaged bacterial cell walls, disrupted metabolism and produced reactive oxygen species. Higher metal ion concentrations enhanced antibacterial efficiency, with gram-positive bacteria requiring higher concentrations than gram-negative bacteria. These findings offer insights into minimum inhibition concentration and minimum bactericidal concentration determination. This research contributes to understanding green synthesis and the potential applications of plant extract-mediated nanoparticles in antibacterial treatments, emphasizing the importance of nanoparticle size and concentration in targeting bacteria.
Cite this article:
Rory A. Hutagalung, Giovani, Kristina Simanjuntak, Cut Fauziah, Hany Yusmaini, Meiskha Bahar, Niniek Hardini, Siti Nurbaya, Vivitri D. Prasasty. Green Synthesis of Gold Nanoparticles with Manilkara zapota Leaf Extract and Its Application as Antibacterial Agent. Research Journal of Pharmacy and Technology. 2024; 17(11):5509-4. doi: 10.52711/0974-360X.2024.00842
Cite(Electronic):
Rory A. Hutagalung, Giovani, Kristina Simanjuntak, Cut Fauziah, Hany Yusmaini, Meiskha Bahar, Niniek Hardini, Siti Nurbaya, Vivitri D. Prasasty. Green Synthesis of Gold Nanoparticles with Manilkara zapota Leaf Extract and Its Application as Antibacterial Agent. Research Journal of Pharmacy and Technology. 2024; 17(11):5509-4. doi: 10.52711/0974-360X.2024.00842 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-11-50
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