ABSTRACT:
Aim: To investigate the anti-diabetic and wound healing activity of polyherbal formulation sarkaraikolli on rats. Materials and Method: In this model, animals were administered with test and standard samples by oral route. Frequently blood samples were taken and examined for blood glucose levels, which were assessed using a glucometer. The animals were sacrificed by 2 hours on the 21st day after the treatment by cervical dislocation and biochemical studies were performed. The blood samples were collected and serum was separated by centrifugation at 3000 rpm for 15 minutes after a retro-orbital puncture. Different procedures were performed for the determination of liver enzyme tests. In the model of anti-diabetic animals were evenly divided into 5 groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4, and 5 were the treatment groups which were simultaneously treated with standard, 250 and 500 mg/kg extract respectively after glucose loading. Results: Sarkaraikolli possesses significant anti-diabetic, and wound healing activity when compared to the conventional medicine like Glibenclamide. Significant anti-diabetic action is visible due to lower blood glucose levels and maintenance of steady body weights. Sarkaraikolli wound healing activity is demonstrated by higher wound healing activity as compared to the standard medication.