Author(s):
Basri A. Gani, Subhaini Jakfar, Pitu Wulandari, Fitri Yunita Batubara, Kemala Hayati, Rike Rayanti, Jeti Erawati, Viona Diansari
Email(s):
basriunoe@usk.ac.id
DOI:
10.52711/0974-360X.2024.00812 
Address:
Basri A. Gani1*, Subhaini Jakfar2, Pitu Wulandari3, Fitri Yunita Batubara4, Kemala Hayati5, Rike Rayanti6, Jeti Erawati7, Viona Diansari2
1Department of Oral Biology, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
2Department of Dental Material, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
3Department of Periodontics, Dentistry Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
4Department of Conservative Dentistry, Dentistry Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
5Department of Oral Radiology, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia.
6Department Dentistry, Hospital of Bhayangkara Mobile Brigade, Indonesian National Police, Depok, Indonesia.
7Department of Periodontics, Dentistry Faculty, Universitas Trisakti, Jakarta, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 11,
Year - 2024
ABSTRACT:
Healing of gingival wounds after periodontal surgery is a crucial aspect that influences the success of the procedure and patient comfort.Chitosan films, with their biocompatibility and biodegradability properties, have been explored as a drug delivery medium to accelerate tissue regeneration.This study aims to evaluate the effectiveness of chitosan film as a stimulant for gingival wound healing by increasing local drug delivery. Blood smear preparations assessed the immune cells, andHematoxylin and Eosin staining evaluated the number of fibroblast cells, osteoblast cells, and osteoclasts.Meanwhile, the Il-1ß titers were assessed using the ELISA assay.Film chitosan 30% has a good effect on maintaining immune cell responses, increasing the number of fibroblast cells, preventing gingival epithelial cell toxicity, increasing osteoblast cell function, and reducing alveolar bone osteoclasts.In addition, Its film 30% can reduce the response of IL-1ß and post-gingival trauma.This study proves that chitosan film as a drug delivery agent can catalyze periodontal therapy, accelerating gingival healing.Thus, chitosan films offer a promising, innovative therapeutic strategy for application in periodontal surgery.
Cite this article:
Basri A. Gani, Subhaini Jakfar, Pitu Wulandari, Fitri Yunita Batubara, Kemala Hayati, Rike Rayanti, Jeti Erawati, Viona Diansari. Role Chitosan Film as a Catalyst for Rapid Gingival Healing: An Innovation in Periodontal Therapy. Research Journal of Pharmacy and Technology. 2024; 17(11):5305-0. doi: 10.52711/0974-360X.2024.00812
Cite(Electronic):
Basri A. Gani, Subhaini Jakfar, Pitu Wulandari, Fitri Yunita Batubara, Kemala Hayati, Rike Rayanti, Jeti Erawati, Viona Diansari. Role Chitosan Film as a Catalyst for Rapid Gingival Healing: An Innovation in Periodontal Therapy. Research Journal of Pharmacy and Technology. 2024; 17(11):5305-0. doi: 10.52711/0974-360X.2024.00812 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-11-20
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