Author(s): Baraa Daghman, Nisrin Kaddar, Mohammed Ayyed Najm, Hala Barakat

Email(s): baraadaghman@gmail.com

DOI: 10.52711/0974-360X.2024.00720   

Address: Baraa Daghman1, Nisrin Kaddar2, Mohammed Ayyed Najm3, Hala Barakat4
1MD, Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
2PhD, Department of Pharmaceutical, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
3Assistant Professor, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
4PhD, Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Al-Sham Private University (ASPU), Lattakia, Syria.
*Corresponding Author

Published In:   Volume - 17,      Issue - 10,     Year - 2024


ABSTRACT:
Various geometrical shapes of paracetamol tablets are available, which play an important effect on the speed and quantity of drug release and swallow ability. Patients with swallowing disorders experience difficulties taking large dose (1000mg), which may lead to take two smaller tablets 500mg. This study purposes to investigate the impact of doubling dose and different geometrics on drug release, depending on dissolution test and surface area to volume ratio (SA/V). First, all the studied companies were confirmed to the required constitutional specifications. Then, the dimensions of different shapes of tablets and SA/V ratio were calculated by using Solid Works program. Finally, the dissolution test was performed in a medium of phosphate buffer (pH=5.8) for 30 minutes. All tablets were accepted in term of uniformity of content and weight and showed acceptable friability, with suitable hardness and the disintegration time was less than 30 minutes. After half an hour of beginning the dissolution test, over 80% of the paracetamol from all the tablets examined was found to have been released. The release rates were approximately constant for the various shapes of tablets with the same rate of SA/V. Drug release from two tablets of 500mg was faster than that from one tablet of 1000mg, this offers a therapeutic benefit to achieve the analgesic effect more quickly.


Cite this article:
Baraa Daghman, Nisrin Kaddar, Mohammed Ayyed Najm, Hala Barakat. Comparison of double dose of Paracetamol tablets 500mg with one Paracetamol tablet 1000mg. Research Journal of Pharmacy and Technology. 2024; 17(10):4671-4676. doi: 10.52711/0974-360X.2024.00720

Cite(Electronic):
Baraa Daghman, Nisrin Kaddar, Mohammed Ayyed Najm, Hala Barakat. Comparison of double dose of Paracetamol tablets 500mg with one Paracetamol tablet 1000mg. Research Journal of Pharmacy and Technology. 2024; 17(10):4671-4676. doi: 10.52711/0974-360X.2024.00720   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-10-5


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