Author(s):
Temurbek Khajibaev, Feruza Egamova, Dilnoza Mutalova, Sevar Yusupova, Ravshanjon Khalilov, Shakhzod Jumaniyozov, Tamilla Abduraxmanova
Email(s):
hajibaev84@mail.ru
DOI:
10.52711/0974-360X.2024.00742
Address:
Temurbek Khajibaev*, Feruza Egamova, Dilnoza Mutalova, Sevar Yusupova, Ravshanjon Khalilov, Shakhzod Jumaniyozov, Tamilla Abduraxmanova
Institute of the Chemistry of Plant Substances Named after Acad. S.Yu. Yunusov of the Academy of the Sciences Republic of Uzbekistan, St. Mirzo Ulugbeka, 77, Tashkent, 100170 (Uzbekistan).
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
5 samples of dry extract were obtained from the processing waste of the aerial part of Tribulus terrestris L., from the meal after extraction with 70% ethanol. Based on pharmacological studies, it was established that dry extract from Tribulus terrestris meal, containing 22% polysaccharides and 31.3% of the total phenolic compounds, exhibits a hypoazotemic effect, which has a positive effect on kidney function. In the experimental model of acute kidney failure caused by the introduction of a 50% aqueous solution of glycerol and acute kidney pathology caused by iodine tincture, Triburenal substance obtained from Tribulus terrestris meal has a significant hypoazotemic action. This prevents a sharp increase in the end products of nitrogen metabolism in the blood serum of animals and reduces these indicators more than the reference drug Cynaroside. The urea content in the blood serum of rats receiving Triburenal on the third day of pathology, the difference from the control was 52.0%. Similar changes were noted in the creatinine content in the blood serum; the difference with the control was 49.0%. Regarding the degree of reduction of urea and creatinine in the blood, the Triburenal substance from Tribulus terrestris meal is superior to the hypoazotemic drug Cynaroside. A technological scheme has been proposed for the production of a pharmaceutical substance in the form of a dry extract with a hypoazotemic action from Tribulus terrestris meal with a final product yield of 5.65% by weight of the raw material. The technology is as follows: after extraction of the aerial part of Tribulus terrestris with 70% ethanol, the meal is dried in a drying apparatus with forced air ventilation with a layer of plant raw material on a drying baking tray of 20 mm thick, supplying air at a temperature of 70°C at a speed of 15 m/s for 5 hours, the dried meal is extracted with 40% ethanol at a temperature of 60°C four times at a hydro modulus of 1:18, infusing for 3 hours, the combined extract is concentrated to a content of 15% dry weight and dried. The results obtained make it possible to use the aerial part of Tribulus terrestris rationally.
Cite this article:
Temurbek Khajibaev, Feruza Egamova, Dilnoza Mutalova, Sevar Yusupova, Ravshanjon Khalilov, Shakhzod Jumaniyozov, Tamilla Abduraxmanova. Hypoazotemic action of dry extracts from the waste of Tribulus terrestris. Research Journal of Pharmacy and Technology. 2024; 17(10):4826-2. doi: 10.52711/0974-360X.2024.00742
Cite(Electronic):
Temurbek Khajibaev, Feruza Egamova, Dilnoza Mutalova, Sevar Yusupova, Ravshanjon Khalilov, Shakhzod Jumaniyozov, Tamilla Abduraxmanova. Hypoazotemic action of dry extracts from the waste of Tribulus terrestris. Research Journal of Pharmacy and Technology. 2024; 17(10):4826-2. doi: 10.52711/0974-360X.2024.00742 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-10-27
REFERENCES:
1. Mamatkhanov AU, Khalilov RM, Mamatkhanova MA. Complex processing of Rhaponticum carthamoides rhizomes with roots to produce ecdisten substance, total flavonoids, and lipid concentrate. Pharmaceutical Chemistry Journal. 2021; 54(10): 1040-1044. doi.org/10.1007/s11094-021-02325-z
2. Mamatkhanov AU, Khajibaev TA, Khalilov RM. Technology of obtaining the sum of iridoids from the waste processing the aerial part of Ajuga turkestanica. Khimiya Rastitel'nogo Syr'ya. 2023; 3: 293–302. doi.org/10.14258/jcprm.20230311829.
3. Khalilov RM, et al. Component composition of lipid-containing waste from processing aerial parts of Ferula tenuisecta and Ferula kuhistanica and development of an oil composition with wound-healing action. Pharmaceutical Chemistry Journal. 2023; 57(5): 683-687. doi.org/10.1007/s11094-023-02938-6
4. Grigorova S, et al. Effect of Tribulus terrestris extract on semen quality and serum total cholesterol content in white Plymouth rock-mini cocks. Biotechnology in Animal Husbandry. 2008; 24(3-4): 139-146. doi.org/10.2298/BAH0804139G
5. Mamdouh NS, et al. Pharmacognostical Studies on Stem of Tribulus terrestris L. Research J. Pharmacognosy and Phytochemistry. 2013; 5(4): 171-177.
6. Mamdouh NS, et al. Pharmacognostical Studies on Leaf of Tribulus terrestris L. Research J. Pharmacognosy and Phytochemistry 2012; 4(6): 303-309.
7. Mamdouh NS, et al. Tribulin, a New Steroidal Saponin from the Aerial parts of Tribulus terrestris. Research J. Pharmacognosy and Phytochemistry. 2012; 4(5): 237-239.
8. Toyjonov K, Nigmatullaev BA, Sagdullaev ShSh. Etymological dictionary of Latin names of medicinal plants of Uzbekistan. Tashkent. 2016.
9. Zhurba OV, Dmitriev MYa. Medicinal, Poisonous and Harmful Plants. Moscow. 2008.
10. Burda NYe, et al. The element composition study of thick extract from Tribulus terrestris L. Herb. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016; 7(6): 2200-2202.
11. Xu Y, et al. A new furostanol glycoside from Tribulus terrestris. Molecules. 2010; 15(2): 613-618. doi.org/10.3390/molecules15020613
12. Khudenko PE, et al. Flavonoids in the grass of Tribulus terrestris L. Pharmacy and Pharmacology. 2015; 2(9): 18-23. doi.org/10.19163/2307-9266-2015-3-2(9)-18-23
13. Hammoda HM, et al. Chemical constituents from Tribulus terrestris and screening of their antioxidant activity. Phytochemistry. 2013; 92: 153-159. doi.org/10.1016/j.phytochem.2013.04.005
14. Noori M, Dehshiri MM, Zolfaghari MR. Tribulus Terrestris L. (Zygophyllaceae) Flavonoid Compounds. International Journal of Modern Botany. 2012; 2(3): 35-39. doi.org/10.5923/j.ijmb.20120203.01
15. Madhavi T, et al. A Phytochemical Review on Tribulus terrestris Linn. Research J. Pharmacology and Pharmacodynamics. 2011; 3(5): 218-222.
16. Madhavi T, et al. Isolation of Tiliroside from Tribulus terrestris. Research J. Pharmacognosy and Phytochemistry. 2011; 3(6): 281-285.
17. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sciences 2003; 73(23): 2963-2971. doi.org/10.1016/j.lfs.2003.04.002
18. Chhatre S, et al. Phytopharmacological overview of Tribulus terrestris. Pharmacognosy Reviews. 2014; 8(15): 45-51. doi.org/10.4103/0973-7847.125530
19. Heidari MR, et al. The Analgesic Effect of Tribulus terrestris Extract and Comparison of Gastric Ulcerogenicity of the Extract with Indomethacine in Animal Experiments. Annals of the New York Academy of Sciences. 2007; 1095(1): 418-427. doi.org/10.1196/annals.1397.045
20. Ojha SK, et al. Chronic Administration of Tribulus terrestris Linn. extracts improve cardiac function and Attenuates Myocardial Infarction in Rats. International Journal of Pharmacology. 2008; 4(1): 1-10. doi.org/10.3923 / ijp.2008.1.10
21. Sudhanshu KM, et al. Experimental studies on the Renal Protective effect of Gokshura (Tribulus terrestris Linn) and Varuna (Crataeva nurvala Buch-Ham). Research J. Pharmacology and Pharmacodynamics. 2016; 8(2): 75-82. doi: 10.5958/2321-5836.2016.00014.8
22. Latifa NA, et al. Evaluation of Antibacterial and Antioxidant activities of Tribulus terrestris L. Fruits. Research Journal of Pharmacy and Technology. 2021; 14(1): 331-336. doi: 10.5958/0974-360X.2021.00061.5
23. Dileep SB, et al. Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2021; 14(4): 1945-2. doi: 10.52711/0974-360X.2021.00344
24. Latifa NA, et al. Evaluation of Anticancer Activity of Withania somnifera L. and Tribulus terrestris L. on Human Breast Cancer Cells In vitro. Research Journal of Pharmacy and Technology 2023; 16(7): 3079-2. doi: 10.52711/0974-360X.2023.00506
25. Khristich TN, et al. Tribestan helps athletes going in for power sports. Bukovinian Medical Herald. 2011; 15(2-58) 126-129.
26. Khajibaev TA, Khalilov RM. The process optimization of furostanol saponins extraction from the aerial part of Tribulus Terrestris. International Journal of Scientific Research in Chemical Sciences. 2023; 10(6): 1-7.
27. Hajibaev TA, Ibragimov TF, Khalilov RM. Optimal conditions for cleaning and drying furostanol saponins from Tribulus terrestris. Khimiya Rastitel'nogo Syr'ya. 2023; 2: 327–333. doi.org/10.14258/jcprm.20230211444
28. Mamatkhanova MA, et al. Technology for cynaroside production from the aerial part of Ferula varia and evaluation of its hypoazotemic activity. Pharmaceutical Chemistry Journal, 2009; 43(3): 160-162. doi.org/10.1007/s11094-009-0262-7
29. Guliaev VG, Ivanov I.I, Guliaeva SF. The hypoazotemic and diuretic action of lespeflan in acute kidney failure. Urol Nefrol (Mosk). 1993; 4: 32-34.
30. Borisova IV, Shtrygol SYu. Renal and neuroprotective effects of perftoran on a model of toxic kidney damage in rats. Russian Biomedical Journal. 2004; 5(36): 136-139.
31. Valdivielso JM, et al. Role of glomerular nitric oxide in glycerol-induced acute renal failure. Canadian Journal of Physiology and Pharmacology. 2000; 78(6): 476-482. doi.org/10.1139/y00-012
32. Sokolova VE. On the hypoazotemic effect of flavonoids. Pharmacology and toxicology. Republican interdepartmental collection. 1975; 10:62-66.
33. Kotenko LD, et al. Standardization of the herb Ferula varia. Khimiya Rastitel'nogo Syr'ya. 2009; 4: 151–154.
34. Kakhramanova SD, Bokov DO, Samylina IA. Quantification of polysaccharides in medicinal plant raw materials. Farmatsiya, 2020; 69(8): 5–12. doi.org/10/29296/25419218-2020-08-01.
35. Nikolaeva TN, Lapshin PV, Zagoskina NV. Method for determining the total content of phenolic compounds in plant extracts with folindenis reagent and folin-chocalteu reagent: modification and comparison. Khimija rastitel'nogo syr'ja. 2021; 2:291–299. doi.org/10.14258/jcprm.2021028250
36. Sonia, Singh Sumitra. Tribulus terrestris L. fruits: An extensive Pharmacognostical and Phytochemical Quality Assesment using UV-spectrophotometer. Research Journal of Pharmacy and Technology. 2022; 15(12): 5431-5. doi.org/10.52711/0974-360X.2022.00915