Author(s):
Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika
Email(s):
aishwarya.111188@gmail.com , aishwaryauday4@gmail.com
DOI:
10.52711/0974-360X.2024.00072 
Address:
Iswarya Obilineni1, Srikala Kamireddy2, A V S Ravi Sai Nadh1, Supriya Chatla3, Vadivelan Ramachandran4, Kanuri Bhuvaneswari5, Padavala Harika5
1Assistant Professors, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada
2Assistant Professor, Nirmala College of Pharmacy, Atmakur, Guntur
3Associate Professor, Nirmala College of Pharmacy, Atmakur, Guntur
4Professor, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgris, Tamil Nadu, India.
5B. Pharmacy Students, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2024
ABSTRACT:
The aim of this work was to develop Alendronate mucoadhesive buccal tablets. Buccal tablets of Alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Sodium alginate, Ethyl cellulose and Carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailability of Alendronate buccal tablets. In present study, an attempt was made to design mucoadhesive buccal tablets containing Alendronate, Sodium alginate, Ethyl cellulose and Carbopol using as polymers. The tablets were prepared by direct compression method. The formulations were evaluated for hardness, thickness, friability, weight variation, drug content estimation, surface pH determination, swelling index, in vitro drug release. The obtained results of various evaluation parameters are described in post compression studies. The results of in vitro release study were in full support of swelling study. In vitro release data of optimized formula F11 fitted into various release kinetic models to study the release mechanism. All the prepared tablets were stable at different temperature and shows good mucoadhesive properties.
Cite this article:
Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika. Formulation, Development and In-vitro Evaluation of Alendronate Buccal Tablets. Research J. Pharmacy and Technolgy. 2024; 17(1):460-464. doi: 10.52711/0974-360X.2024.00072
Cite(Electronic):
Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika. Formulation, Development and In-vitro Evaluation of Alendronate Buccal Tablets. Research J. Pharmacy and Technolgy. 2024; 17(1):460-464. doi: 10.52711/0974-360X.2024.00072 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-72
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