Author(s): Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika

Email(s): aishwarya.111188@gmail.com , aishwaryauday4@gmail.com

DOI: 10.52711/0974-360X.2024.00072   

Address: Iswarya Obilineni1, Srikala Kamireddy2, A V S Ravi Sai Nadh1, Supriya Chatla3, Vadivelan Ramachandran4, Kanuri Bhuvaneswari5, Padavala Harika5
1Assistant Professors, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada
2Assistant Professor, Nirmala College of Pharmacy, Atmakur, Guntur
3Associate Professor, Nirmala College of Pharmacy, Atmakur, Guntur
4Professor, Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgris, Tamil Nadu, India.
5B. Pharmacy Students, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
The aim of this work was to develop Alendronate mucoadhesive buccal tablets. Buccal tablets of Alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Sodium alginate, Ethyl cellulose and Carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailability of Alendronate buccal tablets. In present study, an attempt was made to design mucoadhesive buccal tablets containing Alendronate, Sodium alginate, Ethyl cellulose and Carbopol using as polymers. The tablets were prepared by direct compression method. The formulations were evaluated for hardness, thickness, friability, weight variation, drug content estimation, surface pH determination, swelling index, in vitro drug release. The obtained results of various evaluation parameters are described in post compression studies. The results of in vitro release study were in full support of swelling study. In vitro release data of optimized formula F11 fitted into various release kinetic models to study the release mechanism. All the prepared tablets were stable at different temperature and shows good mucoadhesive properties.


Cite this article:
Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika. Formulation, Development and In-vitro Evaluation of Alendronate Buccal Tablets. Research J. Pharmacy and Technolgy. 2024; 17(1):460-464. doi: 10.52711/0974-360X.2024.00072

Cite(Electronic):
Iswarya Obilineni, Srikala Kamireddy, A V S Ravi Sai Nadh, Supriya Chatla, Vadivelan Ramachandran, Kanuri Bhuvaneswari, Padavala Harika. Formulation, Development and In-vitro Evaluation of Alendronate Buccal Tablets. Research J. Pharmacy and Technolgy. 2024; 17(1):460-464. doi: 10.52711/0974-360X.2024.00072   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-72


References:

1.     Sozen T. Lale O. Nursel CB. An overview and management of osteoporosis. EurJ of Rheumatology, 2017 Mar; 4(1):46-56.

2.     Ibrahim A. Hassan Z. Osteoporosis: current concepts, Joints. 2018 Jun; 6 (2): 122-127.

3.     Tarantino U. Feola M. Saturnino L. Rao C. Efficacy of Alendronate in the management of fragility fractures. Clinical cases in Mineral and Bone Metabolism. 2010; 7(3): 166.

4.     PrinslooPJJ. Hosking D. Alendronate sodium in the management of Osteoporosis, Therapeutic and Clinical Risk Management. 2006; 2(3):235-249.

5.     Jacques PB. Kerneth SD. Wojciech PO. Karen AB. Jonathan DA. A Critical review of Brand and Generic alendronate for the treatment of Osteoporosis. Springerplus, 2013; 2 (1): 550

6.     Adilakshmi D. Abdul SM. Nuha R. Devi KU. Pasupuleti C. simultaneous formulation, estimation and evaluation of Allopurinol sustained release tablets using various suitable excipients. Asian J. Pharm. Ana. 2016; 6(3): 155-156.

7.     Sandhya Raj S. Sundramoorthy K. Vetrichelvan T. Preparation and characterisation of Valsartan loaded alginate mucoadhesive microcapsules. Research Journal of Pharmaceutical Dosage Forms and Technology 2011; 3(1): 07-11.

8.     Surender V. Mahima K. Aruna R. An Overview on Buccal Drug Delivery System. International Journal of Pharmaceutical Sciences and Research, 8232.

9.     Shivani C. Pravin K. Vinay P. Mahendra SA. Mucoadhesive in situ nasal gel: A promising approach. Asian J Res. Pharm. Sci. 2021; 11(1): 58-64

10.  Ganesan V. Nilesh PT. Nitin SB. Durgesh RD. Raju RT. Design and Evaluation of Mucoadhesive Tablets of Lorsatan  Potassium. Research J Pharma, Dosage forms and Tech. 2009; 1(2): 139-142.

11.  Smita SA. Vaishali D. Sangale. Ravindra BS. Mucoadhesive formulations for buccal mucosa. Asian J. Res. Pharm. Sci. 2016; 6(3): 146-152.

12.  Chonkar AD. Bhagawati S. Udupa N. An Overview on Fat Dissolving Oral Films. Asian Journal of Pharmacy and Technology.  2015; 5(3).

13.  Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum. Asian J. Res. Pharm. Sci. 2014;  4(2): 77-82.

14.  Venkataswamy M. Arul B. Keerthi A. Dinesh MS. Vanitha K. Ramesh A. Preparation and Evaluation of a Mucoadhesive polymer from the extract of seeds of Annona squamosa Linn. Asian J. Res. Pharm. Sci. 2017; 7(3):149-156

15.  Aishwarya MNL. RajVP. Debnath S. Babu MN. A Review on Buccal Drug Delivery System, Research Journal of Pharmaceutical Dosage forms and Technology. 2017; 9(3).

16.  Monali S. Dattatrey S. Ravindra S. Mucoadhesive Buccal Drug Delivery System: History and Recent Developments. Asian Journal of Pharmaceutical and Clinical Research. 2016; 9(6).

17.  Manmohan SJ. Abhishek KS. Gastro-retentive mucoadhesive nanopaticle for sustained drug delivery system. Asian J. Pharm. Res. 2014; 4(2): 55-64.

18.  Patel M. Karigar A. Savaliya P. Ramana MV. Dubal A. Buccal Drug Delivery System: the current interest. International Research Journal of Pharmacy. 2011.

19.  Puratchikody A. Prasanth VV. Mathew T. Ashok KB. Buccal Drug Delivery: Past, Present and Future – A Review. International Journal of Drug Delivery. 2011; 3: 171-184.

20.  Debijit B. Sampath KP. Lokesh D. Buccal Drug Delivery System – A novel drug delivery system. Research Journal of Science and Technology. 2016; 8(2).

21.  Monali S. Dattatrey S. Ravindra S. Mucoadhesive Buccal Drug Delivery System: History and Recent Developments. Asian Journal of Pharmaceutical and Clinical Research. 2016;9(6).

22.  Gupta SK. Singhvi JK. Shirsat M. Karwani G. Agarwal A. Aditi A. Buccal adhesive Drug delivery system: a review. Asian Journal of Biochemical and Pharmaceutical Research, 2011; 1(2).

23.  Chinna RP. Chaitanya KSC. Madhusudhan YR. A Review on bioadhesive buccal drug delivery system: Current status of formulation and evaluation methods. DARU Journal of Pharmaceutical Sciences. 2011; 19 (6): 385-403.

24.  Parth SP. Ashish M. Parmar NS. Doshi HV. Patel RR. Patel CN. Buccal Drug Delivery System: A Review. International Journal of Drug Development and Research.  2013.

25.  Surender V. Mahima K. Aruna R. An Overview on Buccal Drug Delivery System. International Journal of Pharmaceutical Sciences and Research. 8232.

26.  Rajesh M. Kishor D. Utpal R. Shripal A. A review on study of buccal drug delivery system, Innovative Systems Design and Engineering. 2(3).

27.  Pawar RR. Raut DB. Karde VK. Wadikar JC. Jadhav AS. Chintale AG. Mucoadhesive buccal drug delivery system: A Review, Research Journal of Pharmacy and Technology. 2013; 6(5).

28.  Harikrishnan V. Madhusudhan S. Santhiagu A. Evaluation of a novel, natural badam gum as a sustained release and mucoadhesive component of tizanidine HCl buccal tablets. Asian j. Pharm. Tech. 2015; 5(2): 71-78. Doi: 10.5958/2231-5713.2015.00012.4

29.  Gupta S. Patra S. Akber SA. Formulation development and in vitro evaluation of alendronate buccal tablets. JDDT. 9(4-s):363-9.

30.  Krishna Reddy Y. Juveria T. Formulation and Evaluation of Bioadhesive buccal drug delivery of Sumatriptan succinate tablets. Asian Journal of Pharmaceutical Research. 2020;10(2).

31.  Nisreen H, Development and evaluation of buccal adhesive tablet of anti emetic agent ondasetron. AAPS Pharmscitech. 2009; 10(4): 1085-1092.

 

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