Author(s): Ardina Purnama Tirta, Imas Solihat, Achmad Nandang Roziafanto, Nurhasanah, Ratnawati L Djanis, Inda Mapiliandari

Email(s): imaskhairani@gmail.com

DOI: 10.52711/0974-360X.2024.00061   

Address: Ardina Purnama Tirta1, Imas Solihat2*, Achmad Nandang Roziafanto2, Nurhasanah3, Ratnawati L Djanis4, Inda Mapiliandari1
1Department of Chemical Analysis, Politeknik AKA Bogor, Jalan Pangeran Sogiri, Tanah Baru, Bogor 16154, Indonesia.
2Department of Food Nanotechnology, Politeknik AKA Bogor, Jalan Pangeran Sogiri, Tanah Baru, Bogor 16154, Indonesia.
3Department of Quality Assurance of Food Industry, Politeknik AKA Bogor, Jalan Pangeran Sogiri, Tanah Baru, Bogor 16154, Indonesia.
4Department of Industrial Waste Treatment, Politeknik AKA Bogor, Jalan Pangeran Sogiri, Tanah Baru, Bogor 16154, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
A study has been conducted on the phytochemical profile and pharmacological activity of Gedi (Abelmoschus manihot (L.) Medik) using a multistage maceration method. The results of the phytochemical screening test showed that the crude extract of Gedi leaves gave a positive reaction to the presence of alkaloids, tannins, phenols, flavonoids, unsaturated steroids and saponins. The total phenolic analysis showed that the total phenolic concentrations of Gedi leaf extracts in methanol, ethyl acetate, and hexane extracts were 1.70, 1.44, and 0.85mg GAE/g extract, respectively. The results of the antioxidant activity assays obtained an IC50 value for methanol, ethyl acetate, and hexane extracts of Gedi leaves, which were 40.77, 155.50, and 25.84mg/L, respectively. The antimicrobial activity results showed that all three Gedi leaf extracts had activity in inhibiting microbial growth. The inhibitory values for methanol, ethyl acetate, and hexane extracts of Gedi leaves were 7.0, 13.5, and 9.5mm, respectively, for Escherichia coli, and 21.5, 15.0, and 13.0mm, respectively, for Bacillus. The toxicity test results showed that the LC50 values of Gedi leaf extracts for methanol, ethyl acetate, and hexane extracts were 500 ppm, 736ppm, and 2249ppm, respectively.


Cite this article:
Ardina Purnama Tirta, Imas Solihat, Achmad Nandang Roziafanto, Nurhasanah, Ratnawati L Djanis, Inda Mapiliandari. Multi-Step Maceration Extraction and Pharmacological Evaluation of Abelmoschus manihot (L.) Medik. Research Journal of Pharmacy and Technology. 2024; 17(1):389-5. doi: 10.52711/0974-360X.2024.00061

Cite(Electronic):
Ardina Purnama Tirta, Imas Solihat, Achmad Nandang Roziafanto, Nurhasanah, Ratnawati L Djanis, Inda Mapiliandari. Multi-Step Maceration Extraction and Pharmacological Evaluation of Abelmoschus manihot (L.) Medik. Research Journal of Pharmacy and Technology. 2024; 17(1):389-5. doi: 10.52711/0974-360X.2024.00061   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-61


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