Author(s):
Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari
Email(s):
fahmipomo@gmail.com
DOI:
10.52711/0974-360X.2024.00059 
Address:
Supomo Supomo1*, Eka Siswanto Syamsul1, Hayatus Saadah1, Kintoko Kintoko2, Hardi Astuti Witasari2
1Departement of Pharmaceutical Biology, Departement of Pharmacology, Departement of Pharmaceutical Technology Sekolah Tinggi Ilmu Kesehatan Samarinda, East Kalimantan, Indonesia.
2Departement of Pharmaceutical Biology, Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2024
ABSTRACT:
The Akar kuning (Fibraurea tinctoria Lour) is a well-known plant for its potential for the treatment of liver damage and hyperglycemia. However, the main constituent responsible for the anti-diabetic effect is unknown. This study was conducted to investigate the effect of administration of Fibraurea tinctoria Lour ethanol extract on the blood sugar levels in alloxan-induced diabetic male albino rats. All animals were acclimatized with normal feed, and were subsequently divided into 5groups (3rats/ group). Group 1 (negative control group) was given 0.3% NaCMC; Groups 2, 3, and 4 (treatment groups), were given 50, 100, and 200mg/kg BW of Fibraurea tinctoria Lour ethanol extract, respectively once daily for 15 days, while Group 5(positive control group) received 0.65mg/kg BW glibenclamide. Before the treatments, the rats were induced intraperitoneally with 175mg/kg BW alloxan monohydrate. The blood glucose levels were observed every five days. The results showed that the ethanol extract at the doses of 50, 100, and 200mg/kg BW caused a significant decrease (p <0.05) in the blood glucose levels compared to the negative control group. Also, the highest decrease in the blood glucose level was observed in the 100mg/kg BW treatment group. The findings from this study indicate that the ethanol extract of Fibraurea tinctoria Lour has an antidiabetic effect and the 100mg/kg BW dose was the most effective in lowering blood glucose levels.
Cite this article:
Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari. Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats. Research Journal of Pharmacy and Technology. 2024; 17(1):379-4. doi: 10.52711/0974-360X.2024.00059
Cite(Electronic):
Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari. Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats. Research Journal of Pharmacy and Technology. 2024; 17(1):379-4. doi: 10.52711/0974-360X.2024.00059 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-59
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