Author(s): Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari

Email(s): fahmipomo@gmail.com

DOI: 10.52711/0974-360X.2024.00059   

Address: Supomo Supomo1*, Eka Siswanto Syamsul1, Hayatus Saadah1, Kintoko Kintoko2, Hardi Astuti Witasari2
1Departement of Pharmaceutical Biology, Departement of Pharmacology, Departement of Pharmaceutical Technology Sekolah Tinggi Ilmu Kesehatan Samarinda, East Kalimantan, Indonesia.
2Departement of Pharmaceutical Biology, Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
The Akar kuning (Fibraurea tinctoria Lour) is a well-known plant for its potential for the treatment of liver damage and hyperglycemia. However, the main constituent responsible for the anti-diabetic effect is unknown. This study was conducted to investigate the effect of administration of Fibraurea tinctoria Lour ethanol extract on the blood sugar levels in alloxan-induced diabetic male albino rats. All animals were acclimatized with normal feed, and were subsequently divided into 5groups (3rats/ group). Group 1 (negative control group) was given 0.3% NaCMC; Groups 2, 3, and 4 (treatment groups), were given 50, 100, and 200mg/kg BW of Fibraurea tinctoria Lour ethanol extract, respectively once daily for 15 days, while Group 5(positive control group) received 0.65mg/kg BW glibenclamide. Before the treatments, the rats were induced intraperitoneally with 175mg/kg BW alloxan monohydrate. The blood glucose levels were observed every five days. The results showed that the ethanol extract at the doses of 50, 100, and 200mg/kg BW caused a significant decrease (p <0.05) in the blood glucose levels compared to the negative control group. Also, the highest decrease in the blood glucose level was observed in the 100mg/kg BW treatment group. The findings from this study indicate that the ethanol extract of Fibraurea tinctoria Lour has an antidiabetic effect and the 100mg/kg BW dose was the most effective in lowering blood glucose levels.


Cite this article:
Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari. Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats. Research Journal of Pharmacy and Technology. 2024; 17(1):379-4. doi: 10.52711/0974-360X.2024.00059

Cite(Electronic):
Supomo Supomo, Eka Siswanto Syamsul, Hayatus Saadah, Kintoko Kintoko, Hardi Astuti Witasari. Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats. Research Journal of Pharmacy and Technology. 2024; 17(1):379-4. doi: 10.52711/0974-360X.2024.00059   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-59


REFERENCES:
1.    Belayneh YM, Birru EM. Antidiabetic activities of hydromethanolic leaf extract of Calpurnia aurea (Ait.) Benth. subspecies aurea (Fabaceae) in mice. Hindawi Evidence-Based Complementary and Alternative Medicine. 2018; 1: 1-9.http://doi: 10.1155/2018/3509073.
2.    International Diabetes Federation. IDF Diabetes Atlas, Ninth Edition. Brussels, Belgium: International Diabetes Federation. 2019.
3.    Sharma US and Kumar A. Antidiabetic effects of Rubus ellipticus fruit extracts in alloxan induced diabetic rats. J Diabetol. 2011; 2(4): 1-6.
4.    Selvaraja MAP, Ndyeabura AW, Akowuah GA, Okechukwu PN. Antidiabetic activity of crude stem extracts of Coscinium fenestratum on streptozotocin-induced Type-2 diabetic rats. Asian J Pharmaceut Clin Res. 2011; 4(4): 47-51.
5.    Noorcahyati. Plants Efficacious Drugs Ethnic Native Kalimantan. Research Institute for Natural Resources Conservation Technology. Samboja. 2015; 2: 59.
6.    Sulistiarini R, Soemardji A, Elfahmi A, Iwo MI. Pharmacological activities of three kinds "Kayu kuning": Arcangelisia flava. Fibraurea tinctoria and Coscinium fenestratum: A short review. J Trop Pharm Chem. 2020; 5(2): 150-156. https://doi.org/10.25026/jtpc.v5i2
7.    Alara OR and Hamid NA. Antidiabetic activity and mineral elements evaluation of Vernonia amygdalina leaves obtained from Malaysia. J Res Pharm. 2019; 23(3): 514-521.http://doi.org/10.12991/jrp.2019.158
8.    Ahmed T, Gilani AUH, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM. Berberine and neurodegeneration: A review of literature. Pharmacol Rep. 2015; 67(5): 970–979. doi: 10.1016/j.pharep.2015.03.002.
9.    Raza A, Aslam B, Naseer MU, Ali A, Majeed W, Hassan SU. Antitumor activity of berberine against breast cancer: A review. Int Res J Pharm. 2015; 6(2): 81–85.http://doi.10.7879/2230-8407.06219
1.    10.    Fiana N, and Oktaria D. The effect of saponin content in the flesh of God's crown fruit   (Phaleria macrocarpa) on decreased blood glucose levels. J Majority. 2016; 5(4): 128–132.
10.    Fikriah I. Activity of hepatoprotective rod, Fibraure tinctoria Lour in vivo. J. Trop Pharm Chem. 2012; 1(4): 289-296 https://doi.org/10.25026/jtpc.v1i4.39
11.    Qi F, Sun Y, Lv M, Qin F, Cao W, Bi L. Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma. Photochem Photobiol Sci 2019; 18(6): 1596-1605.http://doi: 10.1039/c9pp00040bp://
12.    Rahayu U, Sandri NH, Syilfa H, Sutri D. Antidiabetes Activity test ethanol extract from roots and stems of sekunyit plant (Fibraurea tinctoria Lour). Indon J Pharm. 2015; 7(4): 216-222.
13.    Misra M and Aiman U. Alloxan: An unpredictable drug for diabetes induction. Indian J Pharmacol. 2012; 44(4): 538– 539.http://doi: 10.4103/0253-7613.99348
14.    Lenzen S. The mechanism of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008; 51: 216-226.
15.    Derosa G, Maffioli P, Cicero AFG. Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidence to clinical trials. Expert Opin Bio Therapy. 2012; 12(8): 1113–1124.http://doi: 10.1517/14712598.2012.704014
16.    Singh IP  and Mahajan S. Berberine and its derivatives: A patent review 2009–2012. Expert Opin Therap Patents. 2013; 23(2): 215–231. http://doi: 10.1517/13543776.2013.746314
17.    Vuddanda PR, Chakraborty S, Singh S. Berberine: A potential phytochemical with multispectrum therapeutic activities. Expert Opin Invest Drugs. 2010; 19(10): 1297–1307.http://doi: 10.1517/13543784.2010.517745
18.    Zhang Q, Xiao X, Feng, K. et al. Berberine moderates glucose and lipid metabolism through multipathway mechanism. Evid-Based Complementary and Altern Med. 2011; 1: 1-10.http://doi: 10.1155/2011/924851
19.    Pang B, Zhao LH, Zhou Q, Zhao TY, Wang H, Gu CJ, Tong XL. Application of berberine on treating type 2 diabetes mellitus. Int J Endocrin. 2015; 1: 1-12.http://doi: 10.1155/2015/905749
20.    Wahyudi LD, Ratnadewi A, Siswoyo AI. Potential antioxidant and antidiabetic activities of Kayu Kuning (Arcangelisia Flava). Agric Agricul Sci. 2017; 9: 396–402.https://doi.org/10.1016/j.aaspro.2016.02.155
21.    Supomo, Sa`adah H, Syamsul E, Kintoko S, Witasari HA. Specific parameters and non-specific parameters of yellow root (Fibraurea tinctoria Lour). Ibnu Sina Sci J. 2020; 5(2): 403-412.https://doi.org/10.36387/jiis.v5i2.592
22.    Kurniawati E and Sianturi CY. Benefits of anthill (Myrmecodia pendans) as antidiabetes therapy. Med J Lampung University. 2016; 5(3): 38–42.
23.    Rupesh Gautam and S.C. Sharma. 2012. Effect of Punica granatum Linn. (Peel) on Blood Glucose Level in Normal and Alloxan- Induced Diabetic Rats. Research J. Pharm. and Tech, 5(2): 226-227
24.    Biswajit Sarma, Bhabesh Ch. Goswami. 2018. Evaluation of Hypoglycemic effect of Ethanol extract of Musa paradisiaca unripe fruit pulp on normal and alloxan induced diabetic mice.. Research J. Pharm. and Tech. 11(3): 1048-1052. https://doi:10.5958/0974-360X.2018.00196.8

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available