Author(s):
Yuniati Valentina, Nida Suraya, Leni Lismayanti
Email(s):
valentinayuni2019@gmail.com
DOI:
10.52711/0974-360X.2024.00050 
Address:
Yuniati Valentina1*, Nida Suraya2, Leni Lismayanti2
1Clinical Pathology Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
2Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2024
ABSTRACT:
Coronavirus Disease 2019 (COVID-19) has a clinical spectrum that varies from asymptomatic to death. Cytokine storms cause neutrophilia, lymphopenia, and thrombocytopenia at various levels of COVID-19 severity. These three parameters can be studied as markers of inflammation in the form of ratios. This study aims to discover the correlation between NLR & PLR inflammatory markers in determining the severity of COVID-19.An analytical cross-sectional study was carried out on secondary data from 274 subjects collected from the subject's hematological parameters from first day of admission to Hasan Sadikin Hospital from May-December 2020. The statistical analysis with Spearman test using the SPSS 17.0 program. There are 274 subjectswith non-severe and severe COVID-19 were NLR (3,44 vs 7,17), PLR (182,4 vs 254,4). The r coefficient of NLR and PLR reached 0.308 and 0.198, p-value of < 0.001.In the next phase, days 7-14, lymphocytes decrease significantly. This study found a weak correlation because neutrophilia occurred on the third-seventh day of treatment, while the assessment was performed at first day of admission with clinical symptoms on day 1-3. PLR and NLR have a weak positive correlation with the severity of COVID-19. Therefore, it cannot be utilized independently in determining the severity of COVID-19.
Cite this article:
Yuniati Valentina, Nida Suraya, Leni Lismayanti. Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital. Research Journal of Pharmacy and Technology. 2024; 17(1):323-6. doi: 10.52711/0974-360X.2024.00050
Cite(Electronic):
Yuniati Valentina, Nida Suraya, Leni Lismayanti. Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital. Research Journal of Pharmacy and Technology. 2024; 17(1):323-6. doi: 10.52711/0974-360X.2024.00050 Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-50
REFERENCES:
1. Rahate SK, Bombale MR. Introduction to Covid-19. Res J Sci Tech. 2020; 12(4): 338-345. DOI: 10.5958/2349-2988.2020.00051.0
2. Sanggap IS, Budi SP, Shafira KS, Monika ES. Effect of CRP, IL-6, Leukocytes, NLR on Chronic Periodontitis in Acute Coronary Syndrome. Res J Pharm Technol. 2023; 16(1): 391-8. DOI: 10.52711/0974-360X.2023.00067
3. Samara M, Hussein S, Afraa Z. NLR and PLR as Available and Inexpensive markers for Evaluation of Subclinical Inflammation in patients with Chronic Kidney Disease. Res J Pharm Technol. 2023; 16(1): 187-2. DOI: 10.52711/0974-360X.2023.00035
4. Qu, R, Ling, Y, Zhang, Y-H-Z, et al. Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol. 2020; 92: 1533–1541.
5. Ai-Ping Yang, Jian-ping Liu, Wen-qiang Tao, et al. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 T patients. 2020, https://doi.org/10.1016/j.intimp.2020.106504.
6. Lim, S., Bae, J. H., Kwon, H.-S., & Nauck, M. A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-020-00435-4
7. Liu, Y. et al., 2020. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. Elsevier Ltd. 81(1), pp. e6-e12.
8. Yang M. Cell pyroptosis, a potential pathogenic mech- anism of 2019-nCoV infection. 2020, http://dx.doi.org/ 10.2139/ssrn.3527420.
9. Bonow, RO, Fonarow, GC, O’Gara, PT, et al. Association of coronavirus disease 2019 (COVID-19) with myocardial injury and mortality. JAMA Cardiol 2020; 5: 751.
10. Gasparyan, AY, Ayvazyan, L, Mukanova, U, et al. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med . 2019; 39: 345–357.
11. Lim, S., Bae, J. H., Kwon, H.-S., & Nauck, M. A. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology. 2021; 17(1): 11–30. https://doi.org/10.1038/s41574-020-00435-4
12. Liu, Y. et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. Elsevier Ltd. 2020; 81(1): e6-e12.
13. Ai-Ping Yang, Jian-ping Liu, Wen-qiang Tao, et al. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 T patients. 2020, https://doi.org/10.1016/j.intimp.2020.106504.
14. Qin, C. et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China, Clinical Infectious Disease. 2020; 71 (15); 762-768.
15. Emilia T, Jeremi O, Johan S, Yulanda A. Molecular Docking of Active Compounds from Traditional Medicinal Plants as ACE-2 protein (1R4L) inhibitor in searching for COVID-19 drug. Res J Pharm Technol. 2022; 15(9): 4235-0. DOI: 10.52711/0974-360X.2022.00712
16. Ansori ANM, Kharisma VD, Fadholly A, Tacharina MR, Antonius Y, Parikesit AP. Severe Acute Respiratory Syndrome Coronavirus-2 Emergence and Its Treatment with Alternative Medicines: A Review. Res J Pharm Technol. 2021; 14(10): 5551-7. DOI: 10.52711/0974-360X.2021.00967