Author(s): Yuniati Valentina, Nida Suraya, Leni Lismayanti

Email(s): valentinayuni2019@gmail.com

DOI: 10.52711/0974-360X.2024.00050   

Address: Yuniati Valentina1*, Nida Suraya2, Leni Lismayanti2
1Clinical Pathology Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
2Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
Coronavirus Disease 2019 (COVID-19) has a clinical spectrum that varies from asymptomatic to death. Cytokine storms cause neutrophilia, lymphopenia, and thrombocytopenia at various levels of COVID-19 severity. These three parameters can be studied as markers of inflammation in the form of ratios. This study aims to discover the correlation between NLR & PLR inflammatory markers in determining the severity of COVID-19.An analytical cross-sectional study was carried out on secondary data from 274 subjects collected from the subject's hematological parameters from first day of admission to Hasan Sadikin Hospital from May-December 2020. The statistical analysis with Spearman test using the SPSS 17.0 program. There are 274 subjectswith non-severe and severe COVID-19 were NLR (3,44 vs 7,17), PLR (182,4 vs 254,4). The r coefficient of NLR and PLR reached 0.308 and 0.198, p-value of < 0.001.In the next phase, days 7-14, lymphocytes decrease significantly. This study found a weak correlation because neutrophilia occurred on the third-seventh day of treatment, while the assessment was performed at first day of admission with clinical symptoms on day 1-3. PLR and NLR have a weak positive correlation with the severity of COVID-19. Therefore, it cannot be utilized independently in determining the severity of COVID-19.


Cite this article:
Yuniati Valentina, Nida Suraya, Leni Lismayanti. Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital. Research Journal of Pharmacy and Technology. 2024; 17(1):323-6. doi: 10.52711/0974-360X.2024.00050

Cite(Electronic):
Yuniati Valentina, Nida Suraya, Leni Lismayanti. Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital. Research Journal of Pharmacy and Technology. 2024; 17(1):323-6. doi: 10.52711/0974-360X.2024.00050   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-50


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