Author(s): Viol Dhea Kharisma, A. N. M. Ansori, Ahmad Affan Ali Murtadlo, Muhammad Hermawan Widyananda, Emdad Ullah, Sin War Naw, Vikash Jakhmola, Kiran Dobhal, Tarun Parashar, Maksim Rebezov, Rahadian Zainul

Email(s): rahadianzmsiphd@fmipa.unp.ac.id

DOI: 10.52711/0974-360X.2024.00045   

Address: Viol Dhea Kharisma1,2, A. N. M. Ansori3, Ahmad Affan Ali Murtadlo2, Muhammad Hermawan Widyananda4, Md. Emdad Ullah5, Sin War Naw6, Vikash Jakhmola7, Kiran Dobhal7, Tarun Parashar7, Maksim Rebezov8,9,10, Rahadian Zainul11,12*
1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
2Computational Virology Research Unit, Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia.
3Professor Nidom Foundation, Surabaya, Indonesia.
4Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia.
5Department of Chemistry,Mississippi State University, Mississippi, United States.
6Department of Chemistry, Myitkyina University, Myitkyina, Myanmar.
7Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand, Dehradun, India.
8Department of Scientific Research, Russian State Agrarian University – Moscow Timiryazev Agricult

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
Infection with a DNA virus called monkeypox virus (MPXV) in humans has been identified in the Congo since 1970. Antiviral drugs are not effective for preventing MPXV infection. MPXV infection cases in Indonesia are very low but MPXV has the potential to become a global pandemic so it is very important to do prevention such as vaccine development. This study aims to construct a B cell epitope-based peptide vaccine candidate in Indonesian MPXV through an in silico approach.The development of the MPXV vaccine can be performed through a computational approach for preliminary studies. In silico-based construction of vaccines using B cell epitopes, antigenicity, allergenicity, docking, and molecular dynamics analysis have been used by researchers and scientists in solving viral infection cases. We recommend Pep A and Pep D as vaccine candidates because they allow recognition by B cells, antigenic peptides, non-allergenic and non-toxin. Peptide vaccine candidate can trigger B-cell activation to produce IgM isotype-specific antibodies through BCR interaction. In summary, the results of this study can be used for an initial study of MPXV vaccine development in Indonesia.


Cite this article:
Viol Dhea Kharisma, A. N. M. Ansori, Ahmad Affan Ali Murtadlo, Muhammad Hermawan Widyananda, Emdad Ullah, Sin War Naw, Vikash Jakhmola, Kiran Dobhal, Tarun Parashar, Maksim Rebezov, Rahadian Zainul. Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology. Research Journal of Pharmacy and Technology. 2024; 17(1):291-6. doi: 10.52711/0974-360X.2024.00045

Cite(Electronic):
Viol Dhea Kharisma, A. N. M. Ansori, Ahmad Affan Ali Murtadlo, Muhammad Hermawan Widyananda, Emdad Ullah, Sin War Naw, Vikash Jakhmola, Kiran Dobhal, Tarun Parashar, Maksim Rebezov, Rahadian Zainul. Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology. Research Journal of Pharmacy and Technology. 2024; 17(1):291-6. doi: 10.52711/0974-360X.2024.00045   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-45


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