Author(s): Himanshi, Pushpraj S Gupta


DOI: 10.52711/0974-360X.2024.00031   

Address: Himanshi, Pushpraj S Gupta*
Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences (Formerly Allahabad Agriculture Institute), Indalpur Road, Naini, Prayagraj - 211007, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024

Inflammation is the physiological defence system of the body to initiate the healing mechanism for tissue and eliminate injurious stimuli. In the present study, the anti-inflammatory activity of Codium elongatum was evaluated. Water extract (250 mg/kg, b.w.) and isolated polysaccharide (500 mg/kg, b.w.) are investigated in the carrageenan-induced rat paw edema model using phenylbutazone as a standard drug. Both water extract and isolated polysaccharide showed significant anti-inflammatory activity by blocking the cyclooxygenase 2 pathway. This is the first report to demonstrate the in-vivo anti-inflammatory activity of Codium elongatum.

Cite this article:
Himanshi, Pushpraj S Gupta. Anti-inflammatory activity of Codium elongatum on Carrageenan-induced paw edema in Wistar male rats. Research Journal of Pharmacy and Technology. 2024; 17(1):197-0. doi: 10.52711/0974-360X.2024.00031

Himanshi, Pushpraj S Gupta. Anti-inflammatory activity of Codium elongatum on Carrageenan-induced paw edema in Wistar male rats. Research Journal of Pharmacy and Technology. 2024; 17(1):197-0. doi: 10.52711/0974-360X.2024.00031   Available on:

1.    Amdekar S, Roy P, Singh V, Kumar A, Singh R, Sharma P. Anti-inflammatory activity of lactobacillus on carrageenan-induced paw edema in male wistar rats. International Journal of Inflammation. 2012; 1-6. doi:10.1155/2012/752015
2.    Sosa S, Balick MJ, Arvigo R, Esposito RG, Pizza C, Altinier G, Tubaro A. Screening of the topical anti-inflammatory activity of some Central American plants. Journal of Ethnopharmacology. 2002; 81(2): 211-5.
3.    Devi GK, Manivannan K, Thirumaran G, Rajathi FA, Anantharaman P. In vitro antioxidant activities of selected seaweeds from Southeast coast of India. Asian Pacific journal of tropical medicine. 2011; 4(3): 205-11.
4.    Dhargalkar VK, Pereira N. Seaweed: promising plant of the millennium. Science and Culture. 2005; 71: 60-66.
5.    Rupapara KV, Vyasi KG, Joshi NH. Nutritive properties of the Chorophyceae seaweeds available at Gulf of Kutch, Gujarat, India. International Journal of Pure & Applied Bioscience. 2017; 5: 174-9.
6.    Qari RA. Seasonal changes in biochemical composition of seaweeds from Karachi coast Pakistan. Pakistan Journal of Scientific and Industrial Research. 1988; 31(2): 94-96.
7.    Kloareg B, Quatrano RS. Structure of the cell walls of marine algae and ecophysiological functions of the matrix polysaccharides. Oceanography and Marine Biology: An Annual Review.. 1988; 26: 259-315.
8.    Pomin VH, Mourão PA. Structure, biology, evolution, and medical importance of sulfatedfucans and galactans. Glycobiology. 2008; 18(12): 1016-27.
9.    Medeiros VP, Queiroz KC, Cardoso ML, Monteiro GR, Oliveira FW, Chavante SF, Guimaraes LA, Rocha HA, Leite EL. Sulfatedgalactofucan from Lobophoravariegata: anticoagulant and anti-inflammatory properties. Biochemistry (Moscow). 2008; 73(9): 1018-24. DOI: 10.1134/S0006297908090095
10.    Siqueira RC, da Silva MS, de Alencar DB, Pires AD, de Alencar NM, Pereira MG, Cavada BS, Sampaio AH, Farias WR, Assreuy AM. In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophoravariegata. Pharmaceutical Biology. 2011; 49(2): 167-74.
11.    Wang L, Wang X, Wu H, Liu R. Overview on biological activities and molecular characteristics of sulfated polysaccharides from marine green algae in recent years. Marine Drugs. 2014; 12(9): 4984-5020.
12.    Mattison N, Gene Trimble A, Lasagna L. New drug development in the United States, 1963 through 1984. Clinical Pharmacology and Therapeutics. 1988; 43(3): 290-301.
13.    Ratheesh M, Helen A. Anti-inflammatory activity of Rutagraveolens Linn on carrageenan induced paw edema in wistar male rats. African journal of Biotechnology. 2007; 6(10).
14.    Okunade AL. Ageratum conyzoides L.(asteraceae). Fitoterapia. 2002; 73(1): 1-6.
15.    Manilal A, Sujith S, Selvin J, Kiran GS, Shakir C. In vivo antiviral activity of polysaccharide from the Indian green alga, Acrosiphoniaorientalis (J. Agardh): potential implication in shrimp disease management. World Journal of Fish and Marine Sciences. 2009; 1(4): 278-82.
16.    El-Rafie HM, El-Rafie M, Zahran MK. Green synthesis of silver nanoparticles using polysaccharides extracted from marine macro algae. Carbohydrate Polymers. 2013; 96(2): 403-10.
17.    Barros FC, da Silva DC, Sombra VG, Maciel JS, Feitosa JP, Freitas AL, de Paula RC. Structural characterization of polysaccharide obtained from red seaweed Gracilariacaudata (J Agardh). Carbohydrate Polymers. 2013; 92(1): 598-603.
18.    Hernández-Garibay E, Zertuche-González JA, Pacheco-Ruíz I. Isolation and chemical characterization of algal polysaccharides from the green seaweed Ulvaclathrata (Roth) C. Agardh. Journal of Applied Phycology. 2011; 23(3): 537-42.
19.    Buadonpri W, Wichitnithad W, Rojsitthisak P, Towiwat P. Synthetic curcumin inhibits carrageenan-induced paw edema in rats. J Health Res. 2009; 23(1): 11-6.
20.    Goncalves D, Calou IB, Siqueira RP, Lopes AA, Leal LK, Brito GA, Tomé AR, Viana GS. In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents. Brazilian Journal of Medical and Biological Research. 2011; 44: 173-81. .
21.    Sinha S, Murugesan T, Maiti K, Gayen JR, Pal M, Saha BP. Evaluation of anti-inflammatory potential of BergeniaciliataSternb. rhizome extract in rats. Journal of Pharmacy and Pharmacology. 2001; 53(2): 193-6.
22.    Dore CM, Alves MG, Will LS, Costa TG, Sabry DA, de Souza Rêgo LA, Accardo CM, Rocha HA, Filgueira LG, Leite EL. A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects. Carbohydrate Polymers. 2013; 91(1): 467-75.
23.    Chouhan YS, Kataria HC, Gosawmi CS. Anti-inflammatory activity of methanolic extract of Brassica juncea seed on carrageenan induced paw edema in rats. International Journal of Pharmaceutical Sciences and Research. 2014; 5(9): 3849.
24.    Goli V, Bhaskar KV, Macharla SP, Bhaskar J, Devi PS, Ramchander T. Effects of anti-Inflammatory activity of Mimosa pudica. Asian Journal of Pharmaceutical Research. 2011; 1(3): 69-71.
25.    Manvar MN, Desai TR. In-vitro anti-inflammatory and anti-arthritic activities of fruits of Vernonia anthelmintica Willd.(Asteraceae). Asian Journal of Pharmaceutical Research. 2014; 4(4): 186-8.
26.    Anbarasi A, Vidhya R. Evaluation of in vitro anti-inflammatory activity of Tephrosia purpurea (Seed). Asian Journal of Pharmaceutical Research. 2015; 5(2): 83-9.
27.    Shakkeel MK, Kumar A, Babu D, Swamy VB. Pharmacological evaluation of Trichilia connaroides bark for analgesic and anti-inflammatory activity in experimental animal models. Asian Journal of Pharmaceutical Research. 2015; 5(3): 138-44.
28.    Jaseela KP, Kumar A, Babu D, Swamy VB. Studies on Anti-depressant and Anti-inflammatory Activities of Curcuma aromatica Rhizome in Experimental Animal Models. Asian Journal of Pharmaceutical Research. 2016; 6(2): 79-86.
29.    Narapusetty N, Sivaiah O, Balanasaraiah B, Haranadhbabu M, Prasad B, Crown BH, Rao CM. Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model. Asian Journal of Pharmaceutical Research. 2017; 7(2): 88-93.
30.    Karthik KN, Kumar KR. Evaluation of Analgesic, Anti-Inflammatory of stem bark ethanolic Extract of Michelia champaca Linn. Asian Journal of Pharmaceutical Research. 2017; 7(2): 94-97.
31.    Gorla SN, Savithri M, Koteswara Rao GSN, Niharika Y, Devi Sree Sathya P, Harika V. Evaluation of anti-inflammatory activity of Hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation. Asian Journal of Pharmaceutical Research. 2018; 8(1): 33-35.         
32.    Shinde PP, Khule SD, Sonawane S, Shelke S. Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats. Asian Journal of Pharmaceutical Research. 2021; 11(3).
33.    Kumari A, Lalitha KG, Venkatachalam T, Kalaiselvi P, Sethuraman MG. Anti-inflammatory and Antinociceptive activity of Pavonia zeylanica Linn. Asian Journal of Pharmaceutical Research Sci. 2011; 1(4): 113-116.
34.    Godard M, Décordé K, Ventura E, Soteras G, Baccou JC, Cristol JP, Rouanet JM. Polysaccharides from the green alga Ulvarigida improve the antioxidant status and prevent fatty streak lesions in the high cholesterol fed hamster, an animal model of nutritionally-induced atherosclerosis. Food Chemistry. 2009; 115(1): 176-80.
35.    Pires CL, Rodrigues SD, Bristot D, Gaeta HH, de Oliveira Toyama D, Farias WR, Toyama MH. Evaluation of macroalgaesulfated polysaccharides on the Leishmania (L.) amazonensispromastigote. Marine Drugs. 2013; 11(3): 934-43.
36.    Heller A, Koch T, Schmeck J, van Ackern K. Lipid mediators in inflammatory disorders. Drugs. 1998; 55(4): 487-96.
37.    Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV. Protein kinase Cα (PKCα) acts upstream of PKCθ to activate IκB kinase and NF-κB in T lymphocytes. Molecular and Cellular Biology. 2003; 23(19): 7068-81.
38.    Giuliano F, Warner TD. Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems. Journal of Pharmacology and Experimental Therapeutics. 2002; 303(3): 1001-6.
39.    Brooks PM, Day RO. Nonsteroidalantiinflammatory drugs—differences and similarities. New England Journal of Medicine. 1991;324(24):1716-25. DOI: 10.1056/NEJM199106133242407.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available