Author(s): Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Arisanty

Email(s): santisinala@poltekkes-mks.ac.id

DOI: 10.52711/0974-360X.2024.00030   

Address: Santi Sinala*, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Arisanty
Department of Pharmacy Poltekkes Ministry of Health Makassar (Poltekkes Kemenkes Makassar).
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
One of the endemic plants of the island of Sulawesi, Indonesia is the Dengen plant (Dillenia serrata). One part of this plant that is claimed by the public as a treatment for vomiting blood is the bark because the stem bark contains polyphenolic compounds which are efficacious as antioxidants and sunscreens. Based on the results of the study, Dengen stem bark extract (EKBD) has been standardized and in accordance the requirements so that the extract can be formulated in pharmaceutical dosage forms, one of which is a cosmetic preparation in the form of an emulgel. This study aims to see the effect of the addition of EKBD on the physical quality of emulgel preparations and to obtain a stable emulgel product containing standardized EKBD with an accelerated storage process using variations of the gelling agent, namely carbopol 940 and CMC sodium. There are two base variations, namely the Carbopol base with a concentration of 0.25%, 0.5%, 1% with the addition of 1:1 TEA; and CMC sodium base with concentrations of 1%, 2% and 3%. Furthermore, the base and extract are combined until homogeneous. Tests include organoleptic test, pH test, viscosity test, spread ability test, adhesion test and emulsion type test. In organoleptic testing, F1 of both bases showed inhomogeneity and watery texture. In the pH test, both bases F3 did not meet the skin pH requirements. In the viscosity test, F1 on both bases was significantly different before and after storage (p<0.05). In the spread ability test, statistically, all formulas F1, F2 and F3 on both bases showed a value of p>0.05, which means there was no significant difference in the spreadability values before storage and after accelerated storage. In the adhesion test, F3 on the Carbopol base showed a significant difference (p<0.05). In the emulsion type test, both basic formulas had a oil-in-water (O/W) emulsion type. Based on the results of data analysis, the addition of EKBD affected the pH and viscosity of the EKBD emulgel and the formula that met the requirements was formula F2 based on CMC sodium, is a concentration of 2%.


Cite this article:
Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Arisanty. Development of Emulgel product from Standardized Dengen Steam Bark Extract (Dillenia serrata). Research Journal of Pharmacy and Technology. 2024; 17(1):188-6. doi: 10.52711/0974-360X.2024.00030

Cite(Electronic):
Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Arisanty. Development of Emulgel product from Standardized Dengen Steam Bark Extract (Dillenia serrata). Research Journal of Pharmacy and Technology. 2024; 17(1):188-6. doi: 10.52711/0974-360X.2024.00030   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-30


REFERENCES:
1.    Pitopang R, and Ihan M. Biodiversitas Tumbuhan di Cagar Alam Morowali Sulawesi Tengah. Online Jural of Natural Science. 2014; 3(3): 287-286.
2.    Ilma, N. Studi Pembuatan Dodol Buah Dengen  (Dillenia Serrata Thunb). Skripsi. Makassar: Teknologi Pangan, Fakultas Pertanian. Universitas Hasanuddin. 2012
3.    Hasniarti. Studi Pembuatan Permen Buah Dengen. Skripsi. Makassar: Program Studi Ilmu Dan Teknologi Pangan, Jurusan Teknologi Pertanian Fakultas Pertanian. Universitas Hasanuddin Makassar. 2012
4.    Mustafa, S.W.  Pengolahan Buah Denegn sebagai Bahan Dasar pembuatan Sirup Buah Dengen. STIE Muhammadiyah Palopo. Prosiding Seminar Nasional . 2017; 3(1).
5.    Windardi, F. I., Rahayu, M., Uji, T., Rustiami, H. (2006). Pemanfaatan tumbuhan sebagai bahan obatoleh masyarakat lokal suku Muna di kecamatan Wakarumba, kabupaten Muna, Sulawesi Utara. Biodiversitas, 7, 339-339
6.    Sinala, S., Ibrahim I, Salasa, AM. Profile of Total Polyphenol Of The Ethanol Extract From Dengen ( Dillenia Serrata ) Leaf And Stem Bark Which Comes From Malangke City Luwu District. Proceeding International Conference. ICUH. 2019. Makassar
7.    Sinala S, Ibrahim I, Salasa AM. The Ability Free Radical Binding of Dengen’s Stem Bark Extract (Dillenia serrata) From Luwu District Indonesia. Pharmacognosy Journal. 2020; 12(6): 1340-1345.
8.    Kunle, O F., Egharevba, H O., Ahmadu, P O.  Standardization of herbal medicines - A review, International Journal of Biodiversity and Conservation. 2012; 4(3): 101-112
9.    Archana A. Bele, AK. Review Article: Standardization Of Herbal Drugs: An Overview Archana A.  Int Res J Pharm. 2011; 2(12): 56–60.
10.    Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi, Sesilia Rante Pakadang, Jumain, Arisanty. Standardization of Dengen Bark Extract (Dillenia serrata) for Emulgel Product Development. Research Journal of Pharmacy and Technology. 2022; 15(11): 5196-2. doi: 10.52711/0974-360X.2022.00875
11.    Satya Lakshmi S, Divya R, Srinivasa Rao Y, Kamala Kumari PV, Deepthi K. Emulgel-Novel Trend in Topical Drug Delivery System - Review Article. Research Journal of Pharmacy and Technology. 2021; 14(5): 2903-6. doi: 10.52711/0974-360X.2021.00509
12.    Rohini Reddy, Shanthi Priya, Ganesh Akula, Suddagoni Santhosh, Albert Jaswanth. Formulation and Evaluation of Naproxen Emulgel for Topical Delivery. Research Journal of Pharmacy and Technology. 2021; 14(4): 1961-5. doi: 10.52711/0974-360X.2021.00347
13.    Rishu Yadav, Narendra Kumar Pandey, Rajiv Kukkar, Deepika Dutta, Preeti Avasthi, Monika Rana, Swati Modgil. Emulgel A Reliable System for Topical Delivery of Lipophilic Drugs in Present Scenario: Review. Research Journal of Pharmacy and Technology. 2022; 15(6): 2845-8. doi: 10.52711/0974-360X.2022.00475
14.    Shikha Baghel Chauhan. Formulation and Evaluation of Emulgel for the treatment of Acne. Research J. Pharm. and Tech. 2020; 13(8): 3598-3602. doi: 10.5958/0974-360X.2020.00636.8
15.    Jiyauddin Khan, Siti Norfarhani, Ram K Sahu, Sakina Ruhi, Mohammed Kaleemullah, Samer Al-Dhalli, Mohamed Rasny, Sri Budiasih, Shariq Baber, Chean Hui Ng, Nik Nur Shamiha, Gulam Muhammad Khan, Gamal O. E., Santosh Fattepur, Kiran Nilugal, Ibrahim Abdullah, Fadli Asmani, Eddy Yusuf. Development and Evaluation of topical Emulgel of Aspirin using different Polymeric Bases. Research J. Pharm. and Tech. 2020; 13(12): 6300-6304. doi: 10.5958/0974-360X.2020.01096.3
16.    Swarupananda Mukherjee, Subhasis Maity, Bijaya Ghosh, Arijit Mondal. Accelerated Stability study of Preformulated glyburide loaded Lyophilized lipid Nanoparticles. Research J. Pharm. and Tech. 2020; 13(7): 3323-3325. doi: 10.5958/0974-360X.2020.00589.2
17.    Voigt R., 1994. Buku Pelajaran Teknologi Farmasi, Edisi V. Penerbit Gadjah MadaUniversity Press:Yogyakarta.
18.    Aditya Sharma, Jashanpreet Kaur, Anju Goyal, Carbopol 940 Vs Carbol 904: A better Polymer for Hydrogel Formulation. Research J. Pharm. and Tech. 2010; 3(3): 672-675. doi: 10.5958/0974-360X.2021.00275.4
19.    Ni NyomanYuliani, Jefrin Sambara, Sandeep Poddar, Urmisha Das. Formulation and characterization of Sauropus androgynous (L) Merr leaf extract Gel in Combination with CMC-Na and Carbopol 940 Using DPPH Method. Research Journal of Pharmacy and Technology. 2022; 15(11):5211-6.
20.    Martin, A., Swarbrick, J. and Cammarata, A., 2008, Farmasi Fisik, Edisi Ketiga, Penerbit UI Press, Jakarta.
21.    Mohamed A. El-Nabarawi, Ahmed H.El-Shafai, Dina M. MahmoudAbdelfattah. Formulation andevaluation of gatifloxacin topicalsemisolid dosage forms. WorldJournal of Pharmaceutical Research. 2015; 4(5): 2753-2772
22.    Gibson, M., 2001, Pharmaceutical Preformulation and Formulation, 546-550, CRC Press, United States of America.
23.    Nawar Haddad, Jameela Hasian. Effect of combination of some Polymers with Carbopol 940 on Pregabalin Release Rate from Emulgels. Research Journal of Pharmacy and Technology. 2022; 15(5): 2003-9.
24.    Erwati, Tristiana, Rosita, N. , Hendroprasetyo, W. and Dien R. J. Pengaruh Jenis Basis Gel Dan Penambahan NaCl (0.5% -b/b) Terhadap Intensitas Echo Gelombang Ultrasonik Sediaan Gel Untuk Pemeriksaan USG (Acoustic Coupling Agent), Airlangga Journal of Pharmacy. 2005; 5(2).
25.    Imerson, A. (Ed)., 1992, Thickening and Gelling Agent form Food, Blackie Akademic and Proffesional, Glasgow
26.    Younis DKK. Stability testing in pharmacy: a review. International Journal of Institutional Pharmacy and Life Sciences. 2015; 5(1): 108-116.
27.    Carstensen, dkk. 2000. Drug stability principles and practice. Marcel Dekker.Inc, New York, USA.
28.    Simon, Patrisia. Formulasi Dan Uji Penetrasi Mikroemulsi Natrium Diklofenak Dengan Metode Sel Difusi Franz Dan Metode Tape Stripping, Skripsi, Prodi Farmasi FMIPA Universitas Indonesia, Depok. 2012
29.    Permatasari, V.S., 2014, Pengaruh Konsentrasi Carbopol 940 sebagai Gelling Agent Terhadap Sifat Fisik dan Stabilitas Gel Hand Sanitizer Minyak Daun Mint (Oleum Mentha piperita), Skripsi, Fakultas Farmasi Universitas Sanata Dharma, Yogyakarta SNI(1996).SNI16-4399-1996. Sediaan Tabir Surya. Dewan Standarisasi Nasional. Jakarta.
30.    Garg, A., D. Aggarwal, S. Garg, and A. K. Sigla. Spreading of Semisolid Formulation: An Update. Pharmaceutical Tecnology. 2002;  84-102.
31.    Kurniawan, M., Sugihartini, N dan Yuwono, T. Permeabilitas dan KarakteristikFisik Emulgel MinyakAtsiriBunga Cengkeh dengan Penambahan Enhancer. Medical Sains. 2008; 3(1).

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available