Author(s): Rajesh Sinha, Rahul Singh, Manisha Chandrakar, Arun KS Parihar

Email(s): arunpharma1986@gmail.com

DOI: 10.52711/0974-360X.2024.00028   

Address: Rajesh Sinha2, Rahul Singh3, Manisha Chandrakar4, Arun KS Parihar1,2*
1Drug Testing Laboratory Evam Anusandhan Kendra, Raipur (C.G) 492010.
2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G), 492010.
3M.J. College, Junwani Road, Kohka, Bhilai (C.G), 490023.
4M.J. College, Junwani Road, Kohka, Bhilai (C.G), 490023.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
Nanoemulsions are most promising delivery system for the natural bioactives compounds which posses poor bioavailability due to low solubility. Nanoemulsions as dosage delivery system and formulations have been found to be suitable for loading high amount of drugs to improve its therapeutic effect. These are widely used in cosmetics, diagnostic, drug therapies and bioactives because of the nanosized formulation. In the present work, nanoemulsion formulations of curcumin were prepared by using the tamarind gum as emulsifier using hot homogenization method. The six batches (F1, F2, F3, F4, F5 and F6) of nanoformulations were prepared and optimized on the basis of particle size and zeta potential. The optimized nanoemulsion (F3) which one reported to have particle size of 173.5 ±nm with zeta potential of -33.2±mV. The drug content was found to be 70% and the particles were found to be spherical, smooth and non-aggregated. The formulation were found to be stable in tested conditions. Thus, tamarind gum as a natural polymer can be used as stabilising, gelling, thickening, binding and muco- adhesive agents for formulation of novel drug delivery system of various drugs.


Cite this article:
Rajesh Sinha, Rahul Singh, Manisha Chandrakar, Arun KS Parihar. Designing of Curcumin nanoemulsion by using Tamarind gum as Natural Emulsifying agent. Research Journal of Pharmacy and Technology. 2024; 17(1):172-8. doi: 10.52711/0974-360X.2024.00028

Cite(Electronic):
Rajesh Sinha, Rahul Singh, Manisha Chandrakar, Arun KS Parihar. Designing of Curcumin nanoemulsion by using Tamarind gum as Natural Emulsifying agent. Research Journal of Pharmacy and Technology. 2024; 17(1):172-8. doi: 10.52711/0974-360X.2024.00028   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-28


REFERENCES:
1.    Avachat AM, Dash RR, Shrotriya SN. Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Ind J Pharm Edu Res. 2011; 45(1): 86-99.
2.    Prasanna JL, Deepthi B, Rao NR. Design and optimization of matrix tablets of diclofenac sodium using a natural gum. Research Journal of Pharmacy and Technology. 2012; 5(6): 846-52.
3.    Nagar PK, Nayyar P, Sharma PK. Extraction and evaluation of Isapghula seed Polymer AS Pharmaceutical Excipient. Journal of Drug Delivery and Therapeutics. 2014; 4(3):122-4.
4.    Manchanda R, Shrivastava B, Arora SC, Manchanda R. Formulation, evaluation and optimization of tamarind seed polysaccharide based glipizide sustained release matrix tablets by 32 full factorial design. International Journal of PharmTech Research. 2015; 7(2): 380-91.
5.    Patel B, Patel P, Bhosale A, Hardikar S, Mutha S, Chaulang G. Evaluation of tamarind seed polysaccharide (TSP) as a mucoadhesive and sustained release component of nifedipine buccoadhesive tablet & comparison with HPMC and Na CMC. Int J Pharm Tech Res. 2009; 1(3): 404-10.
6.    Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, Rocha-Filho PA. Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments. Journal of Nanobiotechnology. 2011; 9(1): 1-9.
7.    Karki D, Kulkarni GS, Swamy S, Sheeba FR. Formulation and evaluation of mucoadhesive buccal tablets of curcumin and its bioavailability study. Research Journal of Pharmacy and Technology. 2017; 10(12): 4121-8.
8.    Samanta A, Roy A, Majumdar M. Study of various formulations for enhancement of systemic bioavailability of curcumin. Research Journal of Pharmacy and Technology. 2018; 11(2): 661-6.
9.    de Campos VE, Ricci-Junior E, Mansur CR. Nanoemulsions as delivery systems for lipophilic drugs. Journal of Nanoscience and nanoTechnology. 2012; 12(3): 2881-90.
10.    Prasetyo BE, Maruhawa SM, Laila L. Formulation and physical evaluation of castor oil based nanoemulsion for diclofenac sodium delivery system. Research Journal of Pharmacy and Technology. 2018; 11(9): 3861-5.
11.    Burapapadh K, Kumpugdee-Vollrath M, Chantasart D, Sriamornsak P. Fabrication of pectin-based nanoemulsions loaded with itraconazole for pharmaceutical application. Carbohydrate Polymers. 2010 ; 82(2): 384-93.
12.    Eqbal A, Ansari VA, Hafeez A, Ahsan F, Imran M, Tanweer S. Recent applications of nanoemulsion based drug delivery system: A review. Research Journal of Pharmacy and Technology. 2021; 14(5): 2852-8.
13.    Kulkarni D, Dwivedi AK, Singh S. Performance evaluation of tamarind seed polyose as a binder and in sustained release formulations of low drug loading. Indian Journal of Pharmaceutical Sciences. 1998; 60(1): 50-3.
14.    Alam S, Sharma P. Stability study of clobetasol propionate loaded tea tree oil nanoemulsion as per ICH guidelines. Research Journal of Pharmacy and Technology. 2016; 9(11): 1999-2004.
15.    Gupta V, Puri R, Gupta S, Jain S, Rao GK. Tamarind Kernel Gum: An Upcoming Natural Polysaccharide. Systematic Reviews in Pharmacy. 2010 ; 1(1).

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