Author(s): Supriya Dubey, Abha Shukla

Email(s): ,

DOI: 10.52711/0974-360X.2024.00026   

Address: Supriya Dubey, Abha Shukla*
Department of Chemistry, Kanya Gurukul Campus, Gurukula Kangri (Deemed to be University), Haridwar - 249407, Uttarakhand, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024

Background: Plants are the prime source of phytoconstituents that can act as potent agents for the prevention and treatment of various diseases. Heterospathe elata is a plant belonging to the Arecaceae family having numerous medicinal properties. The present study aimed to investigate the antidiabetic and anti-inflammatory activities of green solvent extracts of Heterospathe elata fruit. Method: The extraction was carried out with green solvents like isopropyl alcohol, hydro alcohol, and water with increasing order of polarity. In-vitro antidiabetic activity was evaluated by alpha-amylase and alpha-glucosidase inhibition assays. Anti-inflammatory activity was evaluated by the Bovin denaturation method and HRBC membrane stabilization. Result: Our results revealed that out of three green extracts hydro alcohol extract of Heterospathe elata fruit had the highest antidiabetic and anti-inflammatory activity. Conclusion: The results suggest that the fruit of Heterospathe elata is a potential source of antidiabetic and anti-inflammatory properties.

Cite this article:
Supriya Dubey, Abha Shukla. Antidiabetic and Anti-inflammatory activity of Green Solvent Extracts of Heterospathe elata fruits. Research Journal of Pharmacy and Technology. 2024; 17(1):163-8. doi: 10.52711/0974-360X.2024.00026

Supriya Dubey, Abha Shukla. Antidiabetic and Anti-inflammatory activity of Green Solvent Extracts of Heterospathe elata fruits. Research Journal of Pharmacy and Technology. 2024; 17(1):163-8. doi: 10.52711/0974-360X.2024.00026   Available on:

1.    Jignasu PM. Parmar PH. Vadia SH. Patel MK. Tripathi CB et al In vitro antioxidant and in-vivo anti-inflammatory activities of aerial parts of Cassia species. Arab J Chem. 2017;10:1654–1662.
2.    Ahmed AE. Harraz FM. Ghareib SA. Gabr SA. Nagy AA. Abdel-Sattar E et al Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats. Int J Diabetes Mellit. 2015; 3: 37-44. doi.10.1016/j.ijdm.2011.01.004
3.    James P. Davis SP. Ravisankar V. Nazeem PA. Mathew D et al Novel Antidiabetic Molecules from the Medicinal Plants of Western Ghats of India, Identified Through Wide-Spectrum in Silico Analyses. J herbs Spices med plants. 2017; 23: 249-262. doi.10.1080/10496475.2017.1315675.
4.    Nikhat F. Satynarayanaa D. Joshia AB et al Phytochemical and Pharmacological Investigation of Roots of Syzygium Cuminii (L) Skeel. Asian J. Research Chem. 2008; 1(1): 22-25.
5.    Ohikhena FU. Wintola OA. Afolayan AJ et al Investigating the antidiabetic potential of Phragmanthera capitata, a mistletoe harvested from rubber tree. J herbs Spices med plants. 2018; 24: 1-9.
6.    Tarafdar RG. Nath S. Talukdar AD.Choudhury MD et al Antidiabetic plants used among the ethnic communities of Unakoti district of Tripura, India. Journal of Ethnopharmacology. 2015; 160: 219-226.
7.    Reasner CA et al Reducing cardiovascular complications of type 2 diabetes by targeting multiple risk factors. J Cardiovasc Pharmacol. 2008; 52: 136–44.
8.    Priya ES. Selvan PS. Ajay B et al Tannin rich fraction from Terminalia chebula fruits as Anti-inflammatory agent. J herbs Spices med plants. 2018; 24: 1. doi: 10.1080/10496475.2017.1399953.
9.    Shaikh RU. Pund MM. Gacche RN et al Evaluation of anti-inflammatory activity of selected medicinal plants used in Indian traditional medication system in vitro as well as in vivo. J Traditi Complement Med. 2016; 6(4): 355-361. doi.10.1016/j.jtcme.2015.07.001
10.    Dubey S. Shukla A. Shukla RK et al Metabolomic profile by GC/MS and Antioxidant, Antidiabetic and Anti-Inflammatory  activities of green solvent extracts of Heterospathe elata leaves. Chem. Biodiversity. 2023; 20(7): e202300340.
11.    Zhuo Z. Wanpeng X. Yan H. Chao N. Zhiqin Z et al Antioxidant activity of Citrus fruits. Food Chem. 2016; 196: 885-896.
12.    Souza FGD. Araújo FFD. Farias DDP. Zanotto AW. Neri-Numa IA. Pastore GM et al Brazilian fruits of Arecaceae family: An overview of some representatives with promising food, therapeutic and industrial applications. Food Research International. 2020; 138:109690.
13.    Shukla A. Dubey S et al A review: traditionally used medicinal plants of family arecaceae with phytoconstituents and therapeutic applications. Int. J. Biol. Pharm. Allied Sci. 2022; 11(12): 5864-5877.
14.    EmilioT. Lamarque LJ. Torres-Ruiz JM. King A. Charrier G. Burlett R. Delzon S et al Embolism resistance in petioles and leaflets of palms. Annals of Botany. 2019.
15.    Islam A. Abdelhakim MA. El-Mokhtar AM. Abd EB. Dauod WB et al Chemical constituents and antimicrobial activity of the leaves of Caryota mitis Lour. (Arecaceae).J. Med. Plants Stud. 2017; 5(5): 250-255.
16.    Kazeem M. Idowu A.Tom AO et al In-vitro antioxidant and antidiabetic potentials of Dianthus basuticus Burtt Davy whole plant extracts. J Herb Med. 2015; 5: 158-164.
17.    Kim JS. Yang J. Kim MJ et al Alpha glucosidase inhibitory effect, antimicrobial activity and UPLC analysis of Rhus verniciflua under various extract conditions. J Med Plants Res. 2011; 5: 778-783.
18.    Chandra S. ChatterjeeP. Dey PS. Bhattacharya et al Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein. Asian Pac. J. Trop. Biomed. 2012; 2(1): 178-180.
19.    Subramanian S. Rajeswari S. Sriram Prasath G et al Antidiabetic, Antilipidemic and Antioxidant Nature of Tridax procumbens Studied in Alloxan-Induced Experimental Diabetes in Rats: a Biochemical Approach. Asian J. Research Chem. 2011; 4(11): 1732-1738.
20.    Capello C. Fischer U. Hungerbühler K et al What is a green solvent? A comprehensive frame work for the environmental assessment of solvents. Green Chem. 2007; 9(9): 927–933.
21.    Villanueva Bermejo D. Angelov I. Vicente G. Stateva RP. Rodriguez García-Risco M. Reglero G et al Extraction of thymol from different varieties of thyme plants using green solvents. J Sci Food Agric. 2015; 95(14): 2901–2907.
22.    Welton T et al Solvents and sustainable chemistry. Proc R Soc A Math Phys Eng Sci. 2015; 471(2183).
23.    Shukla A. Kaur A. Shukla RK. Anchal et al Comparative evaluation of antioxidant capacity, total flavonoid and phenolic content of Ehretia acuminata r. br. fruit. Res J Pharm Technol. 2019; 12(4): 1811–6.
24.    Saffiya BA. Sheila J. Sarah JM. Saraswathi K. Arumugam P et al Screening of secondary metabolites, bioactive compounds in vitro antioxidant,antibacterial, antidiabetic, anti-inflammatory activities of chia seeds (salvia hispanica l.) Res J Pharm Technol. 2021; 14(12): 6289 6294. doi: 10.52711/0974-360X.2021.01088.
25.    Shukla A. Pokhriyal P et al A desirability approach for Antidiabetic and Anti-inflammatory efficacy of Ficus subincisa bark Research J. Pharm. and Tech. 2022; 15(4).
26.    Pandurang M. Gaikwad, Vikram V. Nimbalkar, Priyanka K. Sabale, Ganesh D. B et al Evaluation of Sertraline as an antioxidant, anti-inflammatory and anticataract. Research Journal of Pharmacy and Technology. 2021; 14(12): 6413-6. doi: 10.52711/0974-360X.2021.01109.
27.    Sugumaran M. Vetrichelvan T. Darlin Quine S et al Antidiabetic potential of aqueous and alcoholic leaf extracts of Pithecellobium dulce. Asian J. Research Chem. 2009; 2(1): 83-85.
28.    Ramesh B. Umashankar RN. Babitha S et al Synthesis and Anti-inflammatory Activity of Some New 2-Amino – 4, 6, Diaryl Pyrimidines. Asian J. Research Chem. 2019; 3(1): 29-30.
29.    Aejaz A. Khurshid IM. Gulam JK et al Synthesis, characterization and anti-inflammatory activity some 1-(4-substituted)-2-(-4-(piperazine-1-yl) bis-thiazole-5-yl) 2-methyl-4-nitro-1h-imidazole-1-yl) ethanone. Asian J. Research Chem. 2017; 10(2): 158-165.
30.    Dipika V. Anna PN et al Efficient One Pot Green Synthesis of 2-Aryl/ Heteryl- Benzothiazoles as Anti-inflammatory Agents. Asian J. Research Chem. 2010; 3(4): 872-875.
31.    Nupur J. Arvind KS et al Synthesis of Some Novel 2, 5-Disubstituted 1, 3, 4-Oxadiazole Derivatives as Potential Antibacterial and Anti-inflammatory activity. Asian J. Research Chem. 2013; 6(2): 111-113.

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