Author(s): Venkata Lakshmi J, Ch. M. Kumari Chitturi, C. Appa Rao

Email(s): chandi2222002@yahoo.co.in

DOI: 10.52711/0974-360X.2024.00013   

Address: Venkata Lakshmi J1, Ch. M. Kumari Chitturi2*, C. Appa Rao3
1Department of Chemistry, Government College for Men (Autonomous), Kadapa - 516 004, Andhra Pradesh, India.
2Department of Applied Microbiology and Bio Chemistry, Sri Padmavati Mahila Visvavidyalayam, Tirupati - 517502, Andhra Pradesh, India.
3Department of Bio Chemistry, Sri Venkateswara University, Tirupati - 517 502, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
Diabetes Mellitus is characterized by abnormal Metabolism of glucose. The maintenance of glucose levels in blood without any side effects is still challenging in the medication of this disease. Various medical approaches like Allopathy, Homeopathy, Ayurveda, Unani etc are striving a lot for success in this field of medication. Present study is aimed to evaluate the Antidiabetic activity of Millets in combination with Kamadhenu Ark as solvent for the probable alpha Amylase and alpha Glucosidase inhibitory activities to reduce hyperglycemia. The Millets namely Paspalum scrobiculatum, Panicum miliaceum, Panicum sumatrense were selected for the study. The Kamadhenu Ark Extracts were prepared by Maceration method. The extracts were used for the estimation of alpha amylase and alpha-glucosidase inhibition activity. Extract of Panicum miliaceum exhibited highest a amylase and a glucosidase inhibitory potential with IC50 values of 0.239 and 1.526 mg/ml, respectively, which was comparable with acarbose (0.258 and 1.985 mg/ml). Extracts of Paspalum scrobiculatum and Panicum sumatrense have shown low activity. Present study paves a new path revealing the effective inhibition of a amylase and a glucosidase by Kamadhenu Ark extract of Panicum miliaceum (Proso Millet KPM).


Cite this article:
Venkata Lakshmi J, Ch. M. Kumari Chitturi, C. Appa Rao. In Vitro Evaluation of Alpha Amylase and Alpha Glucosidase Inhibitory Activity of Kamadhenu Ark extracts of Climate Smart Crop Millets. Research Journal of Pharmacy and Technology. 2024; 17(1):81-6. doi: 10.52711/0974-360X.2024.00013

Cite(Electronic):
Venkata Lakshmi J, Ch. M. Kumari Chitturi, C. Appa Rao. In Vitro Evaluation of Alpha Amylase and Alpha Glucosidase Inhibitory Activity of Kamadhenu Ark extracts of Climate Smart Crop Millets. Research Journal of Pharmacy and Technology. 2024; 17(1):81-6. doi: 10.52711/0974-360X.2024.00013   Available on: https://rjptonline.org/AbstractView.aspx?PID=2024-17-1-13


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