Author(s): Prajakta Khule, Vrunal More, Manojkumar Nitalikar, Mithun Maniyar

Email(s): pkkhule@cop.sveri.ac.in , vvmore@cop.sveri.ac.in , mmnitalikar@gmail.com , mgmaniyar@cop.sveri.ac.in

DOI: 10.52711/0974-360X.2023.00723   

Address: Prajakta Khule1*, Vrunal More1, Manojkumar Nitalikar2, Mithun Maniyar1
1SVERI’S College of Pharmacy, Gopalpur - Pandharpur, Maharashtra - 413304, India.
2Rajarambapu College of Pharmacy, Kasegaon, Sangli. Maharashtra - 415409, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
Topical dosage forms are successfully used as drug delivery systems to treat various fungal infections considering their ability to control drug release and to protect medicaments from a hostile environment. Thus, it was desired in this study to topical Itraconazole gel that could be used locally in the treatment of various fungal infections. Itraconazole is an imidazole derivative and used for the treatment of various local and systemic fungal infections. The oral use of Itraconazole has many side effects, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. FT-IR study confirmed the purity of drug. Carbopol 940 (1.5%), HPMC (3%) were used as gelling agents. Different penetration enhancers like Tween 80, oleic acid and propylene glycol were used in 2.5,5,10 proportions in gel formulations. Total 20 batches were prepared by using two gelling agents and three penetration enhancers. Gel formulations were characterized for drug content, pH determination, viscosity measurement, spreadability, in vitro diffusion and skin irritation. All the gel formulations showed satisfactory results for above parameters. Diffusion study is carried out to check penetrability of penetration enhancers. Carbapol gel formulation containing maximum concentration of Tween 80 i.e.10% (Batch CF4) is selected as optimized formulation, due to highest diffusion. Thus topical gel with Tween 80 is found more effective for topical Itraconazole delivery with better penetration, where skin is the target site for to treat fungal infections.


Cite this article:
Prajakta Khule, Vrunal More, Manojkumar Nitalikar, Mithun Maniyar. Effect of Penetration enhancers on Topical Antifungal gel. Research Journal of Pharmacy and Technology 2023; 16(9):4431-5. doi: 10.52711/0974-360X.2023.00723

Cite(Electronic):
Prajakta Khule, Vrunal More, Manojkumar Nitalikar, Mithun Maniyar. Effect of Penetration enhancers on Topical Antifungal gel. Research Journal of Pharmacy and Technology 2023; 16(9):4431-5. doi: 10.52711/0974-360X.2023.00723   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-9-67


REFERENCES:
1.    Surver, C. and Davis, F.A., “Bioavailability and Bioequivalence”, In Walter, K.A. (Ed.), Marcal Dekker, INC. NewYork, 119, 2002; 323-403.
2.    Jain NK. “Controlled and Novel Drug Delivery”. 1st edition, CBS Publishers and Distributors, 1997; 100.
3.    Chien YW. “Novel Drug Delivery Systems”. 2nd edition, Vol. 50, edited by James Swarbrick, Marcel Dekker, New York, 2007; 301-302.
4.    Khule PK, More VV, Gilhotra RM. Development, characterization of novel microsponge loaded gel to treat various fungal infections. IJPR. 2020; 12(3): 603-08.
5.    More VV, Nitalikar MM, Gilhotra RM. Topical Gel for Psoriasis, International Journal of Pharmaceutical and Biological Archives. 2019; 10(1): 37-42.
6.    Spreadability Testing Apparatus, [Indian Patent Application No 201921010606].
7.    Rasool BKA, Abu-Gharbieh EF, Fahmy SA, Saad HS and Khan SA. Development and evaluation of Ibuprofen transdermal gel formulations. Tropical Journal of Pharmaceutical Research. 2010; 9(4): 355-363.
8.    Khambete H. Gellified emulsion for sustain delivery of Itraconazole for topical fungal diseases. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2: 104-112.
9.    Bseiso EA. Nasr M, Sammour O, Abd El Gawad NA. Recent advances in topical formulation carriers of antifungal agents. Indian J Dermatol Venereol Leprol. 2015; 81: 457-63.
10.    Kedar B et. al. The Impact of Penetration Enhancers on Transdermal Drug Delivery System: Physical and Chemical Approach. IJPRR. 2015; 4(7) :14-24

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available