Author(s): Ariana Younes, Mazen Khaddour, Mazen Salloum, Suzan Samra, Samer Akel

Email(s): arianayounis@tishreen.edu.sy , ph.arianayounes@gmail.com

DOI: 10.52711/0974-360X.2023.00714   

Address: Ariana Younes1*, Mazen Khaddour1, Mazen Salloum2, Suzan Samra1,3, Samer Akel4
1Department of Biochemistry and Microbiology, Tishreen University, Latakia – Syria.
2AlHawash Private University, Homs, Syria.
3Al-Andalus University for Medical Sciences, Tartous, Syria.
4Assistant Professor, Department of Oncology and Hematology, Tishreen University Hospital Latakia – Syria.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutations can reduce the activity of the enzyme, which has been shown to be a significant factor in the risk of developing certain types of cancer and numerous other diseases, including cardiovascular conditions, diabetes, ischemia, venous thrombosis, hypotonia, and many others. This study aims to determine the frequency of the two most prevalent MTHFR gene polymorphisms, C677T and A1298C, in the Syrian coastal population. Real-time PCR is used to detect MTHFR gene variants in samples from seventy healthy males from Syrian Coastal Area. The frequency of the C/C, C/T, and T/T genotypes for the C677T polymorphism was 47.14 percent, 38.57 percent, and 14.29 percent, respectively. The overall carrier rate was 52.86%, and the allelic frequency was 0.336. The genotypic prevalence of A/A, A/C, and C/C for the A1298C polymorphism was 44.29%, 35.71%, and 20%, respectively, with an allelic frequency of 0.378, while the overall carrier rate was 55.71%. In conclusion, the high prevalence of the MTHFR A1298C polymorphism is a significant finding that must be investigated in terms of clinical implications and reveals an additional genetic trait unique to the Syrian coast population.


Cite this article:
Ariana Younes, Mazen Khaddour, Mazen Salloum, Suzan Samra, Samer Akel, Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area, Research Journal of Pharmacy and Technology 2023; 16(9):4365-9. doi: 10.52711/0974-360X.2023.00714

Cite(Electronic):
Ariana Younes, Mazen Khaddour, Mazen Salloum, Suzan Samra, Samer Akel, Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area, Research Journal of Pharmacy and Technology 2023; 16(9):4365-9. doi: 10.52711/0974-360X.2023.00714   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-9-58


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