Author(s): Asha Mary John, Anjana Baby, Asmin Juberia Rahim, Besteena Baby, Elsa Babu


DOI: 10.52711/0974-360X.2023.00696   

Address: Asha Mary John1*, Anjana Baby2, Asmin Juberia Rahim2, Besteena Baby2, Elsa Babu2
1MGM Silver Jubilee College of Polytechnic and Pharmaceutical Sciences, Department of Pharmacology, Pampakuda, Ernakulam, Kerala, India.
2Chemists College of Pharmaceutical Sciences and Research, Department of Pharmacology, Ernakulam, Kerala, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023

The purpose of this study is to assess the hypolipidemic potential of formulated suspensions of atorvastatin, alcoholic extract of Murraya koenigii and their combination on hyperlipidemic Wistar rats. Hyperlipidemia was induced in all groups except negative control group, using High Fat Diet (HFD). Formulated suspensions of Murayya koenigii leaf extract, atorvastatin and its combination were administered to HFD fed rats for 28 days. Treatment related changes in body weights were recorded. Extraction of Murraya koenigii was carried out by maceration. After completion of treatments, blood samples were collected immediately and serum separated was used for the estimation of lipid profile and glucose levels. Treatment with all the formulated suspensions shows significant normalization of body weight compared with positive control group (62.5±3.14) in HFD fed animals. The effect of combined suspension was more pronounced (40.08±4.86) and shows significant reduction in body weight gain, P<0.01 than that of Murraya koenigii leaf extract (57.94 ±4.36) or atorvastatin suspensions (45.97± 4.48) alone. Combined suspension also exhibits significant reduction, P<0.001 in serum TC, TG, LDL and VLDL. It also enhanced the cardio protective lipid HDL after 28 days of treatment. A significant reduction in serum glucose levels were noted with suspension of Murraya koenigii leaf extract alone, P<0.05 compared with positive control. It is possible to draw the conclusion from the current study that combining atorvastatin and Murraya koenigii leaf extract in a suspension may have had a synergistic effect on lowering body weight and hypolipidemic activity.

Cite this article:
Asha Mary John, Anjana Baby, Asmin Juberia Rahim, Besteena Baby, Elsa Babu. Evaluation of Synergistic Hypolipidemic Activity of Murraya koenigii and Atorvastatin suspension in Hyperlipidemic rats. Research Journal of Pharmacy and Technology 2023; 16(9):4251-6. doi: 10.52711/0974-360X.2023.00696

Asha Mary John, Anjana Baby, Asmin Juberia Rahim, Besteena Baby, Elsa Babu. Evaluation of Synergistic Hypolipidemic Activity of Murraya koenigii and Atorvastatin suspension in Hyperlipidemic rats. Research Journal of Pharmacy and Technology 2023; 16(9):4251-6. doi: 10.52711/0974-360X.2023.00696   Available on:

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