Author(s): Jasmeet Kaur Chahal, Jasmine Chaudhary, Samrat Chauhan, Akash Jain, Ashwani Dhingra, Bhawna Chopra

Email(s): akash2911@gmail.com

DOI: 10.52711/0974-360X.2023.00660   

Address: Jasmeet Kaur Chahal1, Jasmine Chaudhary1, Samrat Chauhan1, Akash Jain1*, Ashwani Dhingra2, Bhawna Chopra2
1MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala - 133207, Haryana, India.
2Guru Gobind Singh College of Pharmacy, Yamunanagar - 135001, Haryana, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
Background: Arthritis, an age-related chronic inflammatory autoimmune disease primarily characterized by joint pain, swelling, stiffness, cartilage destruction, is increasing tremendously at an alarming rate and also becoming a major risk factor for other health complications. Cordia myxa, family Boraginaceae is an herbal plant used since ancient times for its various significant pharmacological activities, including anti-inflammatory effects. Scientific studies reporting anti-arthritic potential of leaves extract of this plant are still lacking. Therefore, the present work has been designed to investigate the protective effect of ethanolic extract of Cordia myxa leaves in Freund’s complete adjuvant (FCA)-induced arthritis in rats. Methods: Ethanolic extract (100mg/Kg, 200mg/Kg and 400mg/Kg) was investigated for their efficacy in the management of FCA induced arthritis in rats. Various parameters like paw volume (using plethysmograph), paw thickness (using Vernier calliper), body weight, hematological and histopathological profile were observed. The protocol was approved by Institutional Animal Ethical Committee (MMCP/IAEC/94) and was according to CPCSEA guidelines. Results: The phytochemical screening reveals the presence of flavonoids, glycosides, alkaloids, saponins and carbohydrates in the ethanolic extract of Cordia myxa leaves. Promising results with significant improvement were discovered as evident from all determined parameters when compared with standard drug methotrexate, which might be due to the presence of flavonoids, glycosides, alkaloids in the ethanolic extract of Cordia myxa leaves. Conclusion: The present study supports the traditional use of Cordia myxa leaves as potential anti-arthritic agent which can be effective in Freund’s complete adjuvant (FCA)-induced arthritis in rats, however its mode of action is still need to be studied.


Cite this article:
Jasmeet Kaur Chahal, Jasmine Chaudhary, Samrat Chauhan, Akash Jain, Ashwani Dhingra, Bhawna Chopra. Protective effect of Cordia myxa leaves extract in FCA-induced arthritis in rats. Research Journal of Pharmacy and Technology 2023; 16(9):4025-1. doi: 10.52711/0974-360X.2023.00660

Cite(Electronic):
Jasmeet Kaur Chahal, Jasmine Chaudhary, Samrat Chauhan, Akash Jain, Ashwani Dhingra, Bhawna Chopra. Protective effect of Cordia myxa leaves extract in FCA-induced arthritis in rats. Research Journal of Pharmacy and Technology 2023; 16(9):4025-1. doi: 10.52711/0974-360X.2023.00660   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-9-4


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